The Registry of Toxic Effects of Chemical Substances

Phosphorodithioic acid, S - ( ( (p - chlorophenyl) thio) methyl) O,O - diethyl ester

RTECS #: TD5250000

CAS #: 786-19-6

UPDATE: August 2003 MW: 342.87 MF: C11H16ClO2PS3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Akarithion
  2. S - ( (p - Chlorophenylthio) methyl) O,O - diethyl phosphorodithioate
  3. S - (4 - Chlorophenylthiomethyl) diethyl phosphorothiolothionate
  4. Dagadip
  5. O,O - Diaethyl - S - ( (4 - chlor - phenyl - thio) - methyl) dithiophosphat (German)
  6. O,O - Diethyl - S - ( (4 - chloor - fenyl - thio) - methyl) - dithiofosfaat (Dutch)
  7. O,O - Diethyl - S - p - chlorfenylthiomethylester kyseliny dithiofosforecne (Czech)
  8. O,O - Diethyl p - chlorophenylmercaptomethyl dithiophosphate
  9. O,O - Diethyl S - p - chlorophenylthiomethyl dithiophosphate
  10. O,O - Diethyl S - (4 - chlorophenylthiomethyl) dithiophosphate
  11. O,O - Diethyl S - (p - chlorophenylthiomethyl) phosphorodithioate
  12. O,O - Diethyl dithiophosphoric acid p - chlorophenylthiomethyl ester
  13. O,O - Dietil - S - ( (4 - cloro - fenil - tio) - metile) - ditiofosfato (Italian)
  14. Dithiophosphate de O,O - diethyle et de (4 - chloro - phenyl) thiomethyle (French)
  15. Endyl
  1. ENT 23,708
  2. Garrathion
  3. Oleoakarithion
  4. OMS 244
  5. Acarithion
  6. Carbofenothion (Dutch)
  7. Carbophenothion
  8. Karbofenothion (Czech)
  9. Lethox
  10. Nephocarp
  11. R - 1303
  12. Stauffer R - 1,303
  13. Trithion
  14. Trithion miticide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange human lymphocyte 20 µg/L MUREAV 102,89,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 27 mg/kg N/R PSEBAA 129,699,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 6 mg/kg N/R APCRAW 4,117,1961
oral
wild bird 		lethal dose (50 percent kill): 5,600 µg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 57,200 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		TXAPA9 11,,49,1967
oral
domestic animal 		lethal dose (50 percent kill): 14 mg/kg N/R EESADV 2,151,1978
oral
mouse 		lethal dose (50 percent kill): 218 mg/kg N/R ARSIM* 20,6,1966
oral
pigeon 		lethal dose (50 percent kill): 34,800 µg/kg N/R PSSCBG 6,245,1975
oral
quail 		lethal dose (50 percent kill): 56,800 µg/kg N/R PSSCBG 6,245,1975
oral
rat 		lethal dose (50 percent kill): 6,800 µg/kg N/R FMCHA2 -,C315,1991
oral
rabbit 		lethal dose (50 percent kill): 1,250 mg/kg N/R SPEADM 78-1,40,1978
subcutaneous
chicken 		lethal dose (50 percent kill): 640 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea 		BCPCA6 12,1377,1963
skin
rat 		lethal dose (50 percent kill): 27 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		TXAPA9 2,88,1960
skin
rabbit 		lethal dose (50 percent kill): 1,270 mg/kg N/R PCOC** -,200,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 630 mg/kg/7 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		PCBPBS 18,49,1982
oral
rat 		lowest published toxic dose: 7 mg/kg/4 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 3,500,1961


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,95,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a miticide and insecticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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