The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - diethyl O - (p - nitrophenyl) ester

RTECS #: TF4550000

CAS #: 56-38-2

UPDATE: May 2005 MW: 291.28 MF: C10H14NO5PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. AATP
  2. Alkron
  3. Alleron
  4. American cyanamid 3422
  5. Aphamite
  6. Aralo
  7. B 404
  8. BAY E - 605
  9. Bay 1605
  10. Bayer E - 605
  11. Bladan F
  12. Compound 3422
  13. Diethyl 4 - nitrophenyl phosphorothionate
  14. Diethyl p - nitrophenyl phosphorothionate
  15. Diethyl p - nitrophenyl thionophosphate
  16. Diethyl p - nitrophenyl thiophosphate
  17. Diethyl para - nitrophenol thiophosphate
  18. Diethylparathion
  19. Dietil tiofosfato de p - nitrofenila (Portuguese)
  20. Drexel parathion 8E
  21. E 605
  22. E 605 F
  23. E 605 forte
  24. ENT 15,108
  25. Ekatin WF & WF ULV
  26. Ekatox
  27. Ethyl parathion
  28. Etilon
  29. Etylparation (Czech)
  30. Folidol
  31. Folidol E
  32. Folidol E605
  33. Folidol oil
  34. Fosferno
  35. Fosfex
  36. Fostern
  37. Gearphos
  38. Kolphos
  39. Lethalaire G - 54
  40. Lirothion
  41. Murfos
  42. NCI - C00226
  43. NIUIF - 100
  44. Niran
  45. Niran E - 4
  46. Nitrostigmin (German)
  47. Nitrostigmine
  48. Nourithion
  49. O,O - Diaethyl - O - (4 - nitro - phenyl) - monothiophosphat (German)
  50. O,O - Diethyl O - (p - nitrophenyl) phosphorothioate
  1. O,O - Diethyl O - 4 - nitrophenyl thiophosphate
  2. O,O - Diethyl O - p - nitrophenyl thiophosphate
  3. O,O - Diethyl - O - (4 - nitro - fenil) - monothiofosfaat (Dutch)
  4. O,O - Diethyl - O - (4 - nitrophenyl) phosphorothioate
  5. O,O - Diethyl - O - (p - nitrophenyl) thionophosphate
  6. O,O - Diethyl - O - p - nitrofenylester kyseliny thiofosforecne (Czech)
  7. O,O - Dietil - O - (4 - nitro - fenil) - monotiofosfato (Italian)
  8. O,O - Dietyl - O - p - nitrofenyltiofosfat (Czech)
  9. OMS 19
  10. Oleofos 20
  11. Oleoparaphene
  12. Oleoparathion
  13. Orthophos
  14. Pacol
  15. Panthion
  16. Paradust
  17. Paramar 50
  18. Paraphos
  19. Parathene
  20. Parathion
  21. Parathion (ACGIH:OSHA)
  22. Parathion - aethyl (German)
  23. Parathion - ethyl
  24. Parawet
  25. Penncap E
  26. Pestox plus
  27. Pethion
  28. Phenol, p - nitro - , O - ester with O,O - diethylphosphorothioate
  29. Phoskil
  30. Phosphemol
  31. Phosphenol
  32. Phosphorothioic acid, O,O - diethyl O - (4 - nitrophenyl) ester
  33. Phosphostigmine
  34. RB
  35. RCRA waste number P089
  36. Rhodiasol
  37. Rhodiatox
  38. SNP
  39. Selephos
  40. Soprathion
  41. Stabilized ethyl parathion
  42. Super Rodiatox
  43. T - 47
  44. Thiofos
  45. Thiomex
  46. Thiophos
  47. Thiophos 3422
  48. Thiophosphate de O,O - diethyle et de O - (4 - nitrophenyle) (French)
  49. Vitrex


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage oral
mouse 		20 mg/kg/28 day- intermittent MUREAV 53,175,1978
DNA damage intraperitoneal
mouse 		3 µg/kg MUREAV 53,175,1978
DNA damage mouse lymphocyte 10 µmol/L/16 hour JAPTO* 23,23,2003
DNA damage oral
rat 		10 mg/kg/28 day- intermittent MUREAV 53,175,1978
DNA damage intraperitoneal
rat 		3 µg/kg MUREAV 53,175,1978
DNA damage rat lymphocyte 10 µmol/L/16 hour JAPTO* 23,23,2003
unscheduled DNA synthesis human fibroblast 10 µmol/L NTIS** PB268-647
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 500 µg/plate (-enzymatic activation step) JTEHD6 16,403,1985
sister chromatid exchange hamster ovary 300 µmol/L JTEHD6 8,939,1981
sister chromatid exchange human lymphocyte 200 µg/L MUREAV 102,89,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 3 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) AEHLAU 16,805,1968
intraperitoneal
rat 		lowest published toxic dose: 3 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AEHLAU 16,805,1968
intraperitoneal
rat 		lowest published toxic dose: 3,500 µg/kg (11 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) AEHLAU 16,805,1968
intraperitoneal
rat 		lowest published toxic dose: 980 µg/kg (9 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		AJOGAH 96,1148,1966
oral
rat 		lowest published toxic dose: 360 µg/kg (2-22 day pregnant/15 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects 		TOLED5 3,11,1979
oral
rat 		lowest published toxic dose: 2,304 µg/kg (16 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina TOERD9 3,279,1981
oral
rat 		lowest published toxic dose: 22 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic JJATDK 9,401,1989
subcutaneous
rat 		lowest published toxic dose: 6 mg/kg (13-16 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) PWPSA8 16,141,1973
subcutaneous
rat 		lowest published toxic dose: 9,800 µg/kg (7-13 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death OYYAA2 6,667,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,260 mg/kg/80 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors 		NCITR* NCI-TR-70,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration : >37,130 µg/m3/4 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NTIS** AD-A041-973
inhalation
guinea pig 		lowest published lethal concentration: 14 mg/m3/2 hour N/R AMIHBC 5,44,1952
inhalation
mouse 		lowest published lethal concentration: 15 mg/m3 N/R 85GMAT -,52,1982
inhalation
rat 		lethal concentration (50 percent kill): 84 mg/m3/4 hour Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		NTIS** AD-A041-973
inhalation
rabbit 		lowest published lethal concentration: 50 mg/m3/2 hour N/R AMIHBC 5,44,1952
intramuscular
domestic animal 		lowest published lethal dose: 20 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Behavioral: Rigidity (includes catalepsy) 		MRLR** #269,1954
intramuscular
mouse 		lethal dose (50 percent kill): 7,200 µg/kg N/R AEPPAE 237,211,1959
intramuscular
rat 		lethal dose (50 percent kill): 6 mg/kg N/R JCINAO 37,350,1958
intraperitoneal
cat 		lethal dose (50 percent kill): 3 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		JPETAB 95,79,1949
intraperitoneal
chicken 		lethal dose (50 percent kill): 2,500 µg/kg N/R EQSFAP 3,173,1974
intraperitoneal
dog 		lethal dose (50 percent kill): 12 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		JPETAB 95,79,1949
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 12 mg/kg N/R ARZNAD 5,626,1955
intraperitoneal
mouse 		lethal dose (50 percent kill): 3 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAFCAU 11,91,1963
intraperitoneal
rat 		lethal dose (50 percent kill): 2 mg/kg N/R APCRAW 4,117,1961
intratracheal
human 		lowest published lethal dose: 714 µg/kg N/R SKEZAP 9,1,1968
intratracheal
rat 		lethal dose (50 percent kill): 6,200 µg/kg N/R JJATDK 19,133,1999
intravenous
cat 		lethal dose (50 percent kill): 3 mg/kg Eye: Lacrimation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		JAMAAP 144,104,1950
intravenous
dog 		lethal dose (50 percent kill): 12 mg/kg Eye: Lacrimation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		JAMAAP 144,104,1950
intravenous
mouse 		lethal dose (50 percent kill): 13 mg/kg N/R TXAPA9 22,684,1972
intravenous
rat 		lethal dose (50 percent kill): 3,800 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases CJBPAZ 34,197,1956
oral
wild bird 		lethal dose (50 percent kill): 1,330 µg/kg N/R ASTTA8 (680),157,1979
oral
cat 		lethal dose (50 percent kill): 930 µg/kg N/R ABCHA6 25,605,1961
oral
chicken 		lethal dose (50 percent kill): 10 mg/kg N/R EQSFAP 3,173,1974
oral
duck 		lethal dose (50 percent kill): 2,100 µg/kg N/R DOEAAH 35,25,1979
oral
dog 		lethal dose (50 percent kill): 3 mg/kg N/R SPEADM 78-1,33,1978
oral
domestic animal 		lowest published lethal dose: 100 mg/kg Behavioral: Excitement

Behavioral: Rigidity (includes catalepsy)

Lung, Thorax, or Respiration: Dyspnea 		MRLR** #269,1954
oral
guinea pig 		lethal dose (50 percent kill): 8 mg/kg N/R ARZNAD 5,626,1955
oral
human 		lowest published lethal dose: 171 µg/kg N/R CMEP** -,1,1956
oral
human 		lethal dose (50 percent kill): 3 mg/kg N/R 85JFAN A311,1986
oral
horse, donkey 		lethal dose (50 percent kill): 5 mg/kg N/R 85DPAN -,-,1971/1976
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 49 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		NTIS** PB288-416
oral
man 		lowest published toxic dose: 2,143 mg/kg Behavioral: Coma

Cardiac: Pulse rate decreased with fall in BP

Vascular: Shock 		NEURAI 31,603,1981
oral
man 		lowest published toxic dose: 214 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma 		JNNPAU 56,1135,1993
oral
man 		lowest published toxic dose: 429 µg/kg/4 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 14,603,1969
oral
mouse 		lethal dose (50 percent kill): 5 mg/kg N/R ABCHA6 30,181,1966
oral
pigeon 		lethal dose (50 percent kill): 1,330 µg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 4,040 µg/kg N/R PCBPBS 7,28,1977
oral
quail 		lowest published toxic dose: 5 mg/kg Endocrine: Change in LH CBCPAI 83C,451,1986
oral
quail 		lowest published lethal dose: 10 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Eye: Lacrimation

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		CBCPAI 83C,451,1986
oral
rat 		lethal dose (50 percent kill): 2 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 11,546,1967
oral
rat 		lowest published lethal dose: 0.5 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,308,2003
oral
rabbit 		lethal dose (50 percent kill): 10 mg/kg N/R SPEADM 78-1,33,1978
oral
woman 		lowest published lethal dose: 2,350 µL/kg Behavioral: Coma

Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory depression 		HETOEA 17,587,1998
oral
woman 		lowest published toxic dose: 2 mL/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Behavioral: Coma 		JTCTDW 31,497,1993
oral
woman 		lowest published toxic dose: 5,670 µg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea 		ANYAA9 160,383,1969
parenteral
frog 		lethal dose (50 percent kill): 967 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes 		AIPTAK 124,212,1960
subcutaneous
guinea pig 		lethal dose (50 percent kill): 10 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TPKVAL 7,122,1965
subcutaneous
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R PHARAT 37,729,1982
subcutaneous
rat 		lethal dose (50 percent kill): 9 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TPKVAL 7,122,1965
subcutaneous
rat 		lowest published toxic dose: 0.63 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NETEEC 25,599,2003
subcutaneous
rat 		lowest published toxic dose: 2.1 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain NETEEC 25,599,2003
subcutaneous
rabbit 		lethal dose (50 percent kill): 30 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TPKVAL 7,122,1965
skin
wild bird 		lethal dose (50 percent kill): 1,800 µg/kg N/R TXAPA9 26,154,1973
skin
duck 		lethal dose (50 percent kill): 28 mg/kg N/R TXAPA9 47,451,1979
skin
guinea pig 		lethal dose (50 percent kill): 45 mg/kg N/R AMCYC* 8/1966
skin
human 		lowest published lethal dose: 7,143 µg/kg N/R SKEZAP 9,1,1968
skin
mouse 		lethal dose (50 percent kill): 19 mg/kg N/R ABCHA6 26,257,1962
skin
rat 		lethal dose (50 percent kill): 6,800 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		TXAPA9 2,88,1960
skin
rabbit 		lethal dose (50 percent kill): 15 mg/kg N/R AMCYC* 8/1966
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 6 mg/kg N/R 30ZDA9 -,323,1971
unreported route
man 		lowest published lethal dose: 1,471 µg/kg N/R 85DCAI 2,73,1970
unreported route
mouse 		lethal dose (50 percent kill): 14,500 µg/kg N/R GTPZAB 7(5),38,1963
unreported route
rat 		lowest published toxic dose: 1 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,309,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 200 µg/m3/7 hour/6 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NTIS** AD-A041-973
inhalation
rat 		lowest published toxic concentration: 740 µg/m3/7 hour/6 week- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NTIS** AD-A041-973
oral
chicken 		lowest published toxic dose: 1,800 µg/kg/18 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOLED5 37,279,1987
oral
duck 		lowest published toxic dose: 92,500 µg/kg/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		RREVAH 81,1,1981
oral
dog 		lowest published toxic dose: 15 mg/kg/6 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NTIS** AD-A041-973
oral
dog 		lowest published toxic dose: 145 mg/kg/26 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JJATDK 14,145,1994
oral
dog 		lowest published toxic dose: 7.9 mg/kg/168 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 1,59,2001
oral
human 		lowest published toxic dose: 4.2 mg/kg/42 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 1,59,2001
oral
mammal (species unspecified) 		lowest published toxic dose: 1,394 mg/kg/30 day- continuous Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** PB288-416
oral
mouse 		lowest published toxic dose: 5.6 mg/kg/14 day- continuous Brain and Coverings: Other degenerative changes HBPTO* 2,1026,2001
oral
pig 		lowest published toxic dose: 196 mg/kg/49 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HBPTO* 1,59,2001
oral
rat 		lowest published toxic dose: 10,500 mg/kg/28 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		TXAPA9 18,607,1971
oral
rat 		lowest published toxic dose: 788 mg/kg/15 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 2,523,1960
oral
rat 		lowest published toxic dose: 234 mg/kg/90 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		ENVRAL 17,1,1978
oral
rat 		lowest published toxic dose: 182 mg/kg/26 week- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JPFCD2 16,1,1981
oral
rat 		lowest published toxic dose: 21.84 mg/kg/84 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HBPTO* 1,59,2001
oral
rat 		lowest published toxic dose: 901.6 mg/kg/112 week- continuous Endocrine: Adrenal cortex tumors HBPTO* 1,814,2001
subcutaneous
guinea pig 		lowest published toxic dose: 420 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 7,122,1965
subcutaneous
mouse 		lowest published toxic dose: 12 mg/kg/6 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 25,582,1973
subcutaneous
rat 		lowest published toxic dose: 32,500 µg/kg/21 day- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOLED5 73,33,1994
subcutaneous
rat 		lowest published toxic dose: 378 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 7,122,1965
subcutaneous
rabbit 		lowest published toxic dose: 1,260 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 7,122,1965
unreported route
rat 		lowest published toxic dose: 16 mg/kg/16 day- intermittent Brain and Coverings: Other degenerative changes

Reproductive: Specific developmental abnormalities: Central nervous system 		HBPTO* 2,1029,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,153,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,153,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
ANAEA3 35,165,1975
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
MZUZA8 (8),90,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
ECMAAI 14,141,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,118,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,195,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg/m3, sKIN, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 0.11 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PARATHION-air 10 hour time-weighted average 0.05 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 53920;
Number of Industries 1;
Total Number of Facilities 43;
Number of Occupations 4;
Total Number of Employees Exposed 302


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as a broad spectrum insecticide in agricultural applications
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
NCI Carcinogenesis Bioassay (feed);clear evidence:rat NCITR* NCI-TR-70,1979
NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* NCI-TR-70,1979
OSHA ANALYTICAL METHOD #ID-62


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
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Used as a broad spectrum insecticide in agricultural applications

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 8057-70-3
ALT CAS #: 11111-91-4
ALT CAS #: 110616-89-2
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