The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - dimethyl O - (2,4,5 - trichlorophenyl) ester

RTECS #: TG0525000

CAS #: 299-84-3

UPDATE: November 2004 MW: 321.54 MF: C8H8Cl3O3PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Blitex
  2. Dermafosu (Polish)
  3. Dermaphos
  4. Dimethyl trichlorophenyl thiophosphate
  5. Dow ET 14
  6. Dow ET 57
  7. ENT 23,284
  8. ET 14
  9. Ectoral
  10. Etrolene
  11. Fenchloorfos (Dutch)
  12. Fenchlorfos
  13. Fenchlorfosu (Polish)
  14. Fenchlorphos
  15. Korlan
  16. Korlane
  17. Moorman's Medicated Rid - Ezy
  18. Nanchor
  19. Nankor
  1. O,O - Dimethyl O - (2,4,5 - trichlorophenyl) thiophosphate
  2. O,O - Dimethyl O - 2,4,5 - trichlorophenyl phosphorothioate
  3. O,O - Dimethyl - O - (2,4,5 - trichlorphenyl) - thionophosphat (German)
  4. O - (2,4,5 - Trichloor - fenyl) - O,O - dimethyl - monothiofosfaat (Dutch)
  5. O - (2,4,5 - Trichlor - phenyl) - O,O - dimethyl - monothiophosphat (German)
  6. O - (2,4,5 - Tricloro - fenil) - O,O - dimetil - monotiofosfato (Italian)
  7. OMS 123
  8. Phenchlorfos
  9. Phenol, 2,4,5 - trichloro - , O - ester with O,O - dimethyl phosphorothioate
  10. Remelt
  11. Ronnel
  12. Ronnel (ACGIH:OSHA)
  13. Rovan
  14. Thiophosphate de O,O - dimethyle et de O - (2,4,5 - trichlorophenyle) (French)
  15. Trichlorometafos
  16. Trolen
  17. Trolene
  18. Viozene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange human lymphocyte 2 mg/L MUREAV 102,89,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lowest published toxic dose: 2,100 mg/kg (30-50 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		AVSCA7 24,99,1983
oral
mammal (species unspecified) 		lowest published toxic dose: 2,100 mg/kg (30-50 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Sex ratio 		AVSCA7 24,99,1983
oral
rat 		lowest published toxic dose: 368 mg/kg (16-22 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic NUPOBT 17,577,1979
oral
rat 		lowest published toxic dose: 6 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JTEHD6 10,111,1982
oral
rabbit 		lowest published toxic dose: 650 mg/kg (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system AVSCA7 24,295,1983
oral
rabbit 		lowest published toxic dose: 162 mg/kg (6-18 day pregnant) Reproductive: Other developmental abnormalities AVSCA7 24,295,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 118 mg/kg N/R PSEBAA 129,699,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 2,823 mg/kg N/R PSEBAA 129,699,1968
oral
wild bird 		lethal dose (50 percent kill): 80 mg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 6,375 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		BCTKAG 10,339,1977
oral
duck 		lethal dose (50 percent kill): 3,500 mg/kg N/R PCOC** -,965,1966
oral
dog 		lethal dose (50 percent kill): 500 mg/kg N/R 85GYAV -,26,1971
oral
domestic animal 		lowest published lethal dose: 1 gm/kg N/R VETNAL 51(8),101,1974
oral
guinea pig 		lethal dose (50 percent kill): 1,400 mg/kg N/R PCOC** -,965,1966
oral
mouse 		lethal dose (50 percent kill): 2 gm/kg N/R PCOC** -,965,1966
oral
rat 		lethal dose (50 percent kill): 625 mg/kg N/R GISAAA 45(6),14,1980
oral
rabbit 		lethal dose (50 percent kill): 420 mg/kg N/R PCOC** -,965,1966
oral
turkey 		lethal dose (50 percent kill): 500 mg/kg N/R JAFCAU 7,689,1959
subcutaneous
chicken 		lethal dose (50 percent kill): >1,600 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) BCPCA6 12,1377,1963
subcutaneous
rat 		lethal dose (50 percent kill): 1,380 mg/kg N/R GISAAA 52(11),24,1987
skin
guinea pig 		lethal dose (50 percent kill): 2 gm/kg N/R 85DPAN -,-,1971/1976
skin
rat 		lethal dose (50 percent kill): 2 gm/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 1 gm/kg N/R FMCHA2 -,C265,1991
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 400 mg/kg N/R 30ZDA9 -,333,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 5,940 mg/kg/2 year- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 23,1,1972
oral
rat 		lowest published toxic dose: 350 mg/kg/14 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		BCTKAG 10,351,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,206,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 DTLVS* 3,222,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 15 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO RONNEL-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 67525;
Number of Industries 2;
Total Number of Facilities 86;
Number of Occupations 2;
Total Number of Employees Exposed 383
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 67525;
Number of Industries 2;
Total Number of Facilities 333;
Number of Occupations 2;
Total Number of Employees Exposed 3,824;
Total Number of Female Employees Exposed 574


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
AVSCA7 Acta Veterinaria Scandinavica. (Danske Dyrlargeforening, Alhambravej 15, DK-1826 Copenhagen V, Denmark) V.1- 1959-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NUPOBT Neuropatologia Polska. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1963-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as an insecticide for livestocks

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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