The Registry of Toxic Effects of Chemical Substances

Phthalimide, N - ( (trichloromethyl) thio) -

RTECS #: TI5685000

CAS #: 133-07-3

UPDATE: May 2005 MW: 296.55 MF: C9H4Cl3NO2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Orthophaltan
  2. Cymoxanil
  3. Folpan
  4. Folpel
  5. Folpet
  6. Ftalan
  7. Fungitrol II
  8. 1H - Isoindole - 1,3 (2H) - dione, 2 - ( (trichloromethyl) thio) -
  9. Phaltan
  10. Phthaltan
  1. Trichlormethylthioimid kyseliny ftalove (Czech)
  2. N - (Trichlor - methylthio) - phthalamid (German)
  3. N - (Trichlormethylthio) phthalimide
  4. Thiophal
  5. N - (Trichloromethylmercpato) phthalimide
  6. 2 - ( (Trichloromethyl) thio) - 1H - isoindole - 1,3 (2H) - dione
  7. N - (Trichloromethylthio) phthalimide
  8. Troysan anti - mildew O
  9. Vinicoll


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		0.1%/48 hour CODEDG 17,212,1987


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 15 µg/L/15 minute MUREAV 53,263,1978
dominant lethal test oral
rat 		500 mg/kg/5 day FCTXAV 10,363,1972
DNA damage human HeLa cell 1,300 nmol/L EMMUEG 17,20,1991
DNA inhibition human lymphocyte 5 mg/L ARTODN 45,101,1980
DNA inhibition human HeLa cell 1,300 nmol/L EMMUEG 17,20,1991
DNA inhibition rat other cell types 8 mg/L ARTODN 45,101,1980
DNA repair Bacillus subtilis 10 µg/disc MUREAV 40,19,1976
DNA repair Escherichia coli 4 µg/well MUREAV 133,161,1984
unscheduled DNA synthesis human fibroblast 100 µmol/L NTIS** PB268-647
mutation in microorganisms Bacillus subtilis 50 µg/plate (+/-enzymatic activation step) JAFCAU 29,268,1981
mutation in microorganisms Escherichia coli 5 µg/plate (+/-enzymatic activation step) NTIS** PB268-647
mutation in microorganisms Salmonella typhimurium 16 nmol/plate (+enzymatic activation step) CRNGDP 2,283,1981
mutation in microorganisms Salmonella typhimurium 1 µg/plate (-enzymatic activation step) NTIS** PB268-647
gene conversion and mitotic recombination Saccharomyes cerevisiae 200 ppm MUREAV 10,533,1970
mutation in mammalian somatic cells hamster ovary 250 µg/L ENMUDM 3,233,1981
mutation in mammalian somatic cells hamster ovary 0.75 mg/L/10 hour (-enzymatic activation step) FEREAC 68,10377,2003
mutation in mammalian somatic cells hamster ovary 0.26 mg/L/10 hour (+enzymatic activation step) FEREAC 68,10377,2003
mutation in mammalian somatic cells hamster ovary 25 mg/L/20 hour (+enzymatic activation step) FEREAC 68,10377,2003
mutation in mammalian somatic cells mouse lymphocyte 270 µg/L NTIS** PB84-138973
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		2,000 ppm JPFCD2 15,867,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 491 mg/m3/4 hour (6-13 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** PB84-128099
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg (5 day male) Reproductive: Effects on embryo or fetus: Fetal death FCTXAV 10,363,1972
oral
hamster 		lowest published toxic dose: 500 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TXAPA9 16,24,1970
oral
hamster 		lowest published toxic dose: 900 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 16,24,1970
oral
hamster 		lowest published toxic dose: 600 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 16,24,1970
oral
rat 		lowest published toxic dose: 500 mg/kg (5 day male) Reproductive: Effects on embryo or fetus: Fetal death FCTXAV 10,363,1972
oral
rabbit 		lowest published toxic dose: 488 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 13,420,1968
subcutaneous
mouse 		lowest published toxic dose: 900 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** PB223-160
subcutaneous
mouse 		lowest published toxic dose: 900 mg/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 437 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		JJCREP 81,514,1990
subcutaneous
mouse 		lowest published toxic dose: 1,000 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): >6 gm/m3/2 hour N/R TXAPA9 45,320,1978
inhalation
rat 		lethal concentration (50 percent kill): >5 gm/m3/2 hour N/R TXAPA9 45,320,1978
inhalation
rat 		lethal concentration (50 percent kill): >0.48 gm/m3/4 hour N/R FEREAC 68,1182,2003
intraperitoneal
mouse 		lethal dose (50 percent kill): 80 mg/kg Behavioral: Convulsions or effect on seizure threshold ABMGAJ 7,502,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 68,400 µg/kg N/R JTEHD6 9,867,1982
oral
mouse 		lethal dose (50 percent kill): 1,546 mg/kg N/R GTPZAB 18(5),50,1974
oral
rat 		lethal dose (50 percent kill): 2,636 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia 		NTIS** OTS0533649-9
oral
rat 		lethal dose (50 percent kill): >5,000 mg/kg N/R FEREAC 68,1182,2003
oral
rabbit 		lethal dose (50 percent kill): 1,115 mg/kg N/R GTPZAB 18(5),50,1974
skin
mouse 		lowest published lethal dose: 5 gm/kg N/R JACTDZ 9,642,1991
skin
rat 		lethal dose (50 percent kill): >5,000 mg/kg N/R FEREAC 68,1182,2003
skin
rabbit 		lethal dose (50 percent kill): >22,600 mg/kg N/R PEMNDP 9,431,1991
unreported route
mouse 		lethal dose (50 percent kill): 750 mg/kg N/R ABMGAJ 1,450,1958
unreported route
rat 		lethal dose (50 percent kill): >10 gm/kg N/R RREVAH 36,240,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 397,082 mg/kg/113 week- continuous Gastrointestinal: Tumors HBPTO* 1,814,2001
oral
mouse 		lowest published toxic dose: 109.5 gm/kg/2 year- continuous Gastrointestinal: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously 		FEREAC 68,10377,2003
oral
rat 		lowest published toxic dose: 45,000 mg/kg/90 day- continuous Brain and Coverings: Changes in brain weight

Biochemical: Metabolism (intermediary): Other proteins 		FEREAC 68,1182,2003
oral
rat 		lowest published toxic dose: 25,550 mg/kg/2 year- continuous Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Other changes 		FEREAC 68,1182,2003
skin
rat 		lowest published toxic dose: 21 mg/kg/6 hour/30 day- continuous Skin: After topical application: Primary irritation FEREAC 68,1182,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 32,3,1975
TOXICOLOGY REVIEW
MUREAV 557,109,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,121,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0327;
Number of Industries 4;
Total Number of Facilities 608;
Number of Occupations 8;
Total Number of Employees Exposed 1,240
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0327;
Number of Industries 8;
Total Number of Facilities 628;
Number of Occupations 21;
Total Number of Employees Exposed 10,509;
Total Number of Female Employees Exposed 1,422


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; TRP reversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: TRP reversion
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fungicide
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a fungicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Hormone
   Primary Irritant

ALT CAS #: 52306-33-9
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