The Registry of Toxic Effects of Chemical Substances

Phosphorodithioic acid, S,S' - p - dioxane - 2,3 - diyl O,O,O',O' - tetraethyl ester

RTECS #: TE3350000

CAS #: 78-34-2

UPDATE: November 2004 MW: 456.56 MF: C12H26O6P2S4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Delnatex
  2. Delnav
  3. Deltic
  4. 2,3 - p - Dioxane S,S - bis (O,O - diethylphosphorodithioate)
  5. p - Dioxane - 2,3 - dithiol, S,S - diester with O,O - diethyl phosphorodithioate
  6. p - Dioxane - 2,3 - diyl ethyl phosphorodithioate
  7. 1,4 - Diossan - 2,3 - diyl - bis (O,O - dietil - ditiofosfato) (Italian)
  8. 1,4 - Dioxaan - 2,3 - diyl - bis (O,O - diethyl - dithiofosfaat) (Dutch)
  9. 2,3 - P - Dioxan - S,S' - bis (O,O - diaethyldithiophosphat) (German)
  10. 2,3 - p - Dioxandithiol S,S - bis (O,O - diethyl phosphorodithioate)
  11. 1,4 - Dioxan - 2,3 - diyl - bis (O,O - diaethyl - dithiophosphat) (German)
  12. 1,4 - Dioxan - 2,3 - diyl bis (O,O - diethylphosphorothiolothionate)
  13. 1,4 - Dioxan - 2,3 - diyl O,O,O',O' - tetraethyl di (phosphoromithioate)
  14. Dioxane phosphate
  1. Dioxathion
  2. Dioxathion (ACGIH)
  3. Dioxation
  4. Dioxothion
  5. ENT 22,897
  6. AC 528
  7. Bis (dithiophosphate de O,O - diethyle) de S,S' - (1,4 - dioxanne - 2,3 - diyle) (French)
  8. Hercules 528
  9. Hercules AC528
  10. Kavadel
  11. Navadel
  12. NCI - C00395
  13. Phosphorodithioic acid, S,S' - 1,4 - dioxane - 2,3 - diyl O,O,O',O' - tetraethyl ester (9CI)
  14. Ruphos


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 6,667 µg/plate (+enzymatic activation step) ENMUDM 8(Suppl 7),1,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 340 mg/m3/1 hour Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 5,605,1963
inhalation
rat 		lethal concentration (50 percent kill): 1,398 mg/m3/1 hour Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 5,605,1963
intraperitoneal
mouse 		lethal dose (50 percent kill): 33 mg/kg N/R PSEBAA 129,699,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 30 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 5,605,1963
oral
chicken 		lethal dose (50 percent kill): >316 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		TXAPA9 5,605,1963
oral
dog 		lethal dose (50 percent kill): 10 mg/kg N/R PCOC** -,427,1966
oral
human 		lowest published toxic dose: 9 mg/kg/60 day Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 34ZIAG -,200,1969
oral
mouse 		lethal dose (50 percent kill): 176 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 5,605,1963
oral
rat 		lethal dose (50 percent kill): 20 mg/kg N/R WRPCA2 9,119,1970
subcutaneous
chicken 		lethal dose (50 percent kill): >200 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 5,605,1963
subcutaneous
rat 		lethal dose (50 percent kill): 95 mg/kg N/R JEENAI 52,20,1959
skin
rat 		lethal dose (50 percent kill): 63 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 5,605,1963
skin
rabbit 		lethal dose (50 percent kill): 85 mg/kg N/R PCOC** -,427,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 9,600 µg/kg/12 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 5,605,1963
oral
human 		lowest published toxic dose: 4.2 mg/kg/28 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 1,59,2001
oral
rat 		lowest published toxic dose: 70,980 µg/kg/13 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 5,605,1963


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,114,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 mg/m3, Skin, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIOXATHION-air 10 hour time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
Used for control of insects and mites on grapes, citrus, etc.
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-125,1978


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used for control of insects and mites on grapes, citrus, etc.

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

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