The Registry of Toxic Effects of Chemical Substances

Phosphorodithioic acid, O,O - dimethyl ester, S - ester with N - (mercaptomethyl) phthalimide

RTECS #: TE2275000

CAS #: 732-11-6

UPDATE: February 2005 MW: 317.33 MF: C11H12NO4PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. APPA
  2. Decemthion
  3. Decemthion P - 6
  4. O,O - Dimethyl S - (N - phthalimidomethyl) dithiophosphate
  5. O,O - Dimethyl 5 - (phthalimidomethyl) dithiophosphate
  6. O,O - Dimethyl S - phthalimidomethyl phosphorodithioate
  7. ENT 25,705
  8. Fosmet
  9. Ftalophos
  10. Imidan
  11. N - (Mercaptomethyl) phthalimide S - (O,O - dimethyl phosphorodithioate)
  12. Percolate
  13. Kemolate
  1. Phosphorodithioic acid, S - ( (1,3 - dihydro - 1,3 - dioxo - isoindol - 2 - yl) methyl) O,O - dimethyl ester
  2. Phosmet
  3. R 1504
  4. Smidan
  5. Stauffer R 1504
  6. Phtalofos
  7. Phthalimide, N - (mercaptomethyl) - , S - ester with O,O - dimethyl phosphorodithioate
  8. Phthalimido O,O - dimethyl phosphorodithioate
  9. Phthalimidomethyl O,O - dimethyl phosphorodithioate
  10. Phthalophos
  11. PMP
  12. Prolate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
mouse 		20 mg/kg SOGEBZ 11,1534,1975
DNA damage human fibroblast 63,466 µg/L EMMUEG 20,73,1992
mutation in microorganisms Salmonella typhimurium 500 µg/plate (+/-enzymatic activation step) MUREAV 302,153,1993
mutation in microorganisms Saccharomyes cerevisiae 1 pph (-enzymatic activation step) MUREAV 302,153,1993
gene conversion and mitotic recombination Saccharomyes cerevisiae 25,000 ppm MUREAV 302,153,1993
mutation in mammalian somatic cells hamster lung 175 mg/L EMMUEG 20,73,1992
morphological transform hamster embryo 7,933 µg/L EMMUEG 20,73,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 49,600 µg/kg (1-8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		AXVMAW 34,791,1980
oral
mouse 		lowest published toxic dose: 6,200 µg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) AXVMAW 34,791,1980
oral
mouse 		lowest published toxic dose: 124 mg/kg (1-8 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) AXVMAW 34,791,1980
oral
rat 		lowest published toxic dose: 30 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** PB80-159627
oral
rat 		lowest published toxic dose: 30 mg/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system EVHPAZ 13,121,1976
oral
rat 		lowest published toxic dose: 16,500 µg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		EVHPAZ 13,121,1976
oral
rat 		lowest published toxic dose: 100 mg/kg (1-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Stillbirth 		VETNAL 56(1),62,1980
oral
rat 		lowest published toxic dose: 6 mg/kg (1-20 day pregnant) Reproductive: Maternal effects: Parturition VETNAL 56(1),62,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): 65 mg/m3/4 hour N/R 85GMAT -,59,1982
inhalation
human 		lowest published toxic concentration: 2 mg/m3/8 hour Olfaction: Other olfaction effects

Eye: Lacrimation

Behavioral: Somnolence (general depressed activity) 		HYSAAV 34(1-3),192,1969
inhalation
rat 		lethal concentration (50 percent kill): 54 mg/m3/4 hour N/R 85GMAT -,59,1982
oral
wild bird 		lethal dose (50 percent kill): 18 mg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 707 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 6,147,1964
oral
duck 		lethal dose (50 percent kill): 1,830 mg/kg N/R DOEAAH 35,25,1979
oral
guinea pig 		lethal dose (50 percent kill): 200 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		HYSAAV 34(1-3),192,1969
oral
human 		lowest published lethal dose: 50 mg/kg N/R SPEADM 74-1,-,1974
oral
mouse 		lethal dose (50 percent kill): 26 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		HYSAAV 34(1-3),192,1969
oral
rat 		lethal dose (50 percent kill): 92,500 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 34(2),30,1969
skin
rat 		lethal dose (50 percent kill): 1,326 mg/kg N/R 85GMAT -,59,1982
skin
rabbit 		lethal dose (50 percent kill): >3,160 mg/kg N/R 85JFAN A325,1983
unreported route
cat 		lethal dose (50 percent kill): 78 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 35(12),94,1970
unreported route
guinea pig 		lethal dose (50 percent kill): 210 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 35(12),94,1970
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 40 mg/kg N/R 30ZDA9 -,370,1971
unreported route
mouse 		lethal dose (50 percent kill): 37,500 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 35(12),94,1970
unreported route
rat 		lethal dose (50 percent kill): 132 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 35(12),94,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 18 mg/m3/35 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GISAAA 34(2),30,1969
inhalation
rat 		lowest published toxic concentration: 16 mg/m3/35 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 34(2),30,1969
skin
rabbit 		lowest published toxic dose: 4,500 mg/kg/21 day- intermittent Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0545680
unreported route
cat 		lowest published toxic dose: 273 mg/kg/30 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 35(12),94,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
TOLED5 1422072003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,142,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1561;
Number of Industries 1;
Total Number of Facilities 230;
Number of Occupations 1;
Total Number of Employees Exposed 1,838;
Total Number of Female Employees Exposed 1,608


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9097
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-

Used as an organophosphorus insecticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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