The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - dimethyl O - (p - nitrophenyl) ester

RTECS #: TG0175000

CAS #: 298-00-0

UPDATE: May 2005 MW: 263.22 MF: C8H10NO5PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 8056HC
  2. Azofos
  3. Azophos
  4. BAY 11405
  5. BAY E - 601
  6. Bladan - M
  7. Cekumethion
  8. Dalf
  9. Demethylfenitrothion
  10. Devithion
  11. Dimethyl 4 - nitrophenyl phosphorothionate
  12. Dimethyl p - nitrophenyl monothiophosphate
  13. Dimethyl p - nitrophenyl thiophosphate
  14. Dimethyl parathion
  15. Dimethyl - p - nitrophenyl thionphosphate
  16. Drexel methyl parathion 4E
  17. ENT 17,292
  18. Folidol M
  19. Folidol - 80
  20. Fosferno M 50
  21. Kilex parathion
  22. M - Parathion
  23. Mepaton
  24. Meptox
  25. Metacid
  26. Metacid 50
  27. Metafos
  28. Metaphos
  29. Methyl fosferno
  30. Methyl niran
  31. Methyl parathion
  32. Methyl parathion (ACGIH)
  33. Methyl - E 605
  34. Metilparation (Hungarian)
  35. Metron (pesticide)
  36. Metyloparation (Polish)
  1. Metylparation (Czech)
  2. NCI - C02971
  3. Nitrox
  4. Nitrox 80
  5. O,O - Dimethyl O - (p - nitrophenyl) phosphorothioate
  6. O,O - Dimethyl O - (p - nitrophenyl) thionophosphate
  7. O,O - Dimethyl O - 4 - nitrophenyl phosphorothioate
  8. O,O - Dimethyl O - p - nitrophenyl thiophosphate
  9. O,O - Dimethyl - O - (4 - nitro - fenyl) - monothiofosfaat (Dutch)
  10. O,O - Dimethyl - O - (4 - nitro - phenyl) - monothiophosphat (German)
  11. O,O - Dimethyl - O - (4 - nitrophenyl) phosphorothioate
  12. O,O - Dimethyl - O - (4 - nitrophenyl) - thionophosphat (German)
  13. O,O - Dimethyl - O - (p - nitrophenyl) - thionophosphat (German)
  14. O,O - Dimethyl - O - p - nitrofenylester kyseliny thiofosforecne (Czech)
  15. O,O - Dimethyl - O - p - nitrofenylthiofosfat (Czech)
  16. O,O - Dimetil - O - (4 - nitro - fenil) - monotiofosfato (Italian)
  17. Oleovofotox
  18. Parapest M - 50
  19. Parataf
  20. Parathion methyl
  21. Parathion - metile (Italian)
  22. Penncap - M
  23. Phenol, p - nitro - , O - ester with O,O - dimethylphosphorothioate
  24. Phosphorothioic acid, O,O - dimethyl O - (4 - nitrophenyl) ester
  25. Quinophos
  26. RCRA waste number P071
  27. Sinafid M - 48
  28. Tekwaisa
  29. Thiophenit
  30. Thiophosphate de O,O - dimethyle et de O - (4 - nitrophenyle) (French)
  31. Thylpar M - 50
  32. Vofatox
  33. Wofatox
  34. Yphos
  35. p - Nitrophenyldimethylthionophosphate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
mouse 		10 mg/kg SOGEBZ 11,1534,1975
cytogenetic analysis intraperitoneal
rat 		3 mg/kg MUREAV 321,103,1994
dominant lethal test oral
Drosophila melanogaster 		4,500 ng/L FCTOD7 33,309,1995
DNA damage Escherichia coli 100 mg/L MUREAV 52,161,1978
DNA repair other microorganisms 50 µL/plate BIZNAT 95,463,1976
DNA repair Salmonella typhimurium 250 µg/disc JPFCD2 19,565,1984
mutation in microorganisms Escherichia coli 10 mmol/L (-enzymatic activation step) MUREAV 20,7,1973
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) CYGEDX 15(3),64,1981
mutation in microorganisms Salmonella typhimurium 667 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 0.5 mmol/L/3 day (+enzymatic activation step) MUREAV 536,103,2003
micronucleus test intraperitoneal
mouse 		1 mg/kg MUREAV 155,131,1985
micronucleus test oral
mouse 		9,375 µg/kg MUTAEX 5,147,1990
micronucleus test intraperitoneal
rat 		2,500 µg/kg/5 day- continuous MUREAV 188,45,1987
gene conversion and mitotic recombination Saccharomyes cerevisiae 114 mmol/L IARCCD 10,161,1974
mutation in mammalian somatic cells mouse lymphocyte 100 mg/L NTIS** PB84-138973
sister chromatid exchange hamster lung 10 mg/L MUREAV 88,307,1981
sister chromatid exchange human lymphocyte 20 mg/L MUREAV 88,307,1981
specific locus test multiple
Drosophila melanogaster 		31,500 ppb ARTODN 61,53,1987
specific locus test oral
Drosophila melanogaster 		6 µg/L FCTOD7 33,309,1995
sperm morphology oral
mouse 		9,375 µg/kg MUREAV 280,169,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 60 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		AEHLAU 15,609,1967
intraperitoneal
rat 		lowest published toxic dose: 15 mg/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) AEHLAU 15,609,1967
intraperitoneal
rat 		lowest published toxic dose: 45 mg/kg (15 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		IJEBA6 37,176,1999
oral
rat 		lowest published toxic dose: 9 mg/kg (7-15 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Behavioral 		JPFCD2 15,365,1980
oral
rat 		lowest published toxic dose: 15 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) 		JEBIDP 17,51,1996
oral
rat 		lowest published toxic dose: 600 µg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) AXVMAW 30,343,1976
oral
rat 		lowest published toxic dose: 2,200 µg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) GISAAA 38(8),21,1973
oral
rat 		lowest published toxic dose: 900 mg/kg (30 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) ETOPFR 14,91,2003
skin
rat 		lowest published toxic dose: 10 mg/kg (18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system 		JTEHD6 63,173,2001
unreported route
rat 		lowest published toxic dose: 44 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Behavioral AMSHAR 28,210,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lethal dose (50 percent kill): 47 mg/kg N/R PCBPBS 8,302,1978
inhalation
mouse 		lethal concentration (50 percent kill): 120 mg/m3/4 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
inhalation
rat 		lethal concentration (50 percent kill): 34 mg/m3/4 hour Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		EGESAQ 24,173,1980
intraperitoneal
mouse 		lethal dose (50 percent kill): 5,400 µg/kg N/R PCBPBS 8,302,1978
intraperitoneal
rat 		lethal dose (50 percent kill): 2,800 µg/kg N/R APCRAW 4,117,1961
intravenous
guinea pig 		lethal dose (50 percent kill): 50 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
intravenous
mouse 		lethal dose (50 percent kill): 9,800 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
intravenous
rat 		lethal dose (50 percent kill): 9 mg/kg N/R NTIS** PB277-077
oral
wild bird 		lethal dose (50 percent kill): 5 mg/kg N/R JTCEEM 6(3),175,1986
oral
duck 		lethal dose (50 percent kill): 10 mg/kg N/R DOEAAH 35,25,1979
oral
dog 		lethal dose (50 percent kill): 90 mg/kg Gastrointestinal: Nausea or vomiting PESTD5 16,273,1975
oral
guinea pig 		lethal dose (50 percent kill): 1,270 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 57 mg/kg Behavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		NTIS** PB288-416
oral
mouse 		lethal dose (50 percent kill): 17,800 µg/kg N/R HETOEA 11,11,1992
oral
rat 		lethal dose (50 percent kill): 6,010 µg/kg N/R 85JCAE -,1155,1986
oral
rat 		lowest published toxic dose: 1.75 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,309,2003
oral
rat 		lowest published toxic dose: 0.6 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		TOSCF2 76,400,2003
oral
rabbit 		lethal dose (50 percent kill): 420 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** PB241-840
subcutaneous
mouse 		lethal dose (50 percent kill): 18 mg/kg N/R BLLIAX 38,151,1958
subcutaneous
rat 		lethal dose (50 percent kill): 6 mg/kg N/R JEENAI 50,356,1957
subcutaneous
rabbit 		lowest published toxic dose: 37.05 mg/kg Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 191,33,2003
skin
duck 		lethal dose (50 percent kill): 54 mg/kg N/R TXAPA9 47,451,1979
skin
mouse 		lethal dose (50 percent kill): 1,200 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JTEHD6 9,491,1982
skin
rat 		lethal dose (50 percent kill): 67 mg/kg N/R WRPCA2 4,36,1965
skin
rat 		lowest published toxic dose: 10 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Changes in leukocyte (WBC) count

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		JTEHD6 63,173,2001
skin
rabbit 		lethal dose (50 percent kill): 300 mg/kg N/R AFDOAQ 16,3,1952
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 25 mg/kg N/R 30ZDA9 -,327,1971
unreported route
mouse 		lethal dose (50 percent kill): 23 mg/kg N/R BWHOA6 44,31,1971
unreported route
rat 		lethal dose (50 percent kill): 10 mg/kg N/R NYKZAU 74,41P,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 24 µg/m3/24 hour/93 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 33(10),10,1968
intraperitoneal
rat 		lowest published toxic dose: 7 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		IJTHEZ 1,95,1991
intraperitoneal
rat 		lowest published toxic dose: 7 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes 		HBPTO* 2,1027,2001
oral
domestic bird 		lowest published toxic dose: 20,500 µg/kg/5 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AECTCV 11,617,1982
oral
cat 		lowest published toxic dose: 91 mg/kg/26 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FATOAO 20(3),78,1957
oral
dog 		lowest published toxic dose: 42 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 1,1,1959
oral
human 		lowest published toxic dose: 2.4 mg/kg/24 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 1,59,2001
oral
mammal (species unspecified) 		lowest published toxic dose: 202 mg/kg/12 day- continuous Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AECTCV 16,357,1987
oral
mammal (species unspecified) 		lowest published toxic dose: 4,450 mg/kg/30 day- continuous Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** PB288-416
oral
rat 		lowest published toxic dose: 13,200 µg/kg/6 week- intermittent Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Decreased motility or constipation

Kidney, Ureter, and Bladder: Incontinence 		NETEEC 12,125,1990
oral
rat 		lowest published toxic dose: 182 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 23(12),19,1958
oral
rat 		lowest published toxic dose: 1,400 µg/kg/15 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXCYAC 75,13,1992
oral
rat 		lowest published toxic dose: 25 mg/kg/21 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Nutritional and Gross Metabolic: Body temperature decrease 		TXCYAC 75,13,1992
oral
rat 		lowest published toxic dose: 35 mg/kg/4 week- continuous Liver: Other changes

Liver: Other changes 		FATOAO 39,470,1976
oral
rat 		lowest published toxic dose: 4.2 mg/kg/21 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,127,2003
oral
rat 		lowest published toxic dose: 1.8 mg/kg/6 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOSCF2 76,400,2003
oral
rat 		lowest published toxic dose: 900 mg/kg/30 day- intermittent Blood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight 		ETOPFR 14,91,2003
oral
rabbit 		lowest published toxic dose: 48 mg/kg/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		BECTA6 54,258,1995
oral
rabbit 		lowest published toxic dose: 9.2 mg/kg/57 day- continuous Endocrine: Change in gonadotropins

Endocrine: Changes in spleen weight

Immunological Including Allergic: Decreased immune response 		TXAPA9 32,587,1975
oral
rabbit 		lowest published toxic dose: 29.6 mg/kg/57 day- continuous Endocrine: Other changes

Blood: Changes in spleen 		TXAPA9 32,587,1975
subcutaneous
rat 		lowest published toxic dose: 20 mg/kg/10 day- intermittent Behavioral: Alteration of operant conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NETEEC 24,797,2002
subcutaneous
rat 		lowest published toxic dose: 21 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,304,2003
subcutaneous
rat 		lowest published toxic dose: 20 mg/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NETEEC 24,797,2002
skin
rat 		lowest published toxic dose: 60 mg/kg/30 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		IJEBA6 29,149,1991
skin
rat 		lowest published toxic dose: 65 mg/kg/13 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 72,89,2003
skin
rat 		lowest published toxic dose: 9.5 mg/kg/95 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,304,2003
skin
rat 		lowest published toxic dose: 16 mg/kg/16 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,128,2003
skin
rat 		lowest published toxic dose: 32 mg/kg/16 day- intermittent Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,128,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal NO EVIDENCE IMSUDL 7,392,1987
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,131,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
ECMAAI 14,141,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
TOLED5 128,45,2002
TOXICOLOGY REVIEW
MUREAV 567,109,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,132,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 (skin) DTLVS* 3,168,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, short term exposure limit 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL PARATHION-air 10 hour time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109105/AS)
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
used as a broad spectrum insecticide in a wide variety of agricultural applications
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-157,1979


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74.
AMSHAR Acta Morphologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-30, 1951-82.
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
BLLIAX Bratislavske Lekarske Listy. (PNS-Ustredna Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava, Czechoslovakia) V.1- 1921-
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210)
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
ECMAAI Economie et Medecine Animales. (Paris, France) V.1-17, 1960-76. Discontinued.
EGESAQ Egeszsegtudomany. (Kultura, POB 149, H-1389 Budapest, Hungary) V.1- 1957-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
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used as a broad spectrum insecticide in a wide variety of agricultural applications

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 37359-35-6
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