The Registry of Toxic Effects of Chemical Substances

Phosphorodithioic acid, O,O - dimethyl ester, S - ester with 3 - (mercaptomethyl) - 1,2,3 - benzotriazin - 4 (3H) - one

RTECS #: TE1925000

CAS #: 86-50-0

UPDATE: November 2004 MW: 317.34 MF: C10H12N3O3PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2,3 - Benzotriazin - 4 (3H) - one, 3 - (mercaptomethyl) - , O,O - dimethyl phosphorodithioate
  2. 3 - (Mercaptomethyl) - 1,2,3 - benzotriazin - 4 (3H) - one O,O - dimethyl phosphorodithioate S - ester
  3. Azinfos - methyl (Dutch)
  4. Azinphos methyl
  5. Azinphos - methyl
  6. Azinphos - methyl (ACGIH:OSHA)
  7. Azinphos - metile (Italian)
  8. Azinphosmethyl
  9. BAY 17147
  10. BAY 9027
  11. Bayer 17147
  12. Bayer 9027
  13. Benzotriazine derivative of a methyl dithiophosphate
  14. Benzotriazinedithiophosphoric acid dimethoxy ester
  15. Carfene
  16. Cotneon
  17. Cotnion methyl
  18. Crysthion 2L
  19. Crysthyon
  20. Dimethyldithiophosphoric acid N - methylbenzazimide ester
  21. ENT 23,233
  22. Gusathion
  23. Gusathion 25
  24. Gusathion M
  1. Gusathion methyl
  2. Gusathion - 20
  3. Guthion (DOT:OSHA)
  4. Methyl guthion
  5. Methylazinphos
  6. Methylgusathion
  7. Metiltriazotion
  8. N - Methylbenzazimide, dimethyldithiophosphoric acid ester
  9. NCI - C00066
  10. O,O - Dimethyl S - (3,4 - dihydro - 4 - keto - 1,2,3 - benzotriazinyl - 3 - methyl) dithiophosphate
  11. O,O - Dimethyl S - (4 - oxo - 1,2,3 - benzotriazino (3) - methyl) thiothionophosphate
  12. O,O - Dimethyl S - (4 - oxo - 3H - 1,2,3 - benzotriazine - 3 - methyl) phosphorodithioate
  13. O,O - Dimethyl S - (4 - oxobenzotriazino - 3 - methyl) phosphorodithioate
  14. O,O - Dimethyl S - 4 - oxo - 1,2,3 - benzotriazin - 3 (4H) - ylmethyl phosphorodithioate
  15. O,O - Dimethyl - S - ( (4 - oxo - 3H - 1,2,3 - benzotriazin - 3 - yl) - methyl) - dithiofosfaat (Dutch)
  16. O,O - Dimethyl - S - ( (4 - oxo - 3H - 1,2,3 - benzotriazin - 3 - yl) - methyl) - dithiophosphat (German)
  17. O,O - Dimethyl - S - (1,2,3 - benzotriazinyl - 4 - keto) methyl phosphorodithioate
  18. O,O - Dimethyl - S - (4 - oxobenzotriazin - 3 - methyl) - dithiophosphat (German)
  19. O,O - Dimethyl - S - (benzaziminomethyl) dithiophosphate
  20. O,O - Dimetil - S - ( (4 - oxo - 3H - 1,2,3 - benzotriazin - 3 - il) - metil) - ditiofosfato (Italian)
  21. R 1582
  22. S - (3,4 - Dihydro - 4 - oxo - 1,2,3 - benzotriazin - 3 - ylmethyl) O,O - dimethyl phosphorodithioate
  23. S - (3,4 - Dihydro - 4 - oxo - benzo (alpha) (1,2,3) triazin - 3 - ylmethyl) O,O - dimethyl phosphorodithioate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 60 mg/L/18 hour- continuous CHROAU 49,77,1974
cytogenetic analysis human lung 120 mg/L CNJGA8 18,665,1976
cytogenetic analysis human other cell types 140 mg/L CNJGA8 18,665,1976
unscheduled DNA synthesis human fibroblast 10 µmol/L NTIS** PB268-647
mutation in microorganisms Salmonella typhimurium 7,500 µg/plate (-enzymatic activation step) ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms Saccharomyes cerevisiae 10 gm/L (-enzymatic activation step) MUREAV 321,203,1994
mutation in microorganisms Schizosaccharomyces pombe 25 mmol/L (+/-enzymatic activation step) MUREAV 117,139,1983
micronucleus test human lymphocyte 60 µg/L MUREAV 388,27,1997
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 gm/L MUREAV 321,203,1994
mutation in mammalian somatic cells mouse lymphocyte 10 mg/L NTIS** PB84-138973
other mutation test systems hamster ovary 80 mg/L CHROAU 49,77,1974
other mutation test systems human fibroblast 120 mg/L CNJGA8 18,665,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 16 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TCMUD8 5,3,1985
oral
mouse 		lowest published toxic dose: 20 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TCMUD8 5,3,1985
oral
rat 		lowest published toxic dose: 190 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		ARTODN 43,177,1980
oral
rat 		lowest published toxic dose: 12,500 µg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system ARTODN 43,177,1980
oral
rat 		lowest published toxic dose: 85 mg/kg (6-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** PB288-457
oral
rat 		lowest published toxic dose: 20 mg/kg (6-15 day pregnant) Reproductive: Other effects on female TIHEEC 14,869,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5,110 mg/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Endocrine: Thyroid tumors 		NCITR* NCI-TR-69,1978
oral
rat 		toxic dose : 121 gm/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		JEPTDQ 1(6),829,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 69 mg/m3/1 hour N/R NTIS** PB277-077
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 40 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 119,208,1957
intraperitoneal
mouse 		lethal dose (50 percent kill): 4 mg/kg N/R PSEBAA 129,699,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 4,900 µg/kg N/R PSEBAA 114,509,1963
intravenous
rat 		lethal dose (50 percent kill): 7,500 µg/kg N/R NTIS** PB277-077
oral
wild bird 		lethal dose (50 percent kill): 8,500 µg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 277 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 11,49,1967
oral
duck 		lethal dose (50 percent kill): 136 mg/kg N/R DOEAAH 35,25,1979
oral
dog 		lethal dose (50 percent kill): 10 mg/kg N/R PEMNDP 9,46,1991
oral
guinea pig 		lethal dose (50 percent kill): 80 mg/kg N/R PCOC** -,570,1966
oral
mouse 		lethal dose (50 percent kill): 8,600 µg/kg N/R PESTD5 17,292,1976
oral
rat 		lethal dose (50 percent kill): 7 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JPPMAB 13,435,1961
skin
guinea pig 		lethal dose (50 percent kill): >280 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea 		KUMJAX 12,313,1959
skin
mouse 		lethal dose (50 percent kill): 65 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea 		KUMJAX 12,313,1959
skin
rat 		lethal dose (50 percent kill): 88 mg/kg N/R 85JCAE -,1182,1986
unreported route
quail 		lethal dose (50 percent kill): 32,200 µg/kg N/R FMCHA2 -,C32,1991
unreported route
rat 		lethal dose (50 percent kill): 15 mg/kg N/R 30ZDA9 -,371,1971
unreported route
rat 		lowest published toxic dose: 1.5 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,309,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 4,720 µg/m3/6 hour/12 week- intermittent Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ARTODN 35,83,1976
intraperitoneal
rat 		lowest published toxic dose: 120 mg/kg/60 day- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 119,208,1957
oral
dog 		lowest published toxic dose: 3,094 mg/kg/2 year- continuous Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 24,405,1973
oral
mouse 		lowest published toxic dose: 174 mg/kg/9 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BECTA6 60,194,1998
oral
rat 		lowest published toxic dose: 3,650 mg/kg/2 year- continuous Behavioral: Convulsions or effect on seizure threshold

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 24,405,1973
oral
rat 		lowest published toxic dose: 82,810 µg/kg/13 week- continuous Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		FAATDF 35,101,1997
oral
rat 		lowest published toxic dose: 2,184 mg/kg/80 week- continuous Endocrine: Thyroid tumors HBPTO* 1,814,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 ( intermittent,V) (skin, sen) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
RREVAH 51,123,1974
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,87,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 (skin) DTLVS* 3,20,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.02 mg/m3, short term exposure limit 0.06 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.2 mg/m3, Skin (total dust), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO AZINPHOS-METHYL-air 10 hour time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 35750;
Number of Industries 3;
Total Number of Facilities 298;
Number of Occupations 4;
Total Number of Employees Exposed 595


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as pesticide for a wide variety of insects
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat NCITR* NCI-TR-69,1978
NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* NCI-TR-69,1978


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939-
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
KUMJAX Kumamoto Medical Journal. (Kumamoto Univ. Medical School, 2-2-1 Honjo, Kumamoto 860, Japan) V.1- 1938-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as pesticide for a wide variety of insects

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 54182-73-9
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