RTECS:TC8400000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Phosphoric acid, triphenyl ester

RTECS #: TC8400000

CAS #: 115-86-6

UPDATE: November 2004 MW: 326.30 MF: C₁₈H₁₅O₄P

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Celluflex TPP

Disflamoll TP

Phosflex TPP

Reolube TPP

Reomol TPP

TPP

Trifenylfosfat (Czech)

Triphenyl phosphate

Triphenyl phosphate (ACGIH:OSHA)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified) lethal concentration (50 percent kill): 4,200 mg/m³ Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay) GISAAA 39(8),98,1974
intramuscular
rabbit lethal dose : >1 gm/kg N/R NIHBAZ 160,1,1932
intraperitoneal
cat lethal dose : >400 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness AEHLAU 1,33,1960
intraperitoneal
mouse lethal dose (50 percent kill): 1,273 mg/kg N/R ABCHA6 31,1288,1967
intraperitoneal
rat lethal dose : >5 gm/kg Gastrointestinal: Other changes

Skin and Appendages: Other: Hair NTIS OTS0535042
oral
cat lowest published lethal dose: 2 gm/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Muscle weakness ARZNAD 7,585,1957
oral
chicken lowest published lethal dose: 5 gm/kg Spinal Cord: Other degenerative changes NTIS OTS0539872
oral
guinea pig lethal dose : >4 gm/kg N/R AEHLAU 1,33,1960
oral
mouse lethal dose (50 percent kill): 1,320 mg/kg Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay) GISAAA 39(8),98,1974
oral
rat lethal dose (50 percent kill): 3,500 mg/kg Behavioral: Tremor

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea ARZNAD 7,585,1957
oral
rabbit lowest published lethal dose: 3 gm/kg N/R AEHLAU 1,33,1960
subcutaneous
cat lowest published lethal dose: 300 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Muscle weakness NIHBAZ 160,1,1932
subcutaneous
guinea pig lethal dose : >3 gm/kg N/R AEHLAU 1,33,1960
subcutaneous
monkey lowest published lethal dose: 500 mg/kg N/R DTLVS* 4,420,1980
subcutaneous
mouse lethal dose : >3 gm/kg N/R AEHLAU 1,33,1960
subcutaneous
rat lethal dose : >3 gm/kg N/R AEHLAU 1,33,1960
subcutaneous
rabbit lowest published lethal dose: 1 gm/kg N/R AEHLAU 1,33,1960
skin
guinea pig lethal dose (50 percent kill): >4 gm/kg N/R KODAK* 21MAY1971
skin
rabbit lethal dose (50 percent kill): >7,900 mg/kg N/R TXAPA9 41,291,1977

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
cat lowest published toxic dose: 600 mg/kg/10 day- intermittent Behavioral: Tremor

Nutritional and Gross Metabolic: Other changes ARZNAD 7,585,1957
oral
chicken lowest published toxic dose: 25 gm/kg/5 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Ataxia NTIS OTS0539873
oral
rat lowest published toxic dose: 65 gm/kg/65 day- continuous Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Sensory syndrome diagnostic of central lesion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARZNAD 7,585,1957
oral
rat lowest published toxic dose: 59,353 mg/kg/35 day- continuous Liver: Changes in liver weight AEHLAU 1,33,1960
skin
domestic bird lowest published toxic dose: 1,200 mg/kg/3 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Ataxia NEZAAQ 52,281,1997

REVIEWS:
ORGANIZATION STANDARD
REFERENCE**

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3 mg/m³ DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CRTXB2 3,289,1975

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 3 mg/m³ DTLVS* 3,272,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 3 mg/m³ CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 3 mg/m³ CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 3 mg/m³ CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 3 mg/m³ CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 mg/m³, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 3 mg/m³, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m³, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 3 mg/m³, short term exposure limit 6 mg/m³, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 3 mg/m³, JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m³, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m³, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 3 mg/m³, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 3 mg/m³, short term exposure limit 6 mg/m³, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIPHENYL PHOSPHATE-air 10 hour time-weighted average 3 mg/m³ NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74635;
Number of Industries 11;
Total Number of Facilities 341;
Number of Occupations 30;
Total Number of Employees Exposed 7,631
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74635;
Number of Industries 51;
Total Number of Facilities 2,869;
Number of Occupations 54;
Total Number of Employees Exposed 91,754;
Total Number of Female Employees Exposed 22,800

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as fire-resistant plasticizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9169;8EHQ-0892-8839
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9290
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Triphenyl phosphate, 5038

REFERENCES:
CODEN
REFERENCE

ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as fire-resistant plasticizer

NIOSH PROFILE (ARYL PHOSPHATES), SRC, 12/79

NIOSH PROFILE (PLASTIC AND RESIN MANUFACTURE), SRI, 2/77

NIOSH PROFILE (PLASTIC AND RESIN MANUFACTURE), FIRL, 4/78

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