The Registry of Toxic Effects of Chemical Substances

Phosphoramidothioic acid, O,S - dimethyl ester

RTECS #: TB4970000

CAS #: 10265-92-6

UPDATE: November 2004 MW: 141.14 MF: C2H8NO2PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. BAY 71628
  2. Bayer 71628
  3. Chevron 9006
  4. Chevron ortho 9006
  5. O,S - Dimethyl ester amide of amidothioate
  6. O,S - Dimethyl phosphoramidothioate
  7. ENT 27,396
  8. Metamidofos estrella
  9. Methamidophos
  10. Monitor
  1. NSC 190987
  2. Ortho 9006
  3. Acephate - met
  4. Hamidop
  5. SRA 5172
  6. Pillaron
  7. Tahmabon
  8. Tamaron
  9. Thiophosphorsaeure - O,S - dimethylesteramid (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis mouse other cell types 2 mg/L ZNCBDA 42,21,1987
micronucleus test intraperitoneal
mouse 		6 mg/kg ZNCBDA 42,21,1987
micronucleus test oral
mouse 		84 mg/kg/1 week- continuous ZNCBDA 42,21,1987
micronucleus test skin
mouse 		96 mg/kg/2 week- intermittent ZNCBDA 42,21,1987
sister chromatid exchange intraperitoneal
mouse 		6 mg/kg ZNCBDA 42,21,1987
sister chromatid exchange mouse other cell types 250 µg/L ZNCBDA 42,21,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 3,750 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 165,148,2000
oral
mouse 		lowest published toxic dose: 4 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		ZYYZEW 2,142,1988
oral
rat 		lowest published toxic dose: 10 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear 		VEMJA8 34,357,1986
oral
rat 		lowest published toxic dose: 6 mg/kg (1-6 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Urogenital system 		VHTODE 42,361,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 162 mg/m3/4 hour N/R 85JFAN A265,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 5,300 µg/kg N/R PCBPBS 7,83,1977
intraperitoneal
mouse 		lowest published toxic dose: 3 mg/kg Brain and Coverings: Other degenerative changes TOLED5 135,89,2002
intraperitoneal
rat 		lethal dose (50 percent kill): 15 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair 		PCBPBS 13,267,1980
intravenous
rat 		lethal dose (50 percent kill): 10 mg/kg Eye: Lacrimation

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands 		PCBPBS 18,28,1982
oral
domestic bird 		lethal dose (50 percent kill): 8 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		AECTCV 10,185,1981
oral
chicken 		lethal dose (50 percent kill): 25 mg/kg N/R 28ZEAL 5,149,1976
oral
guinea pig 		lethal dose (50 percent kill): 30 mg/kg N/R 28ZEAL 5,149,1976
oral
man 		lowest published toxic dose: 1,429 µL/kg Behavioral: General anesthetic

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation 		ARTODN 73,296,1999
oral
man 		lowest published toxic dose: 257 mg/kg Peripheral Nerve and Sensation: Fasciculations

Eye: Miosis (pupilliary constriction)

Skin and Appendages: Other: Sweating 		NEJMAG 306,125,1982
oral
man 		lowest published toxic dose: 600 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Autonomic Nervous System: Parasympatholytic

Behavioral: Coma 		TOXID9 14,390,1994
oral
mouse 		lethal dose (50 percent kill): 14 mg/kg N/R PCBPBS 7,83,1977
oral
quail 		lethal dose (50 percent kill): 57,500 µg/kg N/R PEMNDP 9,563,1991
oral
rat 		lethal dose (50 percent kill): 7,500 µg/kg N/R ARSIM* 20,7,1966
oral
rabbit 		lethal dose (50 percent kill): 10 mg/kg N/R 28ZEAL 5,149,1976
oral
woman 		lowest published toxic dose: 360 mg/kg Peripheral Nerve and Sensation: Fasciculations

Eye: Miosis (pupilliary constriction)

Skin and Appendages: Other: Sweating 		NEJMAG 306,125,1982
oral
woman 		lowest published toxic dose: 26.3 ppm Eye: Miosis (pupilliary constriction)

Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting 		JTCTDW 39,333,2001
subcutaneous
guinea pig 		lowest published lethal dose: 10 mg/kg N/R JEENAI 62,934,1969
skin
rat 		lethal dose (50 percent kill): 50 mg/kg N/R 28ZEAL 5,149,1976
skin
rabbit 		lethal dose (50 percent kill): 118 mg/kg N/R GUCHAZ 6,333,1973
unreported route
mouse 		lethal dose (50 percent kill): 27 mg/kg N/R JAFCAU 18,189,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 71,890 µg/kg/13 week- continuous Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		FAATDF 35,101,1997
oral
rat 		lowest published toxic dose: 90 µL/kg/9 day- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		EVMJB9 49,833,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
TOLED5 128,45,2002
TOXICOLOGY REVIEW
TOLED5 127,29,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,130,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
EVMJB9 Journal of the Egyptian Veterinary Medical Association. (Egyptian Veterinary Medical Association, 8, 26 July St., Cairo, Egypt) V.27- 1967-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VEMJA8 Veterinary Medical Journal. (Cairo Univ., Faculty of Veterinary Medicine, Giza, Egypt) V.1-36, 1953-88. For publisher information, see VMJGEA
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep. Ger.) V.29- 1974-
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986-

Used to control certain lepidopterous larvae, aphids, mites and whiteflies

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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