The Registry of Toxic Effects of Chemical Substances

Phthalic acid

RTECS #: TH9625000

CAS #: 88-99-3

UPDATE: August 2004 MW: 166.14 MF: C8H6O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acide phtalique (French)
  2. o - Dicarboxybenzene
  3. Benzene - 1,2 - dicarboxylic acid
  4. o - Benzenedicarboxylic acid
  1. 1,2 - Benzenedicarboxylic acid
  2. Kyselina ftalova (Czech)
  3. O - Phthalic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test intraperitoneal
mouse 		200 mg/kg/5 day- continuous MUREAV 422,207,1998
sperm morphology intraperitoneal
mouse 		100 mg/kg MUREAV 422,207,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 29,810 mg/kg (7-16 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TOLED5 93,109,1997


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 550 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis 		PSEBAA 49,471,1942
intraperitoneal
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R FCTOD7 41,405,2003
oral
mouse 		lethal dose (50 percent kill): 2,530 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		ATDAEI 1,711,1992
oral
mouse 		lethal dose (50 percent kill): >5,000 mg/kg N/R FCTOD7 41,405,2003
rectal
mouse 		lethal dose (50 percent kill): 510 mg/kg N/R FCTOD7 41,405,2003
unreported route
rat 		lethal dose (50 percent kill): 1,100 mg/kg N/R GISAAA 32(8),12,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 102 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) GISAAA 32(8),12,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
BPCT** -,183,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 59185;
Number of Industries 4;
Total Number of Facilities 106;
Number of Occupations 8;
Total Number of Employees Exposed 2,321
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 59185;
Number of Industries 22;
Total Number of Facilities 1,480;
Number of Occupations 27;
Total Number of Employees Exposed 19,693;
Total Number of Female Employees Exposed 2,861


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of dyes and dyestuffs, in medicines and in perfumes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used in synthesis of dyes and dyestuffs, in medicines and in perfumes

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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