The Registry of Toxic Effects of Chemical Substances

Phosphorous acid, trimethyl ester

RTECS #: TH1400000

CAS #: 121-45-9

UPDATE: November 2004 MW: 124.09 MF: C3H9O3P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Fosforyn trojmetylowy (Czech)
  2. Trimethoxyfosfin (Czech)
  3. Trimethoxyphosphine
  1. Trimethyl phosphite
  2. Trimethyl phosphite (ACGIH)
  3. Trimethylfosfit (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
mammal (species unspecified) 		100 mg mild MEPAAX 29,393,1978
skin
mammal (species unspecified) 		500 mg mild MEPAAX 29,393,1978
skin
rabbit 		500 mg severe 34ZIAG -,609,1969


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,640 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXAPA9 72,119,1984
oral
rat 		lowest published toxic dose: 1,640 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Homeostasis 		TXAPA9 72,119,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration : >32,700 mg/m3/6 hour Eye: Lacrimation

Eye: Ptosis

Behavioral: Somnolence (general depressed activity) 		NTIS** OTS0537047
inhalation
mouse 		lowest published lethal concentration: 32,700 mg/m3/6 hour Eye: Lacrimation

Eye: Ptosis

Behavioral: Somnolence (general depressed activity) 		NTIS** OTS0537047
inhalation
rat 		lowest published lethal concentration: 32,700 mg/m3/6 hour Eye: Lacrimation

Eye: Ptosis

Behavioral: Somnolence (general depressed activity) 		NTIS** OTS0537047
intraperitoneal
mouse 		lethal dose (50 percent kill): 4,180 mg/kg N/R ENVRAL 9,1,1975
oral
mouse 		lethal dose (50 percent kill): 4,280 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		NTIS** OTS0540442
oral
rat 		lethal dose (50 percent kill): 1,600 mg/kg N/R ALBRW* #OPB-3,1984
skin
rabbit 		lethal dose (50 percent kill): 2,600 mg/kg N/R AIHAAP 34,286,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 500 ppm/7.5 hour/8 week- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Skin and Appendages: Other: Hair 		AIHAAP 34,286,1973
oral
rat 		lowest published toxic dose: 689 mg/kg Olfaction: Other olfaction effects

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Other changes 		NTIS** OTS0540442


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.6 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 ppm (2.6 mg/m3), short term exposure limit 10 ppm (52 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg(Cd)/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (10 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYL PHOSPHITE-air 10 hour time-weighted average 2 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84215;
Number of Industries 5;
Total Number of Facilities 260;
Number of Occupations 7;
Total Number of Employees Exposed 1,891
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84215;
Number of Industries 2;
Total Number of Facilities 55;
Number of Occupations 18;
Total Number of Employees Exposed 14,190;
Total Number of Female Employees Exposed 6,312


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as intermediate in pesticide manufacture and as fireproofing agent in textile production
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8977;8EHQ-0892-8988
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9122
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as intermediate in pesticide manufacture and as fireproofing agent in textile production

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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