The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - diethyl S - (2 - (ethylthio) ethyl) ester

RTECS #: TF3130000

CAS #: 126-75-0

UPDATE: October 1997 MW: 258.36 MF: C8H19O3PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. STATUS IN FEDERAL AGENCIES:
  4. REFERENCES:

SYNONYMS:

  1. Diethyl S - (2 - ethioethyl) thiophosphate
  2. O,O - Diethyl S - (2 - eththioethyl) phosphorothioate
  3. O,O - Diethyl S - ethyl - 2 - ethylmercaptophosphorothiolate
  4. O,O - Diethyl - S - (2 - ethylthio - ethyl) - monothiofosfaat (Dutch)
  5. O,O - Diethyl S - 2 - (ethylthio) ethyl phosphorothioate
  6. O,O - Diethyl S - (2 - (ethylthio) ethyl) phosphorothiolate
  7. O,O - Dietil - S - (2 - etiltio - etil) - monotiofosfato (Italian)
  8. O,O - Dietyl - S - 2 - etylmerkaptoetyltiofosfat (Czech)
  9. Demeton - S
  1. O,O - Diaethyl - S (2 - aethylthio - aethyl) - monothiophosphat (German)
  2. Ethanethiol, 2 - (ethylthio) - , S - ester with O,O - diethyl phosphorothioate
  3. Isodemeton
  4. Isosystox
  5. Izosystox (Czech)
  6. PO - Systox
  7. Thioldemeton
  8. Thiol systox
  9. Thiophosphate de O,O - diethyle et de S - (2 - ethylthio - ethyle) (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 5,500 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase AMIHAB 13,606,1956
intraperitoneal
mouse 		lethal dose (50 percent kill): 174 µg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) PHARAT 35,806,1980
intraperitoneal
rat 		lethal dose (50 percent kill): 1,500 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase AMIHAB 13,606,1956
intravenous
rat 		lethal dose (50 percent kill): 1,700 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase BCPCA6 6,244,1961
oral
mouse 		lowest published lethal dose: 5,800 µg/kg N/R GTPZAB 2(5),7,1958
oral
rat 		lethal dose (50 percent kill): 1,500 µg/kg N/R AEPPAE 217,144,1953
subcutaneous
mouse 		lethal dose (50 percent kill): 6 mg/kg N/R AEPPAE 217,144,1953
skin
rabbit 		lowest published lethal dose: 5 mg/kg N/R GTPZAB 2(5),7,1958
unreported route
mouse 		lethal dose (50 percent kill): 5,600 µg/kg N/R GTPZAB 7(5),38,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946-

RTECS Compound Description:
   Agricultural Chemical
   Drug

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