The Registry of Toxic Effects of Chemical Substances

Phosphoric acid, tributyl ester

RTECS #: TC7700000

CAS #: 126-73-8

UPDATE: November 2004 MW: 266.36 MF: C12H27O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. MCS 2495
  2. Butyl phosphate, tri -
  3. Celluphos 4
  4. Tributilfosfato (Italian)
  5. Tributyle (phosphate de) (French)
  6. Tributylfosfaat (Dutch)
  1. Tributylfosfat (Czech)
  2. Tributylphosphat (German)
  3. Tributyl phosphate
  4. Tri - n - butyl phosphate
  5. Tributyl phosphate (ACGIH:OSHA)
  6. TBP


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg severe AJOPAA 29,1363,1946
skin
rabbit 		10 mg/24 hour open irritation test severe JIHTAB 26,269,1944


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 500 µg/plate (+/-enzymatic activation step) GISAAA 51(9),81,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,750 mg/kg (7-17 day pregnant) Reproductive: Other effects on female FCTOD7 32,1031,1994
oral
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** OTS0529384
oral
rat 		lowest published toxic dose: 43,770 mg/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 40,90,1997
oral
rabbit 		lowest published toxic dose: 5,200 mg/kg (6-18 day pregnant) Reproductive: Other effects on female NTIS** OTS0529398


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 229 gm/kg/78 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		TOXID9 36(1,pt2),174,1997
oral
rat 		lowest published toxic dose: 263 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		TOXID9 36(1,pt2),174,1997


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 24,510 mg/m3/5 hour Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		EDWU** -,-,1937
inhalation
mouse 		lethal concentration (50 percent kill): 1,300 mg/m3 N/R GTPZAB 15(8),30,1971
inhalation
rat 		lethal concentration (50 percent kill): 28 gm/m3/1 hour N/R TSCAT* FYI-OTS-0285-0380
intraperitoneal
mouse 		lethal dose (50 percent kill): 159 mg/kg N/R GTPZAB 15(8),30,1971
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Brain and Coverings: Other degenerative changes TOLED5 135,89,2002
intraperitoneal
rat 		lethal dose (50 percent kill): 251 mg/kg N/R GTPZAB 15(8),30,1971
intravenous
rat 		lowest published lethal dose: 100 mg/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		NATUAS 179,154,1957
oral
chicken 		lethal dose (50 percent kill): 1,500 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		TIHEEC 6,415,1990
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 1,189 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 1,189 mg/kg N/R GTPZAB 15(8),30,1971
oral
rat 		lethal dose (50 percent kill): 3 gm/kg N/R JKXXAF #72-18000
subcutaneous
mouse 		lethal dose (50 percent kill): 764 mg/kg N/R JKXXAF #72-18000
skin
rabbit 		lethal dose (50 percent kill): >3,100 mg/kg N/R 85INA8 6,1600,1991
unreported route
mouse 		lethal dose (50 percent kill): 1,200 mg/kg N/R GISAAA 33(7),100,1968
unreported route
rat 		lethal dose (50 percent kill): 1,400 mg/kg N/R GISAAA 33(7),100,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 13,600 mg/m3/5 hour/17 week- intermittent Liver: Liver function tests impaired GTPZAB 15(8),30,1971
inhalation
rat 		lowest published toxic concentration: 15 gm/m3/4 week- intermittent Endocrine: Other changes GISAAA 55(12),56,1990
inhalation
rat 		lowest published toxic concentration: 500 mg/m3/6 hour/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0535406
oral
mouse 		lowest published toxic dose: 109 gm/kg/91 day- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight

Related to Chronic Data: Changes in uterine weight 		JTSCDR 5,270,1980
oral
mouse 		lowest published toxic dose: 33,600 mg/kg/28 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0526409
oral
rat 		lowest published toxic dose: 12,600 mg/kg/10 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 40,247,1997
oral
rat 		lowest published toxic dose: 18,900 mg/kg/9 week- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOLED5 13,29,1982
oral
rat 		lowest published toxic dose: 5,880 µL/kg/4 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve DCTODJ 6,363,1983
oral
rat 		lowest published toxic dose: 27 gm/kg/90 day- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Change in clotting factors

Blood: Changes in erythrocyte (RBC) count 		TOXID9 5,97,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,262,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 ppm (2.5 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 ppm (2.2 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 ppm (2.5 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 ppm (2.5 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.2 ppm (2.5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 ppm (2.5 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, short term exposure limit 5 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIBUTYL PHOSPHATE-air 10 hour time-weighted average 0.2 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 73730;
Number of Industries 25;
Total Number of Facilities 1,209;
Number of Occupations 30;
Total Number of Employees Exposed 30,555
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 73730;
Number of Industries 79;
Total Number of Facilities 4,810;
Number of Occupations 75;
Total Number of Employees Exposed 109,402;
Total Number of Female Employees Exposed 19,015


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as plasticizer, solvent and grinding assistant, also used in inks and dielectrics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tributyl phosphate, 5034


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EDWU** "Beitrag zur Toxikologie Technischer Weichmachungsmittel, Dissertation," Eller, H., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1937
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)

Used as plasticizer, solvent and grinding assistant, also used in inks and dielectrics

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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