The Registry of Toxic Effects of Chemical Substances

Phosphorous acid, triphenyl ester

RTECS #: TH1575000

CAS #: 101-02-0

UPDATE: August 2004 MW: 310.30 MF: C18H15O3P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. ADK Stab TPP
  2. Advance TPP
  3. JP 360
  4. Mellite 310
  5. Phenyl phosphite ( (C6H5O) 3P) (6CI,7CI)
  6. Phosclere T 36
  7. TP 1 (plasticizer)
  8. TPP (plasticizer)
  1. Sumilizer TPP - R
  2. Sumilizer TTP - R
  3. Trifenoxyfosfin (Czech)
  4. Trifenylfosfit (Czech)
  5. Triphenoxyphosphine
  6. Triphenyl phosphite
  7. Tris (phenoxy) phosphine
  8. Weston TPP


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,1117,1986
skin
human 		125 mg/48 hour severe AMIHBC 5,311,1952
skin
rabbit 		500 mg severe AMIHBC 5,311,1952
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,1117,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >6,700 mg/m3/1 hour N/R NTIS** OTS0532280
intraperitoneal
cat 		lowest published lethal dose: 100 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		NTIS** OTS0570901
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 250 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes 		AMIHBC 5,311,1952
intraperitoneal
mouse 		lethal dose (50 percent kill): 266 mg/kg N/R ABCHA6 31,1288,1967
intraperitoneal
rat 		lethal dose (50 percent kill): 250 mg/kg N/R 85JCAE -,1117,1986
intravenous
chicken 		lowest published lethal dose: 50 mg/kg Autonomic Nervous System: Ganglion blocker NEZAAQ 44,118,1989
oral
chicken 		lowest published lethal dose: 250 mg/kg Behavioral: Ataxia NTIS** OTS0532280
oral
mouse 		lethal dose (50 percent kill): 1,080 mg/kg N/R GTPZAB 31(12),53,1987
oral
rat 		lethal dose (50 percent kill): 444 mg/kg N/R GISAAA 46(12),13,1981
subcutaneous
cat 		lowest published lethal dose: 300 mg/kg Behavioral: Ataxia JPETAB 49,78,1933
subcutaneous
chicken 		lowest published lethal dose: 375 mg/kg Behavioral: Food intake (animal)

Behavioral: Ataxia 		NTIS** OTS0532280
subcutaneous
mammal (species unspecified) 		lowest published toxic dose: 1,184 mg/kg Spinal Cord: Other degenerative changes

Eye: Optic nerve neuropathy

Eye: Other eye effects 		NRTXDN 23,33,2002
subcutaneous
mammal (species unspecified) 		lowest published toxic dose: 1,184 mg/kg Brain and Coverings: Other degenerative changes

Eye: Optic nerve neuropathy

Eye: Retinal changes pigmentary deposition, retinitis, other) 		NRTXDN 23,33,2002
subcutaneous
rat 		lowest published lethal dose: 2 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Muscle weakness 		JPETAB 49,78,1933
skin
rabbit 		lowest published lethal dose: 5 gm/kg Behavioral: Somnolence (general depressed activity) NTIS** OTS0532280
unreported route
mouse 		lethal dose (50 percent kill): 1,360 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Change in motor activity (specific assay) 		GTPZAB 21(9),55,1977
unreported route
rat 		lethal dose (50 percent kill): 1,490 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Change in motor activity (specific assay) 		GTPZAB 21(9),55,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 9 mg/m3/4 hour/45 day- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 21(9),55,1977
subcutaneous
rat 		lowest published toxic dose: 3,552 mg/kg/7 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia 		FAATDF 29,110,1996
skin
chicken 		lowest published toxic dose: 5 gm/kg/5 day- intermittent Behavioral: Ataxia

Skin: After systemic exposure: Dermatitis, other

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NTIS** OTS0532280


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82978;
Number of Industries 15;
Total Number of Facilities 394;
Number of Occupations 34;
Total Number of Employees Exposed 10,448
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82978;
Number of Industries 45;
Total Number of Facilities 6,115;
Number of Occupations 46;
Total Number of Employees Exposed 84,276;
Total Number of Female Employees Exposed 6,323


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0393-8740
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Primary Irritant

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