The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - diethyl O - (2 - (ethylthio) ethyl) ester, mixed with O,O - diethyl S - (2 - (ethylthio) ethyl) phosphorothioate (7:3)

RTECS #: TF3150000

CAS #: 8065-48-3

UPDATE: November 2004 MW: 516.72 MF: C8H19O3PS2•C8H19O3PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bayer 8169
  2. Diethoxy thiophosphoric acid ester of 2 - ethylmercaptoethanol
  3. O,O - Diethyl 2 - ethylmercaptoethyl thiophosphate
  4. O,O - Diethyl O (and S) - 2 - (ethylthio) ethyl phosphorothioate mixture
  5. Ethyl systox
  6. Demeton
  7. Demeton (ACGIH:OSHA)
  1. E 1059
  2. ENT 17,295
  3. Mercaptofos
  4. Mercaptophos
  5. Septox
  6. Systox
  7. Systox (OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Saccharomyes cerevisiae 500 ppm (+/-enzymatic activation step) NTIS** PB84-138973
gene conversion and mitotic recombination Saccharomyes cerevisiae 500 ppm NTIS** PB84-138973
mutation in mammalian somatic cells mouse lymphocyte 80 mg/L NTIS** PB84-138973
sister chromatid exchange hamster ovary 25 ppm NTIS** PB84-138973
sister chromatid exchange hamster lung 10 mg/L MUREAV 88,307,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TXAPA9 24,324,1973
parenteral
mouse 		lowest published toxic dose: 10 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ANREAK 169,285,1971
parenteral
mouse 		lowest published toxic dose: 7 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Gastrointestinal system ANREAK 169,285,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 15 mg/m3/4 hour N/R 85GMAT -,52,1982
inhalation
rat 		lowest published lethal concentration: 15 mg/m3/4 hour N/R 85GMAT -,52,1982
intramuscular
cat 		lethal dose (50 percent kill): 3,900 µg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		13ZGAF -,220,1962
intramuscular
dog 		lethal dose (50 percent kill): 3,650 µg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		13ZGAF -,220,1962
intramuscular
rat 		lowest published lethal dose: 3 mg/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting 		13ZGAF -,220,1962
intraperitoneal
mouse 		lethal dose (50 percent kill): 4 mg/kg N/R PSEBAA 129,699,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 2,500 µg/kg N/R APCRAW 4,117,1961
intraperitoneal
rabbit 		lethal dose (50 percent kill): 3,250 µg/kg N/R BLLIAX 38,151,1958
intravenous
mouse 		lethal dose (50 percent kill): 3,900 µg/kg N/R BLLIAX 38,151,1958
intravenous
rat 		lethal dose (50 percent kill): 1,750 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		BLLIAX 38,151,1958
oral
wild bird 		lethal dose (50 percent kill): 1,780 µg/kg N/R ASTTA8 (680),157,1979
oral
duck 		lethal dose (50 percent kill): 7,190 µg/kg N/R TXAPA9 47,451,1979
oral
human 		lowest published lethal dose: 171 µg/kg N/R CMEP** -,1,1956
oral
man 		lowest published toxic dose: 144 mg/kg/24 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 14,603,1969
oral
mouse 		lethal dose (50 percent kill): 7,850 µg/kg N/R BLLIAX 38,151,1958
oral
pigeon 		lethal dose (50 percent kill): 8,480 µg/kg N/R TXAPA9 20,57,1971
oral
quail 		lethal dose (50 percent kill): 8,480 µg/kg N/R TXAPA9 20,57,1971
oral
rat 		lethal dose (50 percent kill): 1,700 µg/kg N/R TXAPA9 21,315,1972
oral
rabbit 		lethal dose (50 percent kill): 5 mg/kg N/R GISAAA 27(8),97,1962
subcutaneous
mouse 		lethal dose (50 percent kill): 15 mg/kg N/R APFRAD 11,286,1953
subcutaneous
rabbit 		lethal dose (50 percent kill): 24 mg/kg N/R IAEC** 17JUN1974
skin
wild bird 		lethal dose (50 percent kill): 1,800 µg/kg N/R TXAPA9 26,154,1973
skin
rat 		lethal dose (50 percent kill): 8,200 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		TXAPA9 2,88,1960
skin
rabbit 		lethal dose (50 percent kill): 24 mg/kg N/R SPEADM 78-1,28,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 7.9 mg/kg/168 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HBPTO* 1,59,2001
oral
human 		lowest published toxic dose: 1.2 mg/kg/24 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 1,59,2001
oral
rat 		lowest published toxic dose: 15.68 mg/kg/112 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HBPTO* 1,59,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin) ( intermittent,V) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
DTTIAF 80,485,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,109,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.01 ppm (0.1 mg/m3) (skin) DTLWS* 3,15,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 ppm (0.1 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.01 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 ppm (0.11 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.01 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - INDIA time-weighted average 0.01 ppm (0.1 mg/m3), Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.02 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 mg/m3 (skin) ( intermittent,V)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 mg/m3 (skin) ( intermittent,V)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DEMETON-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; D melanogaster Sex-linked lethal
Used as an insecticide
On EPA IRIS database
NIOSH Analytical Method, 1994: Demeton, 5514


REFERENCES:

CODEN
REFERENCE
13ZGAF "Gigiena i Toksikologiya Novykh Pestitsidov i Klinika Otravlenii, Doklady Vsesoyuznoi Konferentsii, 2nd, 1962," Hygiene and Toxicology of New Pesticides and Clinical Aspects of Poisoning, Medved, L.I., et al., eds., Komiteta Po Izucheniiu i Reglamenta-tsii Indokhimikatov Glavnoi Gosudarstvennoi Sanitarnoi Inspectsii USSR, 1962
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943-
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BLLIAX Bratislavske Lekarske Listy. (PNS-Ustredna Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava, Czechoslovakia) V.1- 1921-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 8000-97-3
ALT CAS #: 8058-73-9
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