The Registry of Toxic Effects of Chemical Substances

Phosphorodithioic acid, O - ethyl O - (4 - (methylthio) phenyl) S - propyl ester

RTECS #: TE4165000

CAS #: 35400-43-2

UPDATE: November 2004 MW: 322.46 MF: C12H19O2PS3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. BAY - NTN - 9306
  2. Bolstar
  3. Helothion
  4. NTN 9306
  5. O - Ethyl O - (4 - (methylmercapto) phenyl) - S - n - propylphosphorothionothiolate
  1. O - Ethyl O - (4 - (methylthio) phenyl) S - propyl phosphorodithioate
  2. O - Ethyl O - (4 - (methylthio) phenyl) phosphorodithioic acid S - propyl ester
  3. Sulprofos
  4. Sulprofos (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 300 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NNGADV 12,775,1987
oral
rabbit 		lowest published toxic dose: 390 mg/kg (6-18 day pregnant) Reproductive: Other effects on female NNGADV 12,775,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >661 mg/m3/4 hour N/R NNGADV 12,775,1987
intraperitoneal
mouse 		lethal dose (50 percent kill): 280 mg/kg N/R NNGADV 12,775,1987
intraperitoneal
rat 		lethal dose (50 percent kill): 160 mg/kg N/R NNGADV 12,775,1987
oral
chicken 		lethal dose (50 percent kill): 65 mg/kg N/R 85INA8 6,1473,1991
oral
mouse 		lethal dose (50 percent kill): 490 mg/kg N/R NNGADV 12,775,1987
oral
rat 		lethal dose (50 percent kill): 65 mg/kg N/R 85ARAE 1,205,1977
subcutaneous
mouse 		lethal dose (50 percent kill): >1 gm/kg N/R NNGADV 12,775,1987
subcutaneous
rat 		lethal dose (50 percent kill): 490 mg/kg N/R NNGADV 12,775,1987
skin
mouse 		lethal dose (50 percent kill): 5 gm/kg N/R NNGADV 12,775,1987
skin
rat 		lethal dose (50 percent kill): 2,500 mg/kg N/R NNGADV 12,775,1987
skin
rabbit 		lethal dose (50 percent kill): 820 mg/kg N/R FMCHA2 -,C47,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
chicken 		lowest published toxic dose: 29,610 µg/kg/45 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Ataxia

Musculoskeletal: Other changes 		EVMJB9 49,115,1989
oral
dog 		lowest published toxic dose: 455 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		NNGADV 12,775,1987
oral
dog 		lowest published toxic dose: 1,825 mg/kg/2 year- continuous Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NNGADV 12,775,1987
oral
mouse 		lowest published toxic dose: 2,079 mg/kg/99 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NNGADV 12,775,1987
oral
rat 		lowest published toxic dose: 54,600 µg/kg/13 week- continuous Blood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NNGADV 12,775,1987
oral
rat 		lowest published toxic dose: 2,628 mg/kg/2 year- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NNGADV 12,775,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,150,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SULPROFOS-air 10 hour time-weighted average 1 mg/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


REFERENCES:

CODEN
REFERENCE
85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVMJB9 Journal of the Egyptian Veterinary Medical Association. (Egyptian Veterinary Medical Association, 8, 26 July St., Cairo, Egypt) V.27- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used for control of certain lepidopterous, dipterous and hemipterous insects on cotton, etc.

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

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