The Registry of Toxic Effects of Chemical Substances

Phosphorodithioic acid, O,O - diethyl S - (2 - (ethylthio) ethyl) ester

RTECS #: TD9275000

CAS #: 298-04-4

UPDATE: November 2004 MW: 274.42 MF: C8H19O2PS3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. BAY 19639
  2. Bayer 19639
  3. Di - syston
  4. Disulfoton
  5. Disulfoton (ACGIH)
  6. Dithiodemeton
  7. Dithiophosphate de O,O - diethyle et de S - (2 - ethylthio - ethyle) (French)
  8. Dithiosystox
  9. Dution
  10. ENT 23,437
  11. Ekatin TD
  12. Ethyl thiometon
  13. Ethylthiometon B
  14. Frumin AL
  15. Frumin G
  16. Glebofos
  17. M - 74
  18. M - 74 (Pesticide)
  1. O,O - Diaethyl - S - (2 - aethylthio - aethyl) - dithiophosphat (German)
  2. O,O - Diaethyl - S - (3 - thia - pentyl) - dithiophosphat (German)
  3. O,O - Diethyl 2 - ethylthioethyl phosphorodithioate
  4. O,O - Diethyl S - (2 - eththioethyl) phosphorodithioate
  5. O,O - Diethyl S - (2 - eththioethyl) thiothionophosphate
  6. O,O - Diethyl S - (2 - ethylmercaptoethyl) dithiophosphate
  7. O,O - Diethyl S - 2 - (ethylthio) ethyl phosphorodithioate
  8. O,O - Diethyl - S - (2 - ethylthio - ethyl) - dithiofosfaat (Dutch)
  9. O,O - Dietil - S - (2 - etiltio - etil) - ditiofosfato (Italian)
  10. O,O - Ethyl S - 2 (ethylthio) ethyl phosphorodithioate
  11. Phosphorodithionic acid, S - 2 - (ethylthio) ethyl - O,O - diethyl ester
  12. RCRA waste number P039
  13. S - (2 - (Ethylthio) ethyl) phosphorothionate
  14. S - 2 - (Ethylthio) ethyl O,O - diethyl ester of phosphorodithioic acid
  15. Solvirex
  16. Thiodemeton
  17. Vuagt 1 - 4
  18. Vuagt 1964


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis human fibroblast 1 gm/L NTIS** PB80-133226
mutation in microorganisms Escherichia coli 5,720 µg/plate (-enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Salmonella typhimurium 5,720 µg/plate (+enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Salmonella typhimurium 5 mg/plate (-enzymatic activation step) MUREAV 116,185,1983
mutation in mammalian somatic cells mouse lymphocyte 40 mg/L NTIS** PB84-138973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 10 mg/m3/4 hour Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		GTPZAB 4(9),21,1960
inhalation
rat 		lethal concentration (50 percent kill): 200 mg/m3 N/R 85GYAV -,25,1971
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 7 mg/kg Peripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased 		AMIHAB 17,192,1958
intraperitoneal
mouse 		lethal dose (50 percent kill): 5,500 µg/kg Peripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased 		AMIHAB 17,192,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 2 mg/kg Peripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased 		AMIHAB 17,192,1958
intravenous
rat 		lethal dose (50 percent kill): 5,500 µg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		13ZGAF -,206,1962
oral
wild bird 		lethal dose (50 percent kill): 2,400 µg/kg N/R TXAPA9 21,315,1972
oral
duck 		lethal dose (50 percent kill): 6,500 µg/kg N/R DOEAAH 35,25,1979
oral
dog 		lethal dose (50 percent kill): 5 mg/kg N/R PEMNDP 9,318,1991
oral
guinea pig 		lethal dose (50 percent kill): 10,800 µg/kg Peripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased 		AMIHAB 17,192,1958
oral
mouse 		lethal dose (50 percent kill): 4,800 µg/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		GTPZAB 4(9),21,1960
oral
quail 		lethal dose (50 percent kill): 12 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		EESADV 8,551,1984
oral
rat 		lethal dose (50 percent kill): 2,600 µg/kg N/R YKYUA6 37,717,1986
oral
woman 		lowest published toxic dose: 800 µg/kg Behavioral: Hallucinations, distorted perceptions

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		JJTOEX 8,69,1995
skin
mouse 		lethal dose (50 percent kill): 15,600 µg/kg N/R YKYUA6 37,717,1986
skin
rat 		lethal dose (50 percent kill): 6 mg/kg N/R TXAPA9 14,515,1969
skin
rabbit 		lowest published lethal dose: 5 mg/kg N/R GTPZAB 2(5),7,1958
unreported route
chicken 		lethal dose (50 percent kill): 28 mg/kg N/R FMCHA2 -,C113,1991
unreported route
mouse 		lethal dose (50 percent kill): 4,600 µg/kg N/R GTPZAB 7(5),38,1963
unreported route
rat 		lethal dose (50 percent kill): 2,500 µg/kg N/R 30ZDA9 -,369,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 140 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 65,457,1982
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg/60 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 17,192,1958
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg/30 day- intermittent Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		FAATDF 20,163,1993
intraperitoneal
rat 		lowest published toxic dose: 28 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of operant conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOLED5 40,47,1988
oral
dog 		lowest published toxic dose: 36,500 µg/kg/1 year- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 42,154,1998
oral
rat 		lowest published toxic dose: 5,460 µg/kg/13 week- continuous Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		FAATDF 35,101,1997
oral
rat 		lowest published toxic dose: 352 mg/kg/20 week- continuous Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other 		ANYAA9 160,378,1969
oral
rat 		lowest published toxic dose: 61 mg/kg/9 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field GTPZAB 4(9),21,1960
unreported route
rat 		lowest published toxic dose: 28 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes HBPTO* 2,1026,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
MZUZA8 (8),90,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,115,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DISULFOTON-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0249;
Number of Industries 2;
Total Number of Facilities 92;
Number of Occupations 2;
Total Number of Employees Exposed 165


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264347)
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
Used as systemic insecticide and acaricide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


REFERENCES:

CODEN
REFERENCE
13ZGAF "Gigiena i Toksikologiya Novykh Pestitsidov i Klinika Otravlenii, Doklady Vsesoyuznoi Konferentsii, 2nd, 1962," Hygiene and Toxicology of New Pesticides and Clinical Aspects of Poisoning, Medved, L.I., et al., eds., Komiteta Po Izucheniiu i Reglamenta-tsii Indokhimikatov Glavnoi Gosudarstvennoi Sanitarnoi Inspectsii USSR, 1962
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as systemic insecticide and acaricide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

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