The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - dimethyl ester, S - ester with 2 - ( (2 - mercaptoethyl) thio) - N - methylpropionamide

RTECS #: TF7900000

CAS #: 2275-23-2

UPDATE: January 1998 MW: 287.36 MF: C8H18NO4PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. American cyanamid - 43073
  2. O,O - Dimethyl S - 2 - (1 - N - methylcarbamoylethylmercapto) ethyl thiophosphate
  3. Dimethyl S - (2 - (1 - methylcarbamoylethylthio) ethyl) phosphorothiolate
  4. O,O - Dimethyl S - (2 - (1 - methylcarbamoylethylthio) ethyl) phosphorothioate
  5. NPH 83
  6. ENT 26,613
  7. Kilval
  1. N - Methyl O,O - dimethylthiolophosphoryl - 5 - thia - 3 - methyl - 2 - valeramide
  2. N - Methyl - 3 - thia - 2 - methyl - valeramid der O,O - dimethylthiolphosphorsaeure (German)
  3. RP - 9895
  4. R.P. 10,465
  5. Trucidor
  6. Vamidoate
  7. Vamidothion


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 5 mmol/L MUREAV 78,177,1980
DNA repair Bacillus subtilis 25 pph MUREAV 40,19,1976
mutation in microorganisms Escherichia coli 25 pph (-enzymatic activation step) MUREAV 40,19,1976
mutation in microorganisms Salmonella typhimurium 25 pph (+enzymatic activation step) MUREAV 40,19,1976
sister chromatid exchange hamster lung 1 mmol/L MUREAV 78,177,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,730 mg/m3/4 hour N/R PEMNDP 9,856,1991
oral
wild bird 		lethal dose (50 percent kill): 35 mg/kg N/R PEMNDP 9,856,1991
oral
dog 		lethal dose (50 percent kill): 110 mg/kg N/R GUCHAZ 6,530,1973
oral
guinea pig 		lethal dose (50 percent kill): 85 mg/kg N/R GUCHAZ 6,530,1973
oral
mouse 		lethal dose (50 percent kill): 40 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		MZUZA8 (8),65,1972
oral
rat 		lethal dose (50 percent kill): 64 mg/kg N/R 28ZEAL 5,233,1976
oral
rabbit 		lethal dose (50 percent kill): 160 mg/kg N/R GTPZAB 14(2),58,1970
skin
mouse 		lethal dose (50 percent kill): 1,460 mg/kg N/R YKYUA6 37,1621,1986
skin
rabbit 		lethal dose (50 percent kill): 1,160 mg/kg N/R WRPCA2 9,119,1970
unreported route
cat 		lethal dose (50 percent kill): 117 mg/kg Behavioral: Ataxia

Behavioral: Coma

Kidney, Ureter, and Bladder: Urine volume increased 		GISAAA 41(3),107,1976
unreported route
guinea pig 		lethal dose (50 percent kill): 85 mg/kg N/R 30ZDA9 -,349,1971
unreported route
mouse 		lethal dose (50 percent kill): 43 mg/kg N/R 30ZDA9 -,349,1971
unreported route
rat 		lethal dose (50 percent kill): 64 mg/kg N/R 30ZDA9 -,349,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,020 µg/m3/22 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 30(5),11,1965
oral
mouse 		lowest published toxic dose: 420 mg/kg/15 week- intermittent Brain and Coverings: Changes in circulation

Liver: Hepatitis (hepatocellular necrosis), diffuse

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		MZUZA8 (8),65,1972
oral
rat 		lowest published toxic dose: 678 mg/kg/17 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GTPZAB 14(2),58,1970
oral
rat 		lowest published toxic dose: 375 mg/kg/1 year- intermittent Endocrine: Changes in adrenal weight

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 41(3),107,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: TRP reversion


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an insecticide and acaricide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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