The Registry of Toxic Effects of Chemical Substances

Phosphoric acid, 1,2 - dibromo - 2,2 - dichloroethyl dimethyl ester

RTECS #: TB9450000

CAS #: 300-76-5

UPDATE: November 2004 MW: 380.80 MF: C4H7Br2Cl2O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2 - Dibromo - 2,2 - dichloroethyl dimethyl phosphate
  2. Alvora
  3. Arthodibrom
  4. Bromchlophos
  5. Bromex (insecticide)
  6. Dibrom
  7. Dibromfos
  8. Dimethyl 1,2 - dibromo - 2,2 - dichloroethyl phosphate
  9. Dimethyl - 1,2 - dibromo - 2,2 - dichloroethyl phosphate (OSHA)
  10. ENT 24988
  11. Ethanol, 1,2 - dibromo - 2,2 - dichloro - , dimethyl phosphate
  12. Flibol Ex
  13. Fosforan O - 1,2 - dwubromo - 2,2 - dwuchloroetylo - O,O - dwumetylowy (Polish)
  14. Hibrom
  1. Naled
  2. Naled (ACGIH)
  3. Naledu (Polish)
  4. O,O - Dimethyl O - 2,2 - dichloro - 1,2 - dibromoethyl phosphate
  5. O,O - Dimethyl - O - (1,2 - dibrom - 2,2 - dichlor - aethyl) - phosphat (German)
  6. O,O - Dimethyl - O - (1,2 - dibromo - 2,2 - dichloroethyl) phosphate
  7. O - (1,2 - Dibrom - 2,2 - dichlor - aethyl) - O,O - dimethyl - phosphat (German)
  8. O - (1,2 - Dibromo - 2,2 - dicloro - etil) - O,O - dimetil - fosfato (Italian)
  9. O - (1,2 - Dibroom - 2,2 - dichloor - ethyl) - O,O - dimethyl - fosfaat (Dutch)
  10. OMS 75
  11. Ortho 4355
  12. Phosphate de O,O - dimethyle et de O - (1,2 - dibromo - 2,2 - dichlorethyle) (French)
  13. RE - 4355


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
man 		42 mg/21 day- intermittent open irritation test N/R TXAPA9 21,369,1972
skin
rabbit 		500 mg/24 hour severe TXAPA9 21,369,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Bacillus subtilis 300 µg/plate (+enzymatic activation step) JAFCAU 29,268,1981
mutation in microorganisms Salmonella typhimurium 9,800 µg/plate (+enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) JAFCAU 29,268,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration : >1,500 mg/m3/6 hour N/R 85JFAN A289,1983
intraperitoneal
mouse 		lethal dose (50 percent kill): 84 mg/kg N/R 85GMAT -,56,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 35 mg/kg N/R BECTA6 19,113,1978
oral
duck 		lethal dose (50 percent kill): 52 mg/kg N/R DOEAAH 35,25,1979
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 430 mg/kg N/R HPBIA9 21,53,1975
oral
mouse 		lethal dose (50 percent kill): 222 mg/kg Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		BECTA6 19,113,1978
oral
rat 		lethal dose (50 percent kill): 92 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea 		ATDAEI 1,90,1990
skin
mouse 		lethal dose (50 percent kill): 600 mg/kg N/R JPIFAN (8),24,1971
skin
rat 		lethal dose (50 percent kill): 800 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 1,100 mg/kg N/R 28ZEAL 5,161,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,350 mg/kg/9 week- intermittent Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		RPZHAW 20,463,1969


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin, sen) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
DTTIAF 80,485,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,135,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 3 mg/m3 DTLVS* 3,73,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 3 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 3 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 3 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 3 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 3 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 3 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 3 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit - THAILAND time-weighted average 3 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 3 mg/m3, short term exposure limit 6 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 3 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26420;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 1;
Total Number of Employees Exposed 16


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11- 1965-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used in insecticides and acaricides

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Primary Irritant

ALT CAS #: 53095-31-1
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