The Registry of Toxic Effects of Chemical Substances

Phosphorodithioic acid, S - ( (6 - chloro - 2 - oxo - 3 (2H) - benzoxazolyl) methyl) O,O - diethyl ester

RTECS #: TD5175000

CAS #: 2310-17-0

UPDATE: August 2003 MW: 367.82 MF: C12H15ClNO4PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Azofene
  2. Benzophosphate
  3. S - ( (3 - Benzoxazolinyl - 6 - chloro - 2 - oxo) methyl) O,O - diethyl phosphorodithioate
  4. Benzphos
  5. Chipman 11974
  6. S - (6 - Chloro - 3 - (mercaptomethyl) - 2 - benzoxazolinone) O,O - diethyl phosphorodithioate
  7. 3 - (6 - Chloro - 2 - oxobenzoxazolin - 3 - yl) methyl O,O - diethyl phosphorothiolothionate
  8. S - ( (6 - Chloro - 2 - oxo - 3 (2H) - benzoxazolyl) methyl) O,O - diethyl phosphorodithioate
  9. O,O - Diaethyl - S - (6 - chlor - benzoxazolon - 2 - on - 3 - yl) - dithiophosphat (German)
  10. O,O - Diaethyl - S - (6 - chlor - 2 - oxo - ben (b) - 1,3 - oxalin - 3 - yl) - methyl - dithiophosphat (German)
  11. O,O - Diethyl - S - ( (6 - chloor - 2 - oxo - benzoxazolin - 3 - yl) - methyl) - dithiofosfaat (Dutch)
  12. O,O - Diethyl S - (6 - chlorobenzoxazolinyl - 3 - methyl) dithiophosphate
  13. O,O - Diethyl S - ( (6 - chloro - 2 - oxobenzoxazolin - 3 - yl) methyl) phosphorodithioate
  14. O,O - Diethyl - S - (6 - chloro - 2 - oxo - benzoxazolin - 3 - yl) methyl - phosphorothiolothionate
  15. 3 - Diethyldithiophosphorylmethyl - 6 - chlorobenzoxazolone - 2
  16. O,O - Diethyl phosphorodithioate, S - ester with 6 - chloro - 3 - (mercaptomethyl) - 2 - benzoxazolinone
  1. O,O - Dietil - S - ( (6 - cloro - 2 - oxo - benzossazolin - 3 - il) - metil) - ditiofosfato (Italian)
  2. ENT 27,163
  3. Fosalon
  4. NPH - 1091
  5. P - 974
  6. NIA - 9241
  7. Niagara 9241
  8. Phosalon
  9. Phosalone
  10. Phosphorodithioic acid - S - ester of 6 - chloro - 3 - mercaptomethylbenzoxazyol - 2 - one
  11. Rhodia RP 11974
  12. RP 11,974
  13. Rubitox
  14. Zolon
  15. Zolone
  16. Zolone PM


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 264 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic PRKHDK 2,169,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
cat 		lethal dose (50 percent kill): 112 mg/kg N/R GTPZAB 14(12),46,1970
oral
chicken 		lethal dose (50 percent kill): 661 mg/kg N/R VETNAL 54(11),75,1978
oral
guinea pig 		lethal dose (50 percent kill): 150 mg/kg N/R GUCHAZ 6,408,1973
oral
mammal (species unspecified) 		lowest published lethal dose: 400 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		IJTHEZ 1,186,1991
oral
mouse 		lethal dose (50 percent kill): 73 mg/kg N/R GTPZAB 19(9),55,1975
oral
rat 		lethal dose (50 percent kill): 85 mg/kg N/R KSKZAN 16(2),59,1978
skin
rat 		lethal dose (50 percent kill): 390 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 1 gm/kg N/R 85DPAN -,-,1971/1976
unreported route
rat 		lethal dose (50 percent kill): 135 mg/kg N/R 30ZDA9 -,371,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 515 µg/kg/24 hour/92 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 41(7),10,1976
oral
dog 		lowest published toxic dose: 3,640 mg/kg/2 year- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 36,561,1976
oral
rat 		lowest published toxic dose: 803 mg/kg/17 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Vascular: Structural changes in vessels 		EKMMA8 18,177,1979
oral
rat 		lowest published toxic dose: 262 mg/kg/3 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		ENVRAL 44,126,1987
oral
rat 		lowest published toxic dose: 524 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 50(2),73,1985
oral
rat 		lowest published toxic dose: 8,925 mg/kg/2 year- continuous Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 36,561,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,142,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1962-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
IJTHEZ International Journal of Toxicology, Occupational and Environmental Health. (Wiley Eastern, 4835/24 Ansari Road, Daryaganj New Delhi 110002, India) V.1- 1991-
KSKZAN Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1963-
PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1- 1975-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as an insecticide and acaricide

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

ALT CAS #: 54182-71-7
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