The Registry of Toxic Effects of Chemical Substances

Phosphoric acid

RTECS #: TB6300000

CAS #: 7664-38-2

UPDATE: November 2004 MW: 98.00 MF: H3O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Acide phosphorique (French)
  2. Acido fosforico (Italian)
  3. Fosforzuuroplossingen (Dutch)
  4. Hydrogen phosphate
  1. Orthophosphoric acid
  2. Phosphoric acid (ACGIH:OSHA)
  3. Phosphorsaeureloesungen (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		119 mg severe BIOFX* 17-4/1970
skin
rabbit 		595 mg/24 hour severe BIOFX* 17-4/1970


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 25.5 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight 		VCVN5* -,73,1993
inhalation
rat 		lethal concentration (50 percent kill): >850 mg/m3/1 hour N/R BIOFX* 17-4/1970
inhalation
rat 		lethal concentration (50 percent kill): 25.5 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight 		VCVN5* -,73,1993
oral
mouse 		lethal dose (50 percent kill): 1.25 gm/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight 		VCVN5* -,73,1993
oral
rat 		lethal dose (50 percent kill): 1,530 mg/kg Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Hematuria

Skin and Appendages: Other: Hair 		BIOFX* 17-4/1970
oral
rat 		lethal dose (50 percent kill): 1.25 gm/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight 		VCVN5* -,73,1993
skin
rabbit 		lethal dose (50 percent kill): 2,740 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement 		BIOFX* 17-4/1970
unreported route
man 		lowest published lethal dose: 220 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3;short term exposure limit 3 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 3 mg/m3 DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
ARTODN 39,299,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,325,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg/m3 DTLVS* 3,210,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 mg/m3, VLE 3 mg/m3, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 1 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 1 mg/m3, KTV 3 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 2 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 3 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 3 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORIC ACID-air 10 hour time-weighted average 1 mg/m3;
short term exposure limit 3 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 58520;
Number of Industries 257;
Total Number of Facilities 42,406;
Number of Occupations 146;
Total Number of Employees Exposed 454,920
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 58520;
Number of Industries 309;
Total Number of Facilities 61,396;
Number of Occupations 198;
Total Number of Employees Exposed 1,256,907;
Total Number of Female Employees Exposed 450,478


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
OSHA ANALYTICAL METHOD #ID-111


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Top 50 chemical production: 25.36 billions lbs in 1992, 24.11 billions in 1991

NIOSH PROFILE (FERTILIZER MANUFACTURE), SRC, 3/80

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

 Click Here for Additional Information about RTECS