The Registry of Toxic Effects of Chemical Substances
Phthalic acid, diisobutyl ester |
UPDATE: August 2003 | MW: 278.38 | MF: C16H22O4 |
SYNONYMS: | |
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
DNA damage | human lymphocyte | 354 mmol/L | MUREAV 467,21,2000 |
DNA damage | human other cell types | 354 mmol/L | MUREAV 467,21,2000 |
DNA damage | human other cell types | 216 ĩmol/L/60 minute | EMMUEG 35,9,2000 |
DNA damage | human lymphocyte | 354 mmol/L/60 minute | TCMUD8 21,189,2001 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal rat | lowest published toxic dose: 1,250 mg/kg (5-15 day pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | JPMSAE 61,51,1972 |
intraperitoneal rat | lowest published toxic dose: 375 mg/kg (5-15 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | JPMSAE 61,51,1972 |
oral mouse | lowest published toxic dose: 16,800 mg/kg (7 day male) |
Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Other effects on male | TOLED5 5,413,1980 |
oral mouse | lowest published toxic dose: 32 gm/kg (6-13 day pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | TCMUD8 7,29,1987 |
oral rat | lowest published toxic dose: 8,400 mg/kg (7 day male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 53,35,1980 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal mouse | lethal dose (50 percent kill): 3,990 mg/kg | N/R | JSCCA5 28,667,1977 |
intraperitoneal rat | lethal dose (50 percent kill): 3,750 ĩL/kg | N/R | JPMSAE 61,51,1972 |
oral mouse | lethal dose (50 percent kill): 10 gm/kg |
Behavioral: Muscle weakness Behavioral: Coma Lung, Thorax, or Respiration: Respiratory stimulation | GTPZAB 29(12),39,1985 |
oral rat | lethal dose (50 percent kill): 15 gm/kg | N/R | EVHPAZ 3,131,1973 |
skin guinea pig | lethal dose (50 percent kill): 10 gm/kg | N/R | EVHPAZ 4,3,1973 |
unreported route mouse | lethal dose (50 percent kill): 10,500 mg/kg | N/R | GTPZAB 32(7),52,1988 |
unreported route rat | lethal dose (50 percent kill): 20,500 mg/kg | N/R | GTPZAB 32(7),52,1988 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
TOXICOLOGY REVIEW |
| EVHPAZ 3,73,1973 |
TOXICOLOGY REVIEW |
| RREVAH 54,1,1975 |
TOXICOLOGY REVIEW |
| EVHPAZ 4,3,1973 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - DENMARK | time-weighted average 3 mg/m3, JAN1999 | |
Occupational Exposure Limit - RUSSIA | short term exposure limit 1 mg/m3, JAN1993 | |
Occupational Exposure Limit - SWEDEN | NGV 3 mg/m3, KTV 5 mg/m3, JAN1999 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 5 mg/m3, SEP2000 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 82792; Number of Industries 5; Total Number of Facilities 118; Number of Occupations 9; Total Number of Employees Exposed 3,373 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 82792![]() Number of Industries 7; Total Number of Facilities 230; Number of Occupations 19; Total Number of Employees Exposed 9,522; Total Number of Female Employees Exposed 380 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as plasticizer | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
REFERENCES: | |
CODEN |
REFERENCE |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
EVHPAZ | EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
JPMSAE | Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- |
JSCCA5 | Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
RREVAH | Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- |
TCMUD8 | Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- |
TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |