The Registry of Toxic Effects of Chemical Substances

Phosphoric acid, 2,2 - dichlorovinyl dimethyl ester

RTECS #: TC0350000

CAS #: 62-73-7

UPDATE: May 2005 MW: 220.98 MF: C4H7Cl2O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. (2,2 - Dichloor - vinyl) - dimethyl - fosfaat (Dutch)
  2. (2,2 - Dichlor - vinyl) - dimethyl - phosphat (German)
  3. (2,2 - Dichloro - vinil) dimetil - fosfato (Italian)
  4. 2,2 - Dichloroethenyl dimethyl phosphate
  5. 2,2 - Dichloroethenyl phosphoric acid dimethyl ester
  6. 2,2 - Dichlorovinyl dimethyl phosphate
  7. 2,2 - Dichlorovinyl dimethyl phosphoric acid ester
  8. Apavap
  9. Astrobot
  10. Atgard
  11. Atgard C
  12. Atgard V
  13. BAY - 19149
  14. Bayer 19149
  15. Benfos
  16. Bibesol
  17. Brevinyl
  18. Brevinyl E50
  19. Canogard
  20. Chlorvinphos
  21. Cypona
  22. DDVP
  23. DDVP (OSHA)
  24. DDVP (insecticide)
  25. Dedevap
  26. Denkavepon
  27. Deriban
  28. Derribante
  29. Devikol
  30. Dichlofos
  31. Dichloorvo (Dutch)
  32. Dichlorfos (Polish)
  33. Dichlorman
  34. Dichlorovos
  35. Dichlorvos
  36. Dichlorvos (ACGIH:OSHA)
  37. Dimethyl 2,2 - dichloroethenyl phosphate
  38. Dimethyl 2,2 - dichlorovinyl phosphate
  39. Dimethyl dichlorovinyl phosphate
  40. Divipan
  41. ENT 20738
  42. Equigard
  43. Equigel
  44. Estrosel
  45. Estrosol
  46. Ethenol, 2,2 - dichloro - , dimethyl phosphate
  47. Fecama
  48. Fekama
  49. Fly fighter
  1. Fly - Die
  2. Insectigas D
  3. MAFU strip
  4. Marvex
  5. Mopari
  6. NCI - C00113
  7. NO - Pest
  8. NO - Pest strip
  9. NSC - 6738
  10. Nefrafos
  11. Nerkol
  12. Nogos
  13. Nogos 50
  14. Nogos 50 EC
  15. Nogos G
  16. Novotox
  17. Nuvan
  18. Nuvan 100EC
  19. Nuvan 7
  20. O,O - Dimethyl 2,2 - dichlorovinyl phosphate
  21. O,O - Dimethyl O - 2,2 - dichlorovinyl phosphate
  22. O,O - Dimethyl dichlorovinyl phosphate
  23. O,O - Dimethyl - O - (2,2 - dichlor - vinyl) - phosphat (German)
  24. O,O - Dwumetylo - O - dwuchlorowinylofosforan (Polish)
  25. O,O - dimethyl - O - (2,2 - dichlorovinyl) phosphate
  26. O - (2,2 - Dichlorvinyl) - O,O - dimethylphosphat (German)
  27. OKO
  28. OMS 14
  29. Panaplate
  30. Phosphate de dimethyle et de 2,2 - dichlorovinyle (French)
  31. Phosphoric acid, 2,2 - dichloroethenyl dimethyl ester (9CI)
  32. Phosvit
  33. SD - 1750
  34. Szklarniak
  35. TAP 9VP
  36. Task
  37. Tetravos
  38. Unifos
  39. Unifos (pesticide)
  40. Unifos 50 EC
  41. Unitox
  42. Vapona
  43. Vapona insecticide
  44. Vaponite
  45. Vapora II
  46. Vinyl alcohol, 2,2 - dichloro - , dimethyl phosphate
  47. Vinylofos
  48. Vinylophos
  49. Winylophos


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
hamster 		3 mg/kg ARTODN 58,152,1986
cytogenetic analysis hamster lung 100 mg/L AMONDS 3,253,1980
cytogenetic analysis hamster ovary 160 mg/L NTPTR* NTP-TR-342,1989
cytogenetic analysis human lymphocyte 1 mg/L TSITAQ 18,1490,1976
cytogenetic analysis multiple
other fish 		10 ppb MUREAV 344,1,1995
cytogenetic analysis rat other cell types 80 mg/L MUREAV 206,439,1988
DNA damage Escherichia coli 1 gm/L MUREAV 52,161,1978
DNA damage hamster lung 2,000 ppm/60 minute MUREAV 24,365,1974
DNA damage human lymphocyte 62 mg/L TUMOAB 66,425,1980
DNA damage human HeLa cell 970 µmol/L CBINA8 8,171,1974
DNA damage mammal (species unspecified) lymphocyte 100 µL NATWAY 57,393,1970
DNA damage intraperitoneal
mouse 		420 µg/kg APTSAI 49(5),56,1981
DNA damage inhalation
mouse 		8 mg/kg PCBPBS 6,101,1976
DNA damage salmon sperm 14 mmol/L CBINA8 8,171,1974
DNA inhibition human lymphocyte 62 mg/L TUMOAB 66,425,1980
DNA repair Bacillus subtilis 10 pph MUREAV 40,19,1976
DNA repair Escherichia coli 60 nmol/plate CNREA8 33,458,1973
DNA repair other microorganisms 10 µmol/plate CBINA8 39,339,1982
unscheduled DNA synthesis human other cell types 65 mmol/L PSSCBG 15,439,1984
host-mediated assay mouse
Saccharomyes cerevisiae 		4 mg/L ATXKA8 30,61,1972
mutation in microorganisms Aspergillus nidulans 14 mg/plate (-enzymatic activation step) MUREAV 46,395,1977
mutation in microorganisms Escherichia coli 5 pph (-enzymatic activation step) MUREAV 40,19,1976
mutation in microorganisms Klebsiella pneumoniae 1,000 ppm (-enzymatic activation step) MUREAV 16,413,1972
mutation in microorganisms other microorganisms 5,600 µg/plate (-enzymatic activation step) CBINA8 22,297,1978
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) MUREAV 16,413,1972
mutation in microorganisms other microorganisms 80 mmol/L (-enzymatic activation step) MUREAV 21,175,1973
mutation in microorganisms Salmonella typhimurium 333 µg/plate (+enzymatic activation step) EMMUEG 11(Suppl 12),1,1988
mutation in microorganisms Serratia marcescens 25 mg/L (-enzymatic activation step) ATXKA8 30,67,1972
mutation in microorganisms Schizosaccharomyces pombe 5 mmol/L (-enzymatic activation step) MUREAV 117,139,1983
mutation in microorganisms Schizosaccharomyces pombe 5 mmol/L (+enzymatic activation step) MUREAV 117,139,1983
gene conversion and mitotic recombination Aspergillus nidulans 28 mg/plate MUREAV 46,395,1977
gene conversion and mitotic recombination Saccharomyes cerevisiae 19 mmol/L/6 hour IARCCD 10,161,1974
mutation in mammalian somatic cells mouse lymphocyte 12,500 mg/L NTPTR* NTP-TR-342,1989
mutation in mammalian somatic cells intraperitoneal
mouse 		55 mg/kg/22 day- intermittent CALEDQ 146,155,1999
morphological transform hamster embryo 110 µmol/L ENMUDM 8,515,1986
morphological transform rat other cell types 40 mg/L MUREAV 206,439,1988
other mutation test systems Escherichia coli 3,820 nmol/L EMMUEG 19,98,1992
phage inhibition capacity Escherichia coli 70 µmol/L MUREAV 182,193,1987
phage inhibition capacity Escherichia coli 0.284 mmol/L (+enzymatic activation step) EMMUEG 36,206,2000
sister chromatid exchange hamster ovary 30 µmol/L JTEHD6 8,939,1981
sister chromatid exchange hamster lung 100 µmol/L MUREAV 78,177,1980
sister chromatid exchange rat other cell types 10 mg/L MUREAV 206,439,1988
sex chromosome loss and nondisjunction Aspergillus nidulans 800 mg/L EVHPAZ 31,81,1979
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		750 ppb MUREAV 28,405,1975
sperm morphology intraperitoneal
mouse 		35 mg/kg/5 day PNASA6 72,4425,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rabbit 		lowest published toxic concentration: 4 mg/m3/23 hour (1-28 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ATXKA8 30,29,1972
intraperitoneal
rat 		lowest published toxic dose: 15 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Body wall AEHLAU 16,805,1968
oral
mouse 		lowest published toxic dose: 180 mg/kg (18 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) BECTA6 11(5),429,1974
oral
pig 		lowest published toxic dose: 255 mg/kg (41-70 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Endocrine system 		ZVRAAX 27,662,1980
oral
pig 		lowest published toxic dose: 759 mg/kg (1-15 week pregnant/4 week after birth) Reproductive: Effects on newborn: Biochemical and metabolic CNJNAT 71,227,1991
oral
rat 		lowest published toxic dose: 39,200 µg/kg (14-21 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic NUPOBT 15,255,1977
oral
rat 		lowest published toxic dose: 220 mg/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects 		IJEREO 5,239,1995
oral
rat 		lowest published toxic dose: 80 mg/kg (6-15 day pregnant) Reproductive: Effects on newborn: Behavioral NETEEC 26,607,2004
oral
rabbit 		lowest published toxic dose: 65 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 20,383,1979
oral
rabbit 		lowest published toxic dose: 60 mg/kg (22-31 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic FHCYAI 16,335,1978
unreported route
guinea pig 		lowest published toxic dose: 90 mg/kg (42-44 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NEREDZ 19,569,1994
unreported route
rat 		lowest published toxic dose: 40 mg/kg (2 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		BECTA6 15,458,1976
unreported route
rabbit 		lowest published toxic dose: 60 mg/kg (22-31 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic FHCYAI 16,139,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 20,600 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-342,1989
oral
mouse 		lowest published toxic dose: 10,300 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB90-198508
oral
mouse 		lowest published toxic dose: 20,600 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB90-198508
oral
rat 		lowest published toxic dose: 4,120 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors 		NTPTR* NTP-TR-342,1989
oral
rat 		lowest published toxic dose: 2,060 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Blood: Leukemia 		JJCREP 82,157,1991
oral
rat 		lowest published toxic dose: 2,060 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Blood: Leukemia 		NTIS** PB90-198508
oral
rat 		lowest published toxic dose: 2,060 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB90-198508


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 13 mg/m3/4 hour Eye: Lacrimation

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands 		GISAAA 33(12),35,1968
inhalation
rat 		lethal concentration (50 percent kill): 15 mg/m3/4 hour Eye: Lacrimation

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands 		GISAAA 33(12),35,1968
intramuscular
rat 		lethal dose (50 percent kill): 10.2 mg/kg N/R EKFAE9 56,57,1993
intramuscular
rat 		lethal dose (50 percent kill): 1.5 mg/kg Behavioral: Anticonvulsant EKFAE9 62,55,1999
intraperitoneal
hamster 		lethal dose (50 percent kill): 30 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 22 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAFCAU 11,91,1963
intraperitoneal
mouse 		lowest published toxic dose: 19.7 mg/kg Behavioral: Convulsions or effect on seizure threshold TOSCF2 72,289,2003
intraperitoneal
mouse 		lowest published lethal dose: 22.4 mg/kg Behavioral: Convulsions or effect on seizure threshold TOSCF2 72,289,2003
intraperitoneal
rat 		lethal dose (50 percent kill): 15 mg/kg Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		APTSAI 49(5),67,1981
intraperitoneal
rat 		lowest published toxic dose: 8 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 135,S86,2002
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		FATOAO 44,334,1981
intravenous
dog 		lowest published lethal dose: 2,200 µg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting 		AUVJA2 49,113,1973
intravenous
mouse 		lethal dose (50 percent kill): 18 mg/kg N/R CSLNX* NX#00004
oral
wild bird 		lethal dose (50 percent kill): 12 mg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 6,450 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase INJPD2 10,323,1978
oral
duck 		lethal dose (50 percent kill): 7,800 µg/kg N/R DOEAAH 35,25,1979
oral
dog 		lethal dose (50 percent kill): 100 mg/kg N/R 85JFAN A141,1984
oral
mouse 		lethal dose (50 percent kill): 61 mg/kg N/R OSDIAF 15,553,1966
oral
mouse 		lowest published toxic dose: 40 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		BECTA6 11,429,1974
oral
pigeon 		lethal dose (50 percent kill): 23,700 µg/kg N/R ASTTA8 (680),157,1979
oral
pig 		lethal dose (50 percent kill): 157 mg/kg Gastrointestinal: Nausea or vomiting

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		AJVRAH 40,315,1979
oral
quail 		lethal dose (50 percent kill): 22,010 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea 		HOEKAN 24,35,1974
oral
rat 		lethal dose (50 percent kill): 17 mg/kg N/R JPIFAN (13),36,1972
oral
rabbit 		lethal dose (50 percent kill): 10 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		BEXBAN 83,32,1977
parenteral
man 		lowest published lethal dose: 35.7 mg/kg Eye: Miosis (pupilliary constriction)

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression 		AJEMEN 18,640,2000
subcutaneous
mouse 		lethal dose (50 percent kill): 24 mg/kg Behavioral: Convulsions or effect on seizure threshold

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea 		IMSUAI 31,170,1962
subcutaneous
rat 		lethal dose (50 percent kill): 10,800 µg/kg N/R APYPAY 32,507,1981
subcutaneous
rat 		lowest published lethal dose: 25 mg/kg Lung, Thorax, or Respiration: Respiratory obstruction AEMME* 9,1369,2002
subcutaneous
rat 		lowest published toxic dose: 13 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides 		TXCYAC 191,35,2003
skin
mouse 		lethal dose (50 percent kill): 206 mg/kg N/R ABCHA6 27,684,1963
skin
rat 		lethal dose (50 percent kill): 750 µg/kg N/R TOVEFN (2),35,1995
skin
rabbit 		lethal dose (50 percent kill): 107 mg/kg N/R BESAAT 12,117,1966
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 125 mg/kg N/R GISAAA 41(8),82,1976
unreported route
mouse 		lethal dose (50 percent kill): 75 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 33(12),35,1968
unreported route
rat 		lethal dose (50 percent kill): 57 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 33(12),35,1968
unreported route
rat 		lethal dose (50 percent kill): 40 mg/kg N/R FATOAO 50,97,1987
unreported route
rabbit 		lethal dose (50 percent kill): 23 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 33(12),35,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic dose: 8,200 µg/m3/45 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GISAAA 33(12),35,1968
intraperitoneal
rat 		lowest published toxic dose: 16 mg/kg/2 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 135,S86,2002
intraperitoneal
rat 		lowest published toxic dose: 24 mg/kg/3 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 135,S86,2002
intraperitoneal
rat 		lowest published toxic dose: 150 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		EXMPA6 56,144,1992
oral
chicken 		lowest published toxic dose: 2,450 mg/kg/28 day- continuous Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		INJPD2 10,323,1978
oral
dog 		lowest published toxic dose: 56,250 µg/kg/90 day- continuous Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Urine volume increased

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NYZZA3 26,739,1974
oral
domestic animal 		lowest published toxic dose: 112 mg/kg/28 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		IVEJAC 66,821,1989
oral
mouse 		lowest published toxic dose: 5,200 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-342,1989
oral
mouse 		lowest published toxic dose: 90 mg/kg/9 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct BECTA6 11,429,1974
oral
mouse 		lowest published toxic dose: 180 mg/kg/18 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) BECTA6 11,429,1974
oral
rat 		lowest published toxic dose: 360 mg/kg/90 day- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		BCTKAG 21,31,1988
oral
rat 		lowest published toxic dose: 56 mg/kg/14 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases 		BCTKAG 7,201,1974
oral
rat 		lowest published toxic dose: 45 mg/kg/6 week- intermittent Brain and Coverings: Changes in surface EEG

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NETEEC 10,429,1988
oral
rat 		lowest published toxic dose: 150 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA -,64,1993
oral
rat 		lowest published toxic dose: 70 mg/kg/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 18,231,1977
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg/10 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JHSCFD 45,191,1999
subcutaneous
rat 		lowest published toxic dose: 28 mg/kg/28 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		APYPAY 31,575,1980
subcutaneous
rat 		lowest published toxic dose: 21,600 µg/kg/17 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		APYPAY 32,507,1981
skin
monkey 		lowest published toxic dose: 750 mg/kg/10 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		AMIHAB 15,340,1957
skin
monkey 		lowest published toxic dose: 400 mg/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field YKYUA6 30,1229,1979
skin
rat 		lowest published toxic dose: 141 mg/kg/17 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		APYPAY 32,507,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin, sen) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 53,267,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 20,97,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 20,97,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,267,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 53,267,1991
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
MUREAV 32,133,1975
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
NYZZA3 26,739,1974
TOXICOLOGY REVIEW
NWSCAL 53,489,1972
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
ALLVAR 50,77,1962
TOXICOLOGY REVIEW
TOLED5 128,45,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,107,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (1.0 mg/m3) DTLWS* 3,16,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (1 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 01 ppm (0.9 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, Skin, 2003
Occupational Exposure Limit - INDIA time-weighted average 0.1 ppm (1 mg/m3), Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.92 mg/m3), short term exposure limit 0.3 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLORVOS-air 10 hour time-weighted average 1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0377;
Number of Industries 16;
Total Number of Facilities 2,139;
Number of Occupations 20;
Total Number of Employees Exposed 29,515
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0377;
Number of Industries 10;
Total Number of Facilities 1,356;
Number of Occupations 17;
Total Number of Employees Exposed 24,205;
Total Number of Female Employees Exposed 2,466


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101124/AS)
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; TRP reversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Negative: Cytogenetics-male germ cell; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: Mammalian micronucleus; In vitro SCE-human lymphocytes
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insecticide and as an anthelminthic for swine and dogs
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-342,1989
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
OSHA ANALYTICAL METHOD #62


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Used as an insecticide and as an anthelminthic for swine and dogs

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Organometallic
   Mutagen
   Reproductive Effector

ALT CAS #: 8023-22-1
ALT CAS #: 8072-21-7
ALT CAS #: 8072-39-7
ALT CAS #: 11095-17-3
ALT CAS #: 11096-21-2
ALT CAS #: 12772-40-6
ALT CAS #: 55819-32-4
ALT CAS #: 62139-95-1
ALT CAS #: 95828-55-0
ALT CAS #: 116788-91-1
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