The Registry of Toxic Effects of Chemical Substances
Phosphorodithioic acid, O,O - dimethyl ester, S - ester with 2 - mercapto - N - methylacetamide |
UPDATE: May 2005 | MW: 229.27 | MF: C5H12NO3PS2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
body fluid assay |
rat
Salmonella typhimurium | 50,600 礸/kg | IJEBA6 24,305,1986 |
cytogenetic analysis |
intraperitoneal hamster | 16 mg/kg | ARTODN 58,152,1986 |
cytogenetic analysis | hamster lung | 390 mg/L | GMCRDC 27,95,1981 |
cytogenetic analysis | human lymphocyte | 44 祄ol/L | SOGEBZ 10,1580,1974 |
cytogenetic analysis |
intraperitoneal mouse | 60 mg/kg | MUREAV 97,207,1982 |
cytogenetic analysis |
parenteral mouse | 50 mg/kg | CUSCAM 44,859,1975 |
cytogenetic analysis |
oral mouse | 1,376 礸/kg/10 day- continuous | MUREAV 299,29,1993 |
cytogenetic analysis | other fish lymphocyte | 1 mmol/L | ENMUDM 8,555,1986 |
cytogenetic analysis |
intraperitoneal rat | 19 mg/kg | NULSAK 33,14,1990 |
DNA repair | other microorganisms | 10 mg/plate | BIZNAT 95,463,1976 |
unscheduled DNA synthesis | human fibroblast | 100 祄ol/L | MUREAV 42,161,1977 |
unscheduled DNA synthesis |
intraperitoneal mouse | 80 mg/kg | APTOA6 55,104,1984 |
host-mediated assay |
mouse
Salmonella typhimurium | 465 mg/kg/3 day- continuous | BECTA6 25,277,1980 |
mutation in microorganisms | Escherichia coli | 1 mmol/L/4 hour (-enzymatic activation step) | MUREAV 20,7,1973 |
mutation in microorganisms | other microorganisms | 100 mg/L (-enzymatic activation step) | CYGEDX 15(3),64,1981 |
mutation in microorganisms | Salmonella typhimurium | 5 礸/plate (+enzymatic activation step) | IJEBA6 24,305,1986 |
mutation in microorganisms | Salmonella typhimurium | 500 礸/plate (-enzymatic activation step) | JTEHD6 16,403,1985 |
mutation in microorganisms | Saccharomyes cerevisiae | 10 gm/L (+/-enzymatic activation step) | MUREAV 321,203,1994 |
micronucleus test | human lymphocyte | 10 mg/L | MUREAV 388,27,1997 |
micronucleus test |
oral mouse | 103 mg/kg/24 hour | BECTA6 25,277,1980 |
micronucleus test |
intraperitoneal rat | 47,500 礸/kg | NULSAK 33,14,1990 |
gene conversion and mitotic recombination | Saccharomyes cerevisiae | 66 mmol/L/27 hour | IARCCD 10,161,1974 |
other mutation test systems |
oral mouse | 1,376 礸/kg/10 day- continuous | MUREAV 299,29,1993 |
sister chromatid exchange | hamster lung | 20 mg/L | ENMUDM 4,621,1982 |
sister chromatid exchange | human lymphocyte | 2 mg/L | MUREAV 102,89,1982 |
sister chromatid exchange | human embryo | 229 mg/L | SNSHBT (20),574,1980 |
sister chromatid exchange | other fish lymphocyte | 300 祄ol/L | ENMUDM 8,555,1986 |
sex chromosome loss and nondisjunction |
parenteral Drosophila melanogaster | 10 ppm | MUREAV 172,237,1986 |
sex chromosome loss and nondisjunction |
oral Drosophila melanogaster | 75 ppb/96 hour | MUREAV 206,351,1988 |
specific locus test |
oral Drosophila melanogaster | 75 ppb/96 hour | MUREAV 206,351,1988 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal mouse | lowest published toxic dose: 40 mg/kg (1 day pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | BIRUAA 13,238,1975 |
oral cat | lowest published toxic dose: 108 mg/kg (14-22 day pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | JEPTDQ 2(6),1283,1979 |
oral mouse | lowest published toxic dose: 1,050 mg/kg (multigenerations) |
Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) | TXAPA9 26,29,1973 |
oral mouse | lowest published toxic dose: 220 mg/kg (6-16 day pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | JPFCD2 20,373,1985 |
oral mouse | lowest published toxic dose: 440 mg/kg (6-16 day pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | JPFCD2 20,373,1985 |
oral rat | lowest published toxic dose: 120 mg/kg (6-15 day pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | BECTA6 22,522,1979 |
oral rat | lowest published toxic dose: 113 mg/kg (6-20 day pregnant) |
Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects to embryo or fetus | IJEBA6 34,329,1996 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intramuscular rat | lowest published toxic dose: 176 mg/kg/6 week- intermittent |
Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Tumors | ARGEAR 41,311,1973 |
oral rat | lowest published toxic dose: 256 mg/kg/4 week- intermittent |
Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Tumors | ARGEAR 41,311,1973 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal guinea pig | lethal dose (10 percent kill): 390 mg/kg | N/R | TXAPA9 8,259,1966 |
intraperitoneal hamster | lethal dose (50 percent kill): 160 mg/kg | N/R | ARTODN 58,152,1986 |
intraperitoneal mouse | lethal dose (50 percent kill): 45 mg/kg |
Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | BJIMAG 21,52,1964 |
intraperitoneal mouse | lowest published toxic dose: 50 mg/kg | Behavioral: Change in motor activity (specific assay) | BECTA6 70,138,2003 |
intraperitoneal rat | lethal dose (50 percent kill): 100 mg/kg |
Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | BJIMAG 21,52,1964 |
intravenous rat | lethal dose (50 percent kill): 450 mg/kg |
Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | BJIMAG 21,52,1964 |
oral wild bird | lethal dose (50 percent kill): 6,600 礸/kg | N/R | TXAPA9 21,315,1972 |
oral cat | lethal dose (50 percent kill): 100 mg/kg | Behavioral: Excitement | GISAAA 28(3),21,1963 |
oral chicken | lethal dose (50 percent kill): 25 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JAFCAU 11,91,1963 |
oral duck | lethal dose (50 percent kill): 42 mg/kg | N/R | DOEAAH 35,25,1979 |
oral dog | lethal dose (50 percent kill): 400 mg/kg | N/R | SPEADM 78-1,31,1978 |
oral guinea pig | lethal dose (50 percent kill): 350 mg/kg | N/R | PCOC** -,395,1966 |
oral hamster | lethal dose (50 percent kill): 200 mg/kg |
Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | BJIMAG 21,52,1964 |
oral human | lethal dose (50 percent kill): 30 mg/kg | N/R | GUCHAZ 6,209,1973 |
oral man | lowest published toxic dose: 286 mg/kg |
Peripheral Nerve and Sensation: Fasciculations Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea | ICMED9 12,110,1986 |
oral man | lowest published toxic dose: 300 mg/kg |
Behavioral: Coma Cardiac: Pulse rate decreased with fall in BP Vascular: BP lowering not characterized in autonomic section | JTCTDW 24,69,1986 |
oral man | lowest published toxic dose: 357 mg/kg |
Brain and Coverings: Other degenerative changes Cardiac: Cardiomyopathy including infarction Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | JTCTDW 32,61,1994 |
oral mouse | lethal dose (50 percent kill): 60 mg/kg |
Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | BJIMAG 21,52,1964 |
oral quail | lethal dose (50 percent kill): 25 mg/kg | N/R | JAFCAU 29,772,1981 |
oral rat | lethal dose (50 percent kill): 60 mg/kg | N/R | YKYUA6 30,623,1979 |
oral rabbit | lethal dose (50 percent kill): 300 mg/kg | N/R | SPEADM 78-1,31,1978 |
subcutaneous hamster | lethal dose (50 percent kill): 60 mg/kg |
Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | BJIMAG 21,52,1964 |
subcutaneous mouse | lethal dose (50 percent kill): 60 mg/kg |
Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | BJIMAG 21,52,1964 |
subcutaneous rat | lethal dose (50 percent kill): 350 mg/kg |
Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | BJIMAG 21,52,1964 |
skin guinea pig | lethal dose (50 percent kill): 965 mg/kg | N/R | TXAPA9 3,210,1961 |
skin mouse | lethal dose (50 percent kill): 1 gm/kg | N/R | GISAAA 33(6),6,1968 |
skin rat | lethal dose (50 percent kill): 353 mg/kg | N/R | BJIMAG 26,59,1969 |
skin rabbit | lethal dose (50 percent kill): 1 gm/kg | Behavioral: Excitement | GISAAA 28(3),21,1963 |
unreported route mouse | lethal dose (50 percent kill): 158 mg/kg | N/R | RISHDJ 23,101,1983 |
unreported route rat | lethal dose (50 percent kill): 215 mg/kg | N/R | YKYUA6 28,225,1977 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation guinea pig | lowest published toxic concentration: 4,500 礸/m3/8 hour/13 week- intermittent |
Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 33(6),6,1968 |
inhalation rat | lowest published toxic concentration: 4,500 礸/m3/13 week- intermittent |
Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 33(6),6,1968 |
inhalation rat | lowest published toxic concentration: 257 礸/m3/24 hour/15 week- intermittent |
Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 41(9),7,1976 |
intraperitoneal mouse | lowest published toxic dose: 60 mg/kg/30 day- intermittent |
Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | TOLED5 91,1,1997 |
intraperitoneal mouse | lowest published toxic dose: 120 mg/kg/30 day- intermittent |
Endocrine: Evidence of thyroid hyperfunction Biochemical: Metabolism (intermediary): Other | TOLED5 91,1,1997 |
oral chicken | lowest published toxic dose: 56 mg/kg/4 week- intermittent |
Liver: Other changes Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | BECTA6 57,335,1996 |
oral dog | lowest published toxic dose: 3,937 mg/kg/90 day- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 3,210,1961 |
oral rat | lowest published toxic dose: 630 mg/kg/28 day- intermittent |
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | IJEBA6 30,394,1992 |
oral rat | lowest published toxic dose: 1,092 mg/kg/52 week- continuous |
Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | BJIMAG 21,52,1964 |
oral rat | lowest published toxic dose: 300 mg/kg/6 week- intermittent |
Brain and Coverings: Changes in surface EEG Peripheral Nerve and Sensation: Recording from peripheral motor nerve Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 10,429,1988 |
oral rat | lowest published toxic dose: 3,330 mg/kg/90 day- continuous |
Eye: Other eye effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 3,210,1961 |
oral rat | lowest published toxic dose: 3,852 mg/kg/26 week- intermittent |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli | JDGRAX 21,225,1994 |
oral rat | lowest published toxic dose: 500 mg/kg/5 day- intermittent | Skin: After systemic exposure: Dermatitis, other | TOXID9 54,334,2000 |
oral rat | lowest published toxic dose: 10,752 mg/kg/80 week- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | ENVRAL 34,193,1984 |
oral rat | lowest published toxic dose: 5,208 mg/kg/80 week- continuous |
Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Blood: Leukemia Reproductive: Paternal effects: Testes, epididymis, sperm duct | ENVRAL 34,193,1984 |
oral rat | lowest published toxic dose: 5,376 mg/kg/80 week- continuous | Blood: Leukemia | ENVRAL 34,193,1984 |
oral rat | lowest published toxic dose: 1,260 mg/kg/60 day- intermittent |
Gastrointestinal: Changes in structure or function of exocrine pancreas Endocrine: Hyperglycemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | TOLED5 133,161,2002 |
skin mouse | lowest published toxic dose: 3 pph/6 week- intermittent |
Skin and Appendages: Other: Breast Tumorigenic: Tumor types after systemic administration not seen spontaneously | ENVRAL 34,193,1984 |
skin mouse | lowest published toxic dose: 3 pph/6 week- intermittent | Blood: Leukemia | ENVRAL 34,193,1984 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
TOXICOLOGY REVIEW |
| AQMOAC #73-19,1973 |
TOXICOLOGY REVIEW |
| RREVAH 46,1,1973 |
TOXICOLOGY REVIEW |
| MZUZA8 (8),90,1973 |
TOXICOLOGY REVIEW |
| DTTIAF 80,485,1973 |
TOXICOLOGY REVIEW |
| RREVAH 63,1,1976 |
TOXICOLOGY REVIEW |
| ENVRAL 34,193,1984 |
TOXICOLOGY REVIEW |
| NULSAK 28,243,1985 |
TOXICOLOGY REVIEW |
| TOLED5 128,45,2002 |
TOXICOLOGY REVIEW |
| MUREAV 562,77,2004 |
TOXICOLOGY REVIEW |
| MUREAV 567,109,2004 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 | PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF | PESTICIDES: Supported | RBREV* -,113,1998 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 84534; Number of Industries 2; Total Number of Facilities 30; Number of Occupations 2; Total Number of Employees Exposed 90 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 84534; Number of Industries 1; Total Number of Facilities 54; Number of Occupations 1; Total Number of Employees Exposed 1,665; Total Number of Female Employees Exposed 107 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion | |
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat | |
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal | |
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as an insecticide | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat | NCITR* NCI-TR-4,1977 |
REFERENCES: | |
CODEN |
REFERENCE |
APTOA6 | Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH |
AQMOAC | Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. |
ARGEAR | Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- |
ARTODN | Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- |
BECTA6 | Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- |
BIRUAA | Biologische Rundschau. (VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.) V.1- 1963- |
BIZNAT | Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881- |
BJIMAG | British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- |
CUSCAM | Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- |
CYGEDX | Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- |
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DTTIAF | Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. |
ENMUDM | Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. |
ENVRAL | Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- |
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GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
GMCRDC | Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- |
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JPFCD2 | Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976- |
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PCOC** | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) |
RBREV* | Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 |
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YKYUA6 | Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- |