The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - dimethyl O - (4 - nitro - m - tolyl) ester

RTECS #: TG0350000

CAS #: 122-14-5

UPDATE: November 2004 MW: 277.25 MF: C9H12NO5PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Agria 1050
  2. Agriya 1050
  3. Agrothion
  4. American cyanamid CL - 47,300
  5. Arbogal
  6. BAY 41831
  7. Bayer 41831
  8. Bayer S 5660
  9. CL 47300
  10. CP 47114
  11. m - Cresol, 4 - nitro - , O - ester with O,O - dimethyl phosphorothioate
  12. O,O - Dimethyl - O - (3 - methyl - 4 - nitrofenyl) - monothiofosfaat (Dutch)
  13. O,O - Dimethyl - O - (3 - methyl - 4 - nitro - phenyl) - monothiophosphat (German)
  14. O,O - Dimethyl O - (3 - methyl - 4 - nitrophenyl) phosphorothioate
  15. Dimethyl 3 - methyl - 4 - nitrophenyl phosphorothionate
  16. O,O - Dimethyl O - (3 - methyl - 4 - nitrophenyl) phosphorothionate
  17. O,O - Dimethyl O - (3 - methyl - 4 - nitrophenyl) thiophosphate
  18. O,O - Dimethyl - O - (4 - nitro - 5 - methylphenyl) - thionophosphat (German)
  19. O,O - Dimethyl O - (4 - nitro - 3 - methylphenyl) thiophosphate
  20. O,O - Dimethyl O - 4 - nitro - m - tolyl phosphorothioate
  21. Dimethyl 4 - nitro - m - tolyl phosphorothionate
  22. O,O - Dimetil - O - (3 - metil - 4 - nitrofenil) fosforotioato (Portugese)
  23. O,O - Dimetil - O - (3 - metil - 4 - nitro - fenil) - monotiofosfato (Italian)
  24. Fenitrothion
  25. Fenitrotion (Hungarian)
  26. Fenition
  27. Nuvanol
  28. Novathion
  29. Oleosumifene
  30. OMS 43
  31. Ovadofos
  32. Owadofos
  33. Phenitrothion
  34. AC - 47300
  1. Accothion
  2. Cekutrothion
  3. EI 47300
  4. ENT 25,715
  5. Folithion
  6. Folithion EC 50
  7. 8057HC
  8. Insectigas F
  9. Kotion
  10. Macbar
  11. MEP (pesticide)
  12. Metathion
  13. Metathione
  14. Metathion E 50
  15. Metathionine
  16. Metathionine E50
  17. Metation
  18. Metation E50
  19. 3 - Methyl - 4 - nitrophenyl dimethyl phosphorothioate
  20. Methylnitrophos
  21. Mglawik F
  22. Monsanto CP 47114
  23. Pennwalt C - 4852
  24. S 5660
  25. S 112A
  26. Phosphorothioic acid, O,O - dimethyl O - (3 - methyl - 4 - nitrophenyl) ester
  27. Sumifene
  28. Sumithion
  29. Sumitomo S - 1102A
  30. Super Sumithion
  31. Thiophosphate de O,O - dimethyle et de O - (3 - methyl - 4 - nitrophenyle) (French)
  32. Tionofosforan O,O - dwumetylo - O - (3 - metylo) - 4 - nitrofenylowy (Polish)
  33. Verthion


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 200 mg/L GMCRDC 27,95,1981
cytogenetic analysis human leukocyte 40 mg/L HOEKAN 29,33,1979
cytogenetic analysis human lymphocyte 40 mg/L CHYCDW 20,354,1986
DNA inhibition other microorganisms 100 ppm NNGADV 9,325,1984
mutation in microorganisms Salmonella typhimurium 500 µg/plate (+enzymatic activation step) MUREAV 116,185,1983
mutation in microorganisms Salmonella typhimurium 400 µg/plate (-enzymatic activation step) CHYCDW 20,354,1986
other mutation test systems other microorganisms 100 ppm NNGADV 9,325,1984
sister chromatid exchange hamster lung 277 mg/L SNSHBT (20),574,1980
sister chromatid exchange human embryo 55,400 µg/L SNSHBT (20),574,1980
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		5 ppm MUREAV 260,225,1991
specific locus test oral
Drosophila melanogaster 		100 ppb MUREAV 260,225,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 90 mg/kg (7-15 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Other postnatal measures or effects 		NETEEC 11,321,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lethal dose (50 percent kill): 1 gm/kg N/R PCBPBS 8,302,1978
inhalation
rat 		lethal concentration (50 percent kill): 378 mg/m3/4 hour Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		EGESAQ 24,173,1980
intraperitoneal
mouse 		lethal dose (50 percent kill): 280 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase ABCHA6 25,605,1961
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Brain and Coverings: Other degenerative changes TOLED5 135,89,2002
intraperitoneal
rat 		lethal dose (50 percent kill): 300 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Lung, Thorax, or Respiration: Fibrosis (interstitial) 		TXAPA9 63,91,1982
intratracheal
rat 		lethal dose (50 percent kill): 950 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Tremor

Lung, Thorax, or Respiration: Fibrosis (interstitial) 		TXAPA9 63,91,1982
intravenous
guinea pig 		lethal dose (50 percent kill): 112 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase

Lung, Thorax, or Respiration: Dyspnea

Behavioral: Convulsions or effect on seizure threshold 		ABCHA6 27,669,1963
intravenous
mouse 		lethal dose (50 percent kill): 220 mg/kg N/R RREVAH 68,1,1977
intravenous
rat 		lethal dose (50 percent kill): 33 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase

Lung, Thorax, or Respiration: Dyspnea

Behavioral: Convulsions or effect on seizure threshold 		ABCHA6 27,669,1963
oral
wild bird 		lethal dose (50 percent kill): 11 mg/kg N/R AECTCV 12,355,1983
oral
cat 		lethal dose (50 percent kill): 142 mg/kg N/R ABCHA6 25,605,1961
oral
chicken 		lethal dose (50 percent kill): 280 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 11,49,1967
oral
chicken 		lethal dose (50 percent kill): 500 mg/kg N/R HBPTO* 2,957,2001
oral
duck 		lethal dose (50 percent kill): 1,190 mg/kg N/R TXAPA9 47,451,1979
oral
guinea pig 		lethal dose (50 percent kill): 500 mg/kg N/R 85DPAN -,-,1971/1976
oral
mammal (species unspecified) 		lethal dose (50 percent kill): >727 mg/kg N/R RREVAH 68,1,1977
oral
man 		lowest published lethal dose: 429 µL/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes 		HUTODJ 6,403,1987
oral
mouse 		lethal dose (50 percent kill): 229 mg/kg N/R TOIZAG 25,635,1978
oral
quail 		lethal dose (50 percent kill): 56,200 µg/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 250 mg/kg N/R JEENAI 61,743,1968
oral
woman 		lowest published toxic dose: 800 mg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Lung, Thorax, or Respiration: Dyspnea 		ARTODN 56,136,1984
subcutaneous
mouse 		lethal dose (50 percent kill): 1 gm/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase ABCHA6 25,605,1961
subcutaneous
rat 		lethal dose (50 percent kill): 1,300 mg/kg N/R NNGADV 13,401,1988
skin
duck 		lethal dose (50 percent kill): 504 mg/kg N/R TXAPA9 47,451,1979
skin
mouse 		lethal dose (50 percent kill): 2,500 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase ABCHA6 25,605,1961
skin
rat 		lethal dose (50 percent kill): 1,002 mg/kg N/R AIBOA3 37,219,1970
skin
rabbit 		lethal dose (50 percent kill): 1,250 mg/kg N/R GISAAA 31(10),12,1966
unreported route
cattle 		lethal dose (50 percent kill): 217 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Change in motor activity (specific assay) 		IJLAA4 49,314,1979
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 142 mg/kg N/R 30ZDA9 -,330,1971
unreported route
mouse 		lethal dose (50 percent kill): 470 mg/kg N/R GTPZAB 7(5),38,1963
unreported route
rat 		lethal dose (50 percent kill): 290 mg/kg N/R NYKZAU 74,41P,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 3,800 µg/m3/4 hour/9 week- intermittent Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 31(10),12,1966
inhalation
rat 		lowest published toxic concentration: 12 mg/m3/2 hour/13 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JOUOD4 10,71,1988
inhalation
rat 		lowest published toxic concentration: 17 mg/m3/17 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 31(10),12,1966
inhalation
rat 		lowest published toxic concentration: 15 mg/m3/2 hour/4 week- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NNGADV 13,401,1988
inhalation
rat 		lowest published toxic concentration: 57 mg/m3/2 hour/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 62,32,1982
oral
domestic bird 		lowest published toxic dose: 22,500 µg/kg/5 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AECTCV 11,617,1982
oral
chicken 		lowest published toxic dose: 1,960 mg/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 11,49,1967
oral
mouse 		lowest published toxic dose: 140 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		FAATDF 33,246,1996
oral
quail 		lowest published toxic dose: 179 mg/kg/4 week- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		BOCKAF 40,54,1975
oral
rat 		lowest published toxic dose: 400 mg/kg/40 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTOTDY 3,313,1981
oral
rat 		lowest published toxic dose: 760 mg/kg/12 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		BCTKAG 11,151,1978
oral
rat 		lowest published toxic dose: 406 mg/kg/28 day- continuous Endocrine: Hyperglycemia

Endocrine: Changes in adrenal weight

Blood: Other changes 		TOLED5 11,187,1982
oral
rat 		lowest published toxic dose: 456 mg/kg/1 year- continuous Cardiac: Changes in heart weight

Related to Chronic Data: Changes in uterine weight 		JTSCDR 7,43,1982
oral
rat 		lowest published toxic dose: 15 mg/kg/5 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JTSCDR 25,403,2000
oral
rat 		lowest published toxic dose: 15 mg/kg/5 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JTSCDR 25,403,2000
oral
rabbit 		lowest published toxic dose: 560 mg/kg/8 week- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath APTOA6 39,374,1976
skin
rabbit 		lowest published toxic dose: 10,500 mg/kg/21 day- intermittent Behavioral: Sleep

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NNGADV 13,401,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
MZUZA8 (8),90,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,119,1998
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.02 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used to control chewing and sucking insects on rice, orchard fruits, vegetables, etc.
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AIBOA3 Arquivos do Instituto Biologico, Sao Paulo. (Instituto Biologico, Caixa Postal 7119, 01000 Sao Paulo, Brazil) V.34- 1967-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BOCKAF Bochu Kagaku. Scientific Pest Control. (Kyoto, Japan) V.1-42, 1937-77. Discontinued.
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EGESAQ Egeszsegtudomany. (Kultura, POB 149, H-1389 Budapest, Hungary) V.1- 1957-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
IJLAA4 Indian Journal of Animal Sciences. (Indian Council of Agricultural Research, Krishi Bhavan, New Delhi 110 001, India) V.39- 1969-
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
JOUOD4 Journal of UOEH (University of Occupational and Environmental Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering in 1976.
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used to control chewing and sucking insects on rice, orchard fruits, vegetables, etc.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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