The Registry of Toxic Effects of Chemical Substances
Phosphoryl chloride |
UPDATE: November 2004 | MW: 153.32 | MF: Cl3OP |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | guinea pig
lethal concentration (50 percent kill): 53 ppm/4 hour
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Eye: Other eye effects | Behavioral: Irritability Lung, Thorax, or Respiration: Dyspnea
AIHAAP 25,470,1964
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inhalation | mammal (species unspecified)
lowest published toxic concentration: 0.48 mg/m3
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Lung, Thorax, or Respiration: Cough
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VCVN5* -,72,1993
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inhalation | mouse
lethal concentration (50 percent kill): 404 mg/m3/2 hour
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N/R
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WDZAEK 6,98,1992
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inhalation | mouse
lowest published lethal concentration: 48 mg/m3/36 minute
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N/R
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VCVN5* -,72,1993
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inhalation | mouse
lowest published lethal concentration: 5.7 mg/m3/4 hour
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N/R
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VCVN5* -,72,1993
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inhalation | rat
lethal concentration (50 percent kill): 32 ppm/4 hour
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N/R
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28ZPAK -,17,1972
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inhalation | rat
lowest published lethal concentration: 48 mg/m3/36 minute
|
N/R
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VCVN5* -,72,1993
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inhalation | rat
lowest published lethal concentration: 5.7 mg/m3/4 hour
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N/R
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VCVN5* -,72,1993
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oral | mouse
lethal dose (50 percent kill): 327 mg/kg
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N/R
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WDZAEK 6,98,1992
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oral | rat
lethal dose (50 percent kill): 36 mg/kg
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Gastrointestinal: Other changes | Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0534840
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oral | rat
lethal dose (50 percent kill): 380 mg/kg
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N/R
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VCVN5* -,72,1993
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skin | rabbit
lowest published lethal dose: 1 gm/kg
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Behavioral: Muscle weakness | Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0534840
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | mammal (species unspecified)
lowest published toxic concentration: 1,340 µg/m3/17 week- intermittent
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Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Musculoskeletal: Osteoporosis Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)
JHEMA2 21,387,1977
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inhalation | rat
lowest published toxic concentration: 4 mg/m3/50 day- intermittent
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Lung, Thorax, or Respiration: Other changes
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WDZAEK 6,98,1992
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oral | mouse
lowest published toxic dose: 480 mg/kg/60 day- intermittent
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Liver: Other changes | Kidney, Ureter, and Bladder: Other changes Blood: Other changes
WDZAEK 6,98,1992
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oral | rat
lowest published toxic dose: 480 mg/kg/60 day- intermittent
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Liver: Other changes | Kidney, Ureter, and Bladder: Other changes Blood: Other changes
WDZAEK 6,98,1992
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 0.1 ppm
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DTLVS* TLV/BEI,2003
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Occupational Exposure Limit - AUSTRALIA
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time-weighted average 0.1 ppm (0.6 mg/m3), short term exposure limit 0.5 ppm, JAN1993
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Occupational Exposure Limit - AUSTRIA
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MAK 0.2 ppm (1 mg/m3), JAN1999
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Occupational Exposure Limit - BELGIUM
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time-weighted average 0.1 ppm (0.63 mg/m3), short term exposure limit 0.5 ppm, JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 0.1 ppm (0.6 mg/m3), JAN1999
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Occupational Exposure Limit - FINLAND
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short term exposure limit 0.5 ppm (3 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - FRANCE
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VME 0.1 ppm (0.6 mg/m3), JAN1999
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Occupational Exposure Limit - GERMANY
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MAK 0.2 ppm (1 mg/m3), JAN1999
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 0.6 mg/m3, 2003
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Occupational Exposure Limit - RUSSIA
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short term exposure limit 0.05 mg/m3, Skin, JAN1993
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 0.1 ppm (0.6 mg/m3), KZG- week 0.2 ppm (1.2 mg/m3), JAN1999
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Occupational Exposure Limit - TURKEY
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time-weighted average 0.5 ppm (3 mg/m3), JAN1993
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 0.2 ppm (1.3 mg/m3), short term exposure limit 0.6 ppm, SEP2000
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | time-weighted average 0.1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
time-weighted average 0.1 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS OXYCHLORIDE-air
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10 hour time-weighted average 0.1 ppm; | short term exposure limit 0.5 ppm
NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 81931; | Number of Industries 7; Total Number of Facilities 155; Number of Occupations 22; Total Number of Employees Exposed 7,258
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 81931; |
Number of Industries 9; Total Number of Facilities 165; Number of Occupations 29; Total Number of Employees Exposed 12,587; Total Number of Female Employees Exposed 2,945 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used in the manufacture of plasticizers, hydraulic fluids and gasoline additives
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
28ZPAK
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"Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro
Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
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AIHAAP
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American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH
44311) V.19- 1958-
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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JHEMA2
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Journal of Hygiene, Epidemiology, Microbiology, and Immunology. (Avicenum, Malostranske
namesti 28, 11802 Prague 1, Czechoslovakia) V.1- 1957-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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VCVN5*
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"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous
substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al.,
Chimia, 1989.
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WDZAEK
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Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu,
Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
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