The Registry of Toxic Effects of Chemical Substances
Phosphorodithioic acid, O,O - diethyl S - (2 - (ethylthio) ethyl) ester |
UPDATE: November 2004 | MW: 274.42 | MF: C8H19O2PS3 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
unscheduled DNA synthesis | human fibroblast | 1 gm/L | NTIS** PB80-133226 |
mutation in microorganisms | Escherichia coli | 5,720 µg/plate (-enzymatic activation step) | MUREAV 28,405,1975 |
mutation in microorganisms | Salmonella typhimurium | 5,720 µg/plate (+enzymatic activation step) | MUREAV 28,405,1975 |
mutation in microorganisms | Salmonella typhimurium | 5 mg/plate (-enzymatic activation step) | MUREAV 116,185,1983 |
mutation in mammalian somatic cells | mouse lymphocyte | 40 mg/L | NTIS** PB84-138973 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation cat | lowest published lethal concentration: 10 mg/m3/4 hour |
Behavioral: Tremor Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea | GTPZAB 4(9),21,1960 |
inhalation rat | lethal concentration (50 percent kill): 200 mg/m3 | N/R | 85GYAV -,25,1971 |
intraperitoneal guinea pig | lethal dose (50 percent kill): 7 mg/kg |
Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased | AMIHAB 17,192,1958 |
intraperitoneal mouse | lethal dose (50 percent kill): 5,500 µg/kg |
Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased | AMIHAB 17,192,1958 |
intraperitoneal rat | lethal dose (50 percent kill): 2 mg/kg |
Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased | AMIHAB 17,192,1958 |
intravenous rat | lethal dose (50 percent kill): 5,500 µg/kg |
Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | 13ZGAF -,206,1962 |
oral wild bird | lethal dose (50 percent kill): 2,400 µg/kg | N/R | TXAPA9 21,315,1972 |
oral duck | lethal dose (50 percent kill): 6,500 µg/kg | N/R | DOEAAH 35,25,1979 |
oral dog | lethal dose (50 percent kill): 5 mg/kg | N/R | PEMNDP 9,318,1991 |
oral guinea pig | lethal dose (50 percent kill): 10,800 µg/kg |
Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume increased | AMIHAB 17,192,1958 |
oral mouse | lethal dose (50 percent kill): 4,800 µg/kg |
Behavioral: Tremor Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea | GTPZAB 4(9),21,1960 |
oral quail | lethal dose (50 percent kill): 12 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | EESADV 8,551,1984 |
oral rat | lethal dose (50 percent kill): 2,600 µg/kg | N/R | YKYUA6 37,717,1986 |
oral woman | lowest published toxic dose: 800 µg/kg |
Behavioral: Hallucinations, distorted perceptions Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes | JJTOEX 8,69,1995 |
skin mouse | lethal dose (50 percent kill): 15,600 µg/kg | N/R | YKYUA6 37,717,1986 |
skin rat | lethal dose (50 percent kill): 6 mg/kg | N/R | TXAPA9 14,515,1969 |
skin rabbit | lowest published lethal dose: 5 mg/kg | N/R | GTPZAB 2(5),7,1958 |
unreported route chicken | lethal dose (50 percent kill): 28 mg/kg | N/R | FMCHA2 -,C113,1991 |
unreported route mouse | lethal dose (50 percent kill): 4,600 µg/kg | N/R | GTPZAB 7(5),38,1963 |
unreported route rat | lethal dose (50 percent kill): 2,500 µg/kg | N/R | 30ZDA9 -,369,1971 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal mouse | lowest published toxic dose: 140 mg/kg/14 day- intermittent |
Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 65,457,1982 |
intraperitoneal rat | lowest published toxic dose: 60 mg/kg/60 day- intermittent |
Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 17,192,1958 |
intraperitoneal rat | lowest published toxic dose: 60 mg/kg/30 day- intermittent |
Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | FAATDF 20,163,1993 |
intraperitoneal rat | lowest published toxic dose: 28 mg/kg/14 day- intermittent |
Brain and Coverings: Other degenerative changes Behavioral: Alteration of operant conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOLED5 40,47,1988 |
oral dog | lowest published toxic dose: 36,500 µg/kg/1 year- intermittent |
Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 42,154,1998 |
oral rat | lowest published toxic dose: 5,460 µg/kg/13 week- continuous |
Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | FAATDF 35,101,1997 |
oral rat | lowest published toxic dose: 352 mg/kg/20 week- continuous |
Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Other | ANYAA9 160,378,1969 |
oral rat | lowest published toxic dose: 61 mg/kg/9 week- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | GTPZAB 4(9),21,1960 |
unreported route rat | lowest published toxic dose: 28 mg/kg/14 day- intermittent | Brain and Coverings: Other degenerative changes | HBPTO* 2,1026,2001 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 0.05 mg/m3 (skin) ( intermittent,V) | DTLVS* TLV/BEI,2003 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Not Classifiable as a Human Carcinogen | DTLVS* TLV/BEI,2003 |
TOXICOLOGY REVIEW |
| AQMOAC #73-19,1973 |
TOXICOLOGY REVIEW |
| MZUZA8 (8),90,1973 |
TOXICOLOGY REVIEW |
| DTTIAF 80,485,1973 |
TOXICOLOGY REVIEW |
| RREVAH 63,1,1976 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 | PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF | PESTICIDES: Supported | RBREV* -,115,1998 |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 0.1 mg/m3, JAN1993 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 0.1 mg/m3, JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 0.1 mg/m3, Skin, JAN1999 | |
Occupational Exposure Limit - FRANCE | VME 0.1 mg/m3, JAN1999 | |
Occupational Exposure Limit - NORWAY | time-weighted average 0.1 mg/m3, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 0.1 mg/m3, JAN1999 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, SEP2000 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 0.1 mg/m3, Skin, 2003 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; Not Classifiable as a Human Carcinogen | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DISULFOTON-air | 10 hour time-weighted average 0.1 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: T0249; Number of Industries 2; Total Number of Facilities 92; Number of Occupations 2; Total Number of Employees Exposed 165 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264347) | |
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast | |
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test | |
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal; TRP reversion | |
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis | |
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9 | |
Used as systemic insecticide and acaricide | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600 |
REFERENCES: | |
CODEN |
REFERENCE |
13ZGAF | "Gigiena i Toksikologiya Novykh Pestitsidov i Klinika Otravlenii, Doklady Vsesoyuznoi Konferentsii, 2nd, 1962," Hygiene and Toxicology of New Pesticides and Clinical Aspects of Poisoning, Medved, L.I., et al., eds., Komiteta Po Izucheniiu i Reglamenta-tsii Indokhimikatov Glavnoi Gosudarstvennoi Sanitarnoi Inspectsii USSR, 1962 |
30ZDA9 | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 |
85GYAV | "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971 |
AMIHAB | AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. |
ANYAA9 | Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- |
AQMOAC | Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. |
DOEAAH | Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945- |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
DTTIAF | Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. |
EESADV | Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- |
FAATDF | Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 |
FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
FMCHA2 | Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
HBPTO* | Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 |
JJTOEX | Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
MZUZA8 | Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
PEMNDP | Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- |
RBREV* | Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 |
RREVAH | Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- |
TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |
TOXID9 | Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |
YKYUA6 | Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- |