The Registry of Toxic Effects of Chemical Substances
Phosphorodithioic acid, S,S' - methylene O,O,O',O' - tetraethyl ester |
UPDATE: November 2004 | MW: 384.49 | MF: C9H22O4P2S4 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lethal concentration (50 percent kill): 864 mg/m3
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N/R
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FMCHA2 -,C128,1991
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intraperitoneal | mouse
lethal dose (50 percent kill): 35 mg/kg
|
N/R
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PSEBAA 129,699,1968
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intraperitoneal | rat
lethal dose (50 percent kill): 26 mg/kg
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N/R
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PSEBAA 129,699,1968
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oral | wild bird
lethal dose (50 percent kill): 45 mg/kg
|
N/R
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TXAPA9 21,315,1972
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oral | guinea pig
lethal dose (50 percent kill): 40 mg/kg
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N/R
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85DPAN -,-,1971/1976
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oral | human
lowest published toxic dose: 100 µg/kg
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Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
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TXAPA9 22,286,1972
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oral | infant
lowest published toxic dose: 15,700 µg/kg
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Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature increase
TXMDAX 63,71,1967
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oral | mouse
lethal dose (50 percent kill): 40 mg/kg
|
N/R
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85DPAN -,-,1971/1976
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oral | rat
lethal dose (50 percent kill): 13 mg/kg
|
N/R
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PHJOAV 185,361,1960
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skin | guinea pig
lethal dose (50 percent kill): 915 mg/kg
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N/R
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85DPAN -,-,1971/1976
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skin | rat
lethal dose (50 percent kill): 62 mg/kg
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N/R
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TXAPA9 14,515,1969
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unreported route | rat
lethal dose (50 percent kill): 55 mg/kg
|
N/R
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30ZDA9 -,367,1971
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | dog
lowest published toxic dose: 675 mg/kg/90 day- continuous
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Blood: Other changes | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 8,173,1988
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oral | dog
lowest published toxic dose: 182 mg/kg/1 year- continuous
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Blood: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 8,173,1988
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REVIEWS:
ORGANIZATION
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STANDARD
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|
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 0.05 mg/m3 (skin) ( intermittent,V)
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DTLVS* TLV/BEI,2003
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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Not Classifiable as a Human Carcinogen
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DTLVS* TLV/BEI,2003
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TOXICOLOGY REVIEW
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AQMOAC #73-19,1973
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TOXICOLOGY REVIEW
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DTTIAF 80,485,1973
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TOXICOLOGY REVIEW
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RREVAH 63,1,1976
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
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PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
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FEREAC 54,7740,1989
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Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: Supported
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RBREV* -,117,1998
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 0.4 mg/m3, Skin, JAN1993
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Occupational Exposure Limit - BELGIUM
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time-weighted average 0.4 mg/m3, Skin, JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 0.4 mg/m3, Skin, JAN1999
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Occupational Exposure Limit - FRANCE
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VME 0.4 mg/m3, Skin, JAN1999
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 0.4 mg/m3, Skin, JAN1999
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 0.4 mg/m3, Skin, 2003
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Not Classifiable as a Human Carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHION-air
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10 hour time-weighted average 0.4 mg/m3 (Sk)
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NIOSH* DHHS #95-121,1995
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 84542; |
Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108024)
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EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
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EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
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EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
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EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
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Used as an insecticide and acaricide
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
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REFERENCES:
CODEN
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REFERENCE
30ZDA9
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"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
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85DPAN
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"Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin,
Verlag Paul Parey, 1971-1976
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AQMOAC
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Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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DTTIAF
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Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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FMCHA2
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Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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PHJOAV
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Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London,
SE1 7JN, UK) V.131- 1933-
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PSEBAA
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Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1903/04-
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RBREV*
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Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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RREVAH
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Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1962-
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TOXID9
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Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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TXAPA9
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Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
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TXMDAX
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Texas Medicine. (Texas Medical Assoc., 1801 N. Lamar Blvd., Austin, TX 78701) V.60- 1964-
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