The Registry of Toxic Effects of Chemical Substances

Phosphoramidic acid, isopropyl - , 4 - (methylthio) - m - tolyl ethyl ester

RTECS #: TB3675000

CAS #: 22224-92-6

UPDATE: May 2005 MW: 303.39 MF: C13H22NO3PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - (Methylethyl) - ethyl 3 - methyl - 4 - (methylthio) phenyl phosphoramidate
  2. BAY 68138
  3. BAY sra 3886
  4. ENT 27572
  5. Ethyl 3 - methyl - 4 - (methylthio) phenyl (1 - methylethyl) phosphoramidate
  6. Ethyl 4 - (methylthio) - m - tolyl isopropylphosphoramidate
  7. Fenamiphos
  8. Fenamiphos (ACGIH)
  1. Isopropylamino - O - ethyl - (4 - methylmercapto - 3 - methylphenyl) phosphate
  2. NSC 195106
  3. Nemacur
  4. Nemacur P
  5. O - Aethyl - O - (3 - methyl - 4 - methylthiophenyl) - isopropylamido - phosphorsaeureester (German)
  6. Phenamiphos
  7. Phosphoramidic acid, (1 - methylethyl) - , ethyl (3 - methyl - 4 - (methylthio) phenyl) ester
  8. SRA 3886


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 30 mg/kg (6-15 day pregnant) Reproductive: Other effects on female TIHEEC 14,869,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 91 mg/m3/4 hour N/R 85DPAN -,-,1971/1976
oral
domestic bird 		lethal dose (50 percent kill): 2,400 痢/kg N/R 85KYAH 11,621,1989
oral
cat 		lethal dose (50 percent kill): 10 mg/kg N/R 85DPAN -,-,1971/1976
oral
chicken 		lethal dose (50 percent kill): 12 mg/kg N/R PEMNDP 9,361,1991
oral
duck 		lethal dose (50 percent kill): 1,680 痢/kg N/R TXAPA9 47,451,1979
oral
dog 		lethal dose (50 percent kill): 10 mg/kg N/R 28ZEAL 5,112,1976
oral
mouse 		lethal dose (50 percent kill): 22,700 痢/kg N/R 85DPAN -,-,1971/1976
oral
quail 		lethal dose (50 percent kill): 1 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		EESADV 8,551,1984
oral
rat 		lethal dose (50 percent kill): 8 mg/kg N/R BESAAT 15,116,1969
oral
rat 		lowest published toxic dose: 3.5 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NETEEC 26,407,2004
oral
rat 		lowest published toxic dose: 7 mg/kg Eye: Lacrimation

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning 		NETEEC 26,407,2004
oral
rabbit 		lethal dose (50 percent kill): 10 mg/kg N/R DTLWS* 4,191,1982
skin
duck 		lethal dose (50 percent kill): 24 mg/kg N/R TXAPA9 47,451,1979
skin
rat 		lethal dose (50 percent kill): 80 mg/kg N/R FMCHA2 -,C216,1991
skin
rabbit 		lethal dose (50 percent kill): 178 mg/kg N/R DTLWS* 4,191,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,119,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FENAMIPHOS-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
BESAAT Bulletin of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

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