The Registry of Toxic Effects of Chemical Substances
Phthalonitrile RTECS #: TI8575000
CAS #: 91-15-6
The Registry of Toxic Effects of Chemical Substances
Phthalonitrile |
| UPDATE: September 1999 | MW: 128.14 | MF: C8H4N2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | mouse
lowest published toxic dose: 21 gm/kg/65 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Liver: Tumors Blood: Leukemia
VOONAW 18(1),81,1972
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oral | rat
lowest published toxic dose: 7,425 mg/kg/66 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Liver: Tumors Blood: Leukemia
VOONAW 18(1),81,1972
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subcutaneous | mouse
lowest published toxic dose: 7 gm/kg/63 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Blood: Leukemia Tumorigenic: Tumors at site of application
VOONAW 18(1),81,1972
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subcutaneous | rat
lowest published toxic dose: 473 mg/kg/21 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Liver: Tumors Blood: Leukemia
VOONAW 18(1),81,1972
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skin | mouse
lowest published toxic dose: 813 mg/kg/46 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Blood: Leukemia Reproductive: Tumorigenic effects: Ovarian tumors
VOONAW 18(1),81,1972
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intraperitoneal | mouse
lethal dose (50 percent kill): 25 mg/kg
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N/R
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NTIS** AD277-689
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intraperitoneal | rat
lethal dose (50 percent kill): 62 mg/kg
|
N/R
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KJMDA6 11,63,1965
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oral | cat
lowest published lethal dose: 20 mg/kg
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Behavioral: Convulsions or effect on seizure threshold
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ZAARAM 19,225,1969
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oral | mouse
lethal dose (50 percent kill): 65 mg/kg
|
Behavioral: Convulsions or effect on seizure threshold
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INHEAO 4,11,1966
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oral | rat
lethal dose (50 percent kill): 30 mg/kg
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Behavioral: Tremor | Behavioral: Convulsions or effect on seizure threshold
NTIS** OTS0540933
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oral | rabbit
lowest published lethal dose: 25 mg/kg
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Behavioral: Convulsions or effect on seizure threshold
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ZAARAM 19,225,1969
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subcutaneous | mouse
lethal dose (50 percent kill): 46 mg/kg
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Behavioral: Convulsions or effect on seizure threshold
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INHEAO 4,11,1966
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skin | guinea pig
lethal dose (50 percent kill): >1 gm/kg
|
N/R
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NTIS** OTS0540933
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
|
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
INHEAO
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Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki,
213 Japan) V.1- 1963-
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KJMDA6
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Kobe Journal of the Medical Sciences. (Kobe Univ. School of Medicine, Kusunoki-cho, Chuo-ku,
Kobe 650, Japan) V.1- 1951-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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VOONAW
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Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-
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ZAARAM
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Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25,
1951-75.
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