The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - diethyl O - (3,5,6 - trichloro - 2 - pyridyl) ester

RTECS #: TF6300000

CAS #: 2921-88-2

UPDATE: May 2005 MW: 350.59 MF: C9H11Cl3NO3PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Pyridinol, 3,5,6 - trichloro - , O - ester with O,O - diethyl phosphorothioate
  2. Analytical grade chlorpyrifos
  3. Brodan
  4. Chlorpyrifos
  5. Chlorpyrifos (ACGIH)
  6. Chlorpyrifos - ethyl
  7. Chlorpyriphos
  8. Chlorpyriphos - ethyl
  9. Detmol U.A.
  10. Dowco 179
  11. Dursban
  12. Dursban F
  13. ENT 27311
  1. Ethion, dry
  2. Lorsban
  3. Lorsban 4E
  4. Lorsban 50SL
  5. O,O - Diaethyl - O - 3,5,6 - trichlor - 2 - pyridylmonothiophosphat (German)
  6. O,O - Diethyl O - (3,5,6 - trichloro - 2 - pyridinyl) phosphorothioate
  7. O,O - Diethyl O - 3,5,6 - trichloro - 2 - pyridyl phosphorothioate
  8. OMS - 0971
  9. Piridane
  10. Pyrinex
  11. Stipend
  12. Zidil


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis mouse other cell types 500 µg/L MUREAV 279,165,1992
DNA damage oral
mouse 		0.28 mg/kg MUREAV 516,139,2002
sister chromatid exchange human lymphocyte 2 mg/L MUREAV 102,89,1982
sister chromatid exchange mouse other cell types 1 mg/L MUREAV 279,165,1992
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		50 ppb ENMUDM 5,835,1983
specific locus test oral
Drosophila melanogaster 		50 ppb MUREAV 279,15,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 80 mg/kg (1 day prior to copulation) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) REPTED 17,401,2003
intraperitoneal
rat 		lowest published toxic dose: 210 µg/kg (1-7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system VHTODE 34,498,1992
intraperitoneal
rat 		lowest published toxic dose: 4,500 µg/kg (7-21 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system VHTODE 34,498,1992
oral
mouse 		lowest published toxic dose: 250 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 54,31,1980
oral
rat 		lowest published toxic dose: 25 mg/kg (14-18 day pregnant) Reproductive: Other effects on female TOSCF2 52,92,1999
oral
rat 		lowest published toxic dose: 135 mg/kg (6-22 day pregnant/10 day after birth) Reproductive: Other effects on female

Reproductive: Effects on newborn: Biochemical and metabolic 		TOSCF2 53,438,2000
oral
rat 		lowest published toxic dose: 250 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		REPTED 17,203,2003
oral
rat 		lowest published toxic dose: 250 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Hepatobiliary system 		REPTED 17,203,2003
oral
rat 		lowest published toxic dose: 250 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear REPTED 17,203,2003
oral
rat 		lowest published toxic dose: 150 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system REPTED 17,203,2003
oral
rat 		lowest published toxic dose: 45 mg/kg (6-20 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic JTEHD6 66(A),275,2003
oral
rat 		lowest published toxic dose: 45 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic 		TOSCF2 77,83,2004
oral
rabbit 		lowest published toxic dose: 12,180 mg/kg (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FEREAC 60,7509,1995
subcutaneous
rat 		lowest published toxic dose: 200 mL/kg (12 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Central nervous system 		JTEHD6 44,189,1995
subcutaneous
rat 		lowest published toxic dose: 50 mg/kg (12-19 day pregnant) Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus 		PBBHAU 53,771,1996
subcutaneous
rat 		lowest published toxic dose: 200 mg/kg (12-19 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		PBBHAU 53,771,1996
subcutaneous
rat 		lowest published toxic dose: 4 mg/kg (17-20 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Drug dependence 		NETEEC 24,733,2002
subcutaneous
rat 		lowest published toxic dose: 4 mg/kg (9-12 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects 		NETEEC 26,95,2004
skin
rat 		lowest published toxic dose: 30 mg/kg (18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system 		JTEHD6 63,173,2001
skin
rat 		lowest published toxic dose: 1.6 mg/kg (5-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) 		TOXID9 72,127,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >200 mg/m3/4 hour N/R PEMNDP 9,166,1991
intraperitoneal
mouse 		lethal dose (50 percent kill): 192 mg/kg N/R TXAPA9 65,144,1982
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg Brain and Coverings: Other degenerative changes TOLED5 135,89,2002
oral
wild bird 		lethal dose (50 percent kill): 5 mg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 25,400 µg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 11,49,1967
oral
chicken 		lethal dose (50 percent kill): 100 mg/kg N/R HBPTO* 2,957,2001
oral
duck 		lethal dose (50 percent kill): 76 mg/kg N/R TXAPA9 20,57,1971
oral
guinea pig 		lethal dose (50 percent kill): 504 mg/kg N/R FMCHA2 -,C74,1991
oral
human 		lowest published toxic dose: 2 mg/kg Endocrine: Differential effect of sex or castration on observed toxicity

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		TOSCF2 66,34,2002
oral
man 		lowest published toxic dose: 300 mg/kg Peripheral Nerve and Sensation: Paresthesia

Behavioral: Muscle weakness

Behavioral: Coma 		ARTODN 59,176,1986
oral
man 		lowest published toxic dose: 1.71 mL/kg Behavioral: Muscle weakness

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression 		VHTODE 43,34,2001
oral
mouse 		lethal dose (50 percent kill): 60 mg/kg N/R JPFCD2 13,11,1978
oral
pigeon 		lethal dose (50 percent kill): 10 mg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 13,300 µg/kg N/R ASTTA8 (680),157,1979
oral
rat 		lethal dose (50 percent kill): 82 mg/kg N/R TXAPA9 14,515,1969
oral
rat 		lowest published toxic dose: 23.5 mg/kg Brain and Coverings: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NRTXDN 22,39,2001
oral
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Change in motor activity (specific assay) TXCYAC 146,1,2000
oral
rat 		lowest published toxic dose: 25 mg/kg Behavioral: Change in psychophysiological tests TXCYAC 146,1,2000
oral
rat 		lowest published toxic dose: 1 mg/kg Nutritional and Gross Metabolic: Body temperature increase TXCYAC 177,215,2002
oral
rat 		lowest published toxic dose: 5 mg/kg Brain and Coverings: Other degenerative changes TOXID9 72,305,2003
oral
rat 		lowest published lethal dose: 8 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,308,2003
oral
rat 		lowest published toxic dose: 10 mg/kg Nutritional and Gross Metabolic: Body temperature decrease TOXID9 72,308,2003
oral
rat 		lowest published toxic dose: 5 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,309,2003
oral
rat 		lowest published toxic dose: 10 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		TOSCF2 66,34,2002
oral
rat 		lowest published toxic dose: 1.5 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOSCF2 77,63,2004
oral
rabbit 		lethal dose (50 percent kill): 1 gm/kg N/R SPEADM 78-1,45,1978
subcutaneous
guinea pig 		lowest published lethal dose: 100 mg/kg N/R JEENAI 60,733,1967
subcutaneous
rat 		lowest published toxic dose: 60 mg/kg Brain and Coverings: Other degenerative changes TOXID9 72,305,2003
subcutaneous
rat 		lowest published toxic dose: 13.5 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NETEEC 25,599,2003
subcutaneous
rat 		lowest published toxic dose: 45 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain NETEEC 25,599,2003
subcutaneous
rat 		lowest published toxic dose: 166 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NETEEC 26,305,2004
skin
mouse 		lethal dose (50 percent kill): 120 mg/kg N/R YKYUA6 38,745,1987
skin
rat 		lethal dose (50 percent kill): 202 mg/kg N/R TXAPA9 14,515,1969
skin
rat 		lowest published toxic dose: 30 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		JTEHD6 63,173,2001
skin
rabbit 		lethal dose (50 percent kill): 2 gm/kg N/R GUCHAZ 6,203,1973
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 163 mg/kg N/R JAFCAU 27,712,1979
unreported route
rat 		lethal dose (50 percent kill): 150 mg/kg N/R 30ZDA9 -,339,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
chicken 		lowest published toxic dose: 980 mg/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 11,,49,1967
oral
dog 		lowest published toxic dose: 2,190 mg/kg/2 year- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		FCTXAV 12,47,1974
oral
mouse 		lowest published toxic dose: 39.6 mg/kg/30 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		FCTOD7 41,767,2003
oral
mouse 		lowest published toxic dose: 79.2 mg/kg/60 day- continuous Blood: Normocytic anemia

Blood: Luekopenia 		FCTOD7 41,767,2003
oral
rat 		lowest published toxic dose: 730 mg/kg/2 year- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase FCTXAV 12,47,1974
oral
rat 		lowest published toxic dose: 21,840 µg/kg/28 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ESKHA5 (106),48,1988
oral
rat 		lowest published toxic dose: 800 mg/kg/8 week- intermittent Eye: Miosis (pupilliary constriction)

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		TOXID9 36(1,pt2),345,1997
oral
rat 		lowest published toxic dose: 210 mg/kg/2 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOSCF2 55,124,2000
oral
rat 		lowest published toxic dose: 60 mg/kg/4 week- intermittent Eye: Miosis (pupilliary constriction)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NETEEC 22,237,2000
oral
rat 		lowest published toxic dose: 200 mg/kg/4 week- intermittent Behavioral: Tremor

Behavioral: Alteration of operant conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NETEEC 22,237,2000
oral
rat 		lowest published toxic dose: 50 mg/kg/5 day- intermittent Eye: Miosis (pupilliary constriction)

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Body temperature increase 		NETEEC 22,237,2000
oral
rat 		lowest published toxic dose: 50 mg/kg/3 day- intermittent Behavioral: Alteration of operant conditioning

Behavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NETEEC 23,33,2001
oral
rat 		lowest published toxic dose: 57 mg/kg/12 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 59,260,2001
oral
rat 		lowest published toxic dose: 111 mg/kg/21 day- intermittent Behavioral: Change in motor activity (specific assay) TOSCF2 59,260,2001
oral
rat 		lowest published toxic dose: 18 mg/kg/6 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOSCF2 59,260,2001
oral
rat 		lowest published toxic dose: 213 mg/kg/24 week- intermittent Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXCYAC 177,215,2002
oral
rat 		lowest published toxic dose: 127.5 mg/kg/24 week- intermittent Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation TXCYAC 177,215,2002
oral
rat 		lowest published toxic dose: 15 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Body temperature increase TXCYAC 177,215,2002
oral
rat 		lowest published toxic dose: 75 mg/kg/5 day- intermittent Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		REPTED 17,203,2003
oral
rat 		lowest published toxic dose: 75 mg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 17,203,2003
oral
rat 		lowest published toxic dose: 1,820 mg/kg/1 year- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,309,2003
oral
rat 		lowest published toxic dose: 21 mg/kg/21 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,127,2003
oral
rat 		lowest published toxic dose: 119 mg/kg/17 day- intermittent Nutritional and Gross Metabolic: Body temperature increase TXCYAC 177,215,2002
oral
rat 		lowest published toxic dose: 9 mg/kg/5 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOSCF2 76,400,2003
oral
rat 		lowest published toxic dose: 12 mg/kg/4 day- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOSCF2 77,63,2004
oral
rat 		lowest published toxic dose: 4.2 mg/kg/28 day- continuous Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		FCTOD7 42,1269,2004
oral
rat 		lowest published toxic dose: 4.2 mg/kg/28 day- continuous Blood: Other changes FCTOD7 42,1269,2004
oral
rabbit 		lowest published toxic dose: 1,960 mg/kg/13 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 60,7509,1995
subcutaneous
mouse 		lowest published toxic dose: 300 mg/kg/2 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		NRTXDN 23,537,2002
subcutaneous
mouse 		lowest published toxic dose: 300 mg/kg/2 week- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum NRTXDN 23,537,2002
subcutaneous
rat 		lowest published toxic dose: 21 mg/kg/7 day- intermittent Behavioral: Change in psychophysiological tests TXAPA9 174,89,2001
subcutaneous
rat 		lowest published toxic dose: 0.6 mg/kg/5 day- intermittent Behavioral: Change in psychophysiological tests TXAPA9 174,89,2001
subcutaneous
rat 		lowest published toxic dose: 250 mg/kg/7 day- intermittent Behavioral: Alteration of operant conditioning

Behavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NETEEC 23,33,2001
subcutaneous
rat 		lowest published toxic dose: 120 mg/kg/1 hour/4 week- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ARTODN 75,480,2001
subcutaneous
rat 		lowest published toxic dose: 120 mg/kg/42 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,305,2003
skin
rat 		lowest published toxic dose: 26 mg/kg/13 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 72,89,2003
unreported route
rat 		lowest published toxic dose: 4 mg/kg/4 day- intermittent Brain and Coverings: Recordings from specific areas of CNS TOXID9 72,124,2003
unreported route
rat 		lowest published toxic dose: 10.5 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,309,2003
unreported route
rat 		lowest published toxic dose: 15 mg/kg/5 day- intermittent Brain and Coverings: Other degenerative changes TOXID9 72,309,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
TOLED5 127,29,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,99,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - POLAND time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORPYRIFOS-air 10 hour time-weighted average 0.2 mg/m3;
short term exposure limit 0.6 mg/m3 (Sk) 		NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4463;
Number of Industries 1;
Total Number of Facilities 753;
Number of Occupations 3;
Total Number of Employees Exposed 22,523
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0714;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 7
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4463;
Number of Industries 4;
Total Number of Facilities 1,276;
Number of Occupations 3;
Total Number of Employees Exposed 11,404;
Total Number of Female Employees Exposed 842


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/103088/AS)
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used for control of fire ants, turf and ornamental plant insects, mosquitoes, etc.
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
OSHA ANALYTICAL METHOD #62


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
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Used for control of fire ants, turf and ornamental plant insects, mosquitoes, etc.

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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