The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - diethyl O - (p - (methylsulfinyl) phenyl) ester

RTECS #: TF3850000

CAS #: 115-90-2

UPDATE: November 2004 MW: 308.37 MF: C11H17O4PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. BAY 25141
  2. Bayer 25141
  3. Chemagro 25141
  4. Daconit
  5. Dasanit
  6. ENT 24,945
  7. Fensulfothion
  8. Fensulfothion (ACGIH)
  9. O,O - Diaethyl - O - (4 - methylsulfinyl - phenyl) - thionophosphat (German)
  1. O,O - Diaethyl - O - 4 - methylsulfinyl - phenyl - monothiophosphat (German)
  2. O,O - Diethyl O - (p - (methylsulfinyl) phenyl) phosphorothioate
  3. O,O - Diethyl O - p - (methylsulfinyl) phenyl thiophosphate
  4. OMS 37
  5. Phenol, p - (methylsulfinyl) - , O - ester with O,O - diethyl phosphorothioate
  6. S 767
  7. Terracur P
  8. VUAgT 108
  9. VUAgT 96


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lethal dose (50 percent kill): 2 mg/kg N/R PCBPBS 8,302,1978
inhalation
rat 		lethal concentration (50 percent kill): 113 mg/m3/1 hour N/R 85JFAN A202,1983
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 5,400 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 6,78,1964
intraperitoneal
mouse 		lethal dose (50 percent kill): 7 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 6,78,1964
intraperitoneal
rat 		lethal dose (50 percent kill): 1,500 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 6,78,1964
oral
wild bird 		lethal dose (50 percent kill): 240 µg/kg N/R TXAPA9 21,315,1972
oral
duck 		lethal dose (50 percent kill): 747 µg/kg N/R TXAPA9 22,556,1972
oral
guinea pig 		lethal dose (50 percent kill): 9 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 6,78,1964
oral
pigeon 		lethal dose (50 percent kill): 560 µg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 1,200 µg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		EESADV 8,551,1984
oral
rat 		lethal dose (50 percent kill): 2,200 µg/kg N/R TXAPA9 6,78,1964
skin
wild bird 		lethal dose (50 percent kill): 420 µg/kg N/R TXAPA9 26,154,1973
skin
duck 		lethal dose (50 percent kill): 3 mg/kg N/R TXAPA9 47,451,1979
skin
rat 		lethal dose (50 percent kill): 3 mg/kg N/R WRPCA2 9,119,1970
unreported route
rat 		lethal dose (50 percent kill): 11 mg/kg N/R 30ZDA9 -,337,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg/60 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 6,78,1964


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,120,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FENSULFOTHION-air 10 hour time-weighted average 0.1 mg/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
Used to control parasitic, sedentary and free-living nematodes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used to control parasitic, sedentary and free-living nematodes

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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