The Registry of Toxic Effects of Chemical Substances

Phosphonic acid, (2,2,2 - trichloro - 1 - hydroxyethyl) - , dimethyl ester

RTECS #: TA0700000

CAS #: 52-68-6

UPDATE: May 2005 MW: 257.44 MF: C4H8Cl3O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. ( (2,2,2 - Trichloro - 1 - hydroxyethyl) dimethylphosphonate)
  2. (2,2,2 - Trichloro - 1 - hydroxyethyl) phosphonic acid dimethyl ester
  3. 1 - Hydroxy - 2,2,2 - trichloro - ethyle phosphonate de dimethyle (French)
  4. 1 - Hydroxy - 2,2,2 - trichloroethylphosphonic acid dimethyl ester
  5. 2,2,2 - Trichloroethyl dimethyl phosphate
  6. Aerol 1
  7. Aerol 1 (pesticide)
  8. Agroforotox
  9. Anthon
  10. BAY 15922
  11. WEC 50
  12. Wotexit
  13. Bayer 15922
  14. Bayer L 13/59
  15. Bilarcil
  16. Bovinox
  17. Briton
  18. Britten
  19. Cekufon
  20. Chlorak
  21. Chlorfos
  22. Chlorofos
  23. Chloroftalm
  24. Chlorophos
  25. Chlorophose
  26. Chlorophthalm
  27. Chloroxyphos
  28. Ciclosom
  29. Combot
  30. Combot equine
  31. DEP (pesticide)
  32. DETF
  33. Danex
  34. Depthon
  35. Dimethoxy - 2,2,2 - trichloro - 1 - hydroxy - ethyl - phosphine oxide
  36. Dimethyl 1 - hydroxy - 2,2,2 - trichloroethyl phosphonate
  37. Dimethyl 2,2,2 - trichloro - 1 - hydroxyethylphosphonate
  38. Dimethyltrichlorohydroxyethyl phosphonate
  39. Dimetox
  40. Dipterex
  41. Dipterex 50
  42. Diptevur
  43. Ditrifon
  44. Dylox
  45. Dylox - metasystox - R
  46. Dyrex
  47. Dyvon
  48. ENT 19,763
  49. Equino - aid
  50. Flibol E
  51. Fliegenteller
  1. Forotox
  2. Foschlor
  3. Foschlor 25
  4. Foschlor R
  5. Foschlor R - 50
  6. Foschlorem (Polish)
  7. Hypodermacid
  8. Leivasom
  9. Loisol
  10. Masoten
  11. Mazoten
  12. Methyl chlorophos
  13. Metrifonate
  14. Metriphonate
  15. NCI - C54831
  16. Neguvon
  17. O,O Dimetil 2,2,2 - trichloro 1 hidroxietil fosfonato (Portugese)
  18. O,O - Dimethyl (1 - hydroxy - 2,2,2 - trichloroethyl) phosphonate
  19. O,O - Dimethyl (2,2,2 - trichloro - 1 - hydroxyethyl) phosponate
  20. O,O - Dimethyl - (1 - hydroxy - 2,2,2 - trichloraethyl) phosphonsaeure ester (German)
  21. O,O - Dimethyl - (1 - hydroxy - 2,2,2 - trichlorathyl) - phosphat (German)
  22. O,O - Dimethyl - (1 - hydroxy - 2,2,2 - trichloro) ethyl phosphate
  23. O,O - Dimethyl - (2,2,2 - trichloor - 1 - hydroxy - ethyl) - fosfonaat (Dutch)
  24. O,O - Dimethyl - (2,2,2 - trichlor - 1 - hydroxy - aethyl) phosphonat (German)
  25. O,O - Dimethyl - 1 - oxy - 2,2,2 - trichloroethyl phosphonate
  26. O,O - Dimetil - (2,2,2 - tricloro - 1 - idrossi - etil) - fosfonato (Italian)
  27. Phoschlor
  28. Phoschlor R50
  29. Phosphonic acid, (1 - hydroxy - 2,2,2 - trichloroethyl) - , dimethyl ester
  30. Polfoschlor
  31. Proxol
  32. Ricifon
  33. Ritsifon
  34. Satox 20WSC
  35. Soldep
  36. Sotipox
  37. Trichloorfon (Dutch)
  38. Trichlorfon
  39. Trichlorfon (German)
  40. Trichlorofon
  41. Trichlorophon
  42. Trichlorphon
  43. Trichlorphon FN
  44. Trinex
  45. Tugon
  46. Tugon fly bait
  47. Tugon stable spray
  48. Vermicide bayer 2349
  49. Volfartol
  50. Votexit


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		120 mg/6 day- intermittent mild BUMMAB 9,7,1955


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay mouse
Salmonella typhimurium 		200 mg/kg CNREA8 38,4478,1978
cytogenetic analysis hamster lung 81 mg/L GMCRDC 27,95,1981
cytogenetic analysis human leukocyte 40 mg/L HOEKAN 29,33,1979
cytogenetic analysis oral
mouse 		100 mg/kg SOGEBZ 11,1534,1975
cytogenetic analysis oral
mouse 		8,500 µg/kg GISAAA 45(1),80,1980
cytogenetic analysis intraperitoneal
mouse 		51,500 µg/kg EESADV 13,216,1987
cytogenetic analysis mouse ovary 50 µg/plate/16 hour MUREAV 564,165,2004
cytogenetic analysis multiple
other fish 		1 µL/L JFIBA9 26,13,1985
dominant lethal test intraperitoneal
mouse 		405 mg/kg ARTODN 33,163,1975
DNA damage intraperitoneal
mouse 		160 mg/kg PCBPBS 6,101,1976
DNA repair other microorganisms 10 mg/plate BIZNAT 95,463,1976
unscheduled DNA synthesis human other cell types 4 mole/L PSSCBG 15,439,1984
unscheduled DNA synthesis human fibroblast 100 mg/L NTIS** PB80-133226
host-mediated assay mouse
Salmonella typhimurium 		50 mg/kg JPETAB 200,1,1977
mutation in microorganisms Escherichia coli 8,650 µg/plate (-enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Escherichia coli 1 mg/plate (+enzymatic activation step) NTIS** PB80-133226
mutation in microorganisms other microorganisms 4 mg/plate (-enzymatic activation step) CBINA8 22,297,1978
mutation in microorganisms Salmonella typhimurium 3,400 nmol/plate (+/-enzymatic activation step) JPETAB 200,1,1977
mutation in microorganisms Saccharomyes cerevisiae 5,000 ppm (+enzymatic activation step) NTIS** PB80-133226
mutation in microorganisms Schizosaccharomyces pombe 20 mmol/L (+/-enzymatic activation step) MUREAV 117,139,1983
micronucleus test intraperitoneal
mouse 		100 mg/kg MUREAV 471,37,2000
gene conversion and mitotic recombination Saccharomyes cerevisiae 5,000 ppm NTIS** PB80-133226
mutation in mammalian somatic cells mouse lymphocyte 80 mg/L NTIS** PB84-138973
morphological transform mouse embryo 3 mg/L PMRSDJ 5,659,1985
other mutation test systems human lymphocyte 20 mg/L MUREAV 300,135,1993
sister chromatid exchange hamster lung 20 mg/L MUREAV 88,307,1981
sister chromatid exchange hamster ovary 2 gm/L NTIS** PB84-138973
sister chromatid exchange human lymphocyte 20 mg/L MUREAV 300,135,1993
sister chromatid exchange intraperitoneal
mouse 		120 mg/kg MUREAV 300,135,1993
sex chromosome loss and nondisjunction intraperitoneal
mouse 		100 mg/kg MUREAV 471,31,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 60 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BIRUAA 13,238,1975
intraperitoneal
mouse 		lowest published toxic dose: 206 mg/kg (2-5 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) EESADV 13,216,1987
oral
guinea pig 		lowest published toxic dose: 600 mg/kg (36-53 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system 		ARTODN 59,30,1986
oral
guinea pig 		lowest published toxic dose: 600 mg/kg (36-53 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Other neonatal measures or effects 		ARTODN 59,30,1986
oral
hamster 		lowest published toxic dose: 2 gm/kg (7-11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis 		EVHPAZ 30,105,1979
oral
hamster 		lowest published toxic dose: 2 gm/kg (7-11 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) EVHPAZ 30,105,1979
oral
hamster 		lowest published toxic dose: 1,500 mg/kg (7-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 30,105,1979
oral
hamster 		lowest published toxic dose: 400 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death EVHPAZ 30,105,1979
oral
mouse 		lowest published toxic dose: 1,500 mg/kg (10-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 30,105,1979
oral
mouse 		lowest published toxic dose: 1,800 mg/kg (12-14 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) EVHPAZ 30,105,1979
oral
mouse 		lowest published toxic dose: 3 gm/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JPFCD2 21,207,1986
oral
mouse 		lowest published toxic dose: 4 gm/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		JPFCD2 21,207,1986
oral
rat 		lowest published toxic dose: 78,400 µg/kg (16-22 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic NUPOBT 17,135,1979
oral
rat 		lowest published toxic dose: 80 mg/kg (13 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		EVHPAZ 13,121,1976
oral
rat 		lowest published toxic dose: 80 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Homeostasis 		EVHPAZ 13,121,1976
oral
rat 		lowest published toxic dose: 1,450 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		EVHPAZ 13,133,1976
oral
rat 		lowest published toxic dose: 750 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 13,133,1976
oral
rat 		lowest published toxic dose: 2,200 µg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) GISAAA 38(8),21,1973
oral
rat 		lowest published toxic dose: 12,210 mg/kg (60 day male/14 day prior to copulation) Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		JESEDU 31,1141,1996
oral
rat 		lowest published toxic dose: 26,327 mg/kg (multigeneration) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic 		REPTED 12,619,1998
oral
rabbit 		lowest published toxic dose: 700 mg/kg (2-15 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Maternal- fetal exchange 		RPTOAN 38,84,1975
unreported route
guinea pig 		lowest published toxic dose: 375 mg/kg (42-44 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NEREDZ 19,569,1994
unreported route
mouse 		lowest published toxic dose: 4,200 mg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 21,35A,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 183 mg/kg/6 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors 		ARGEAR 41,311,1973
oral
rat 		lowest published toxic dose: 186 mg/kg/6 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors 		ARGEAR 41,311,1973
oral
rat 		lowest published toxic dose: 11.250 mg/kg/75 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria EXONC* 14,36,1992
skin
rat 		lowest published toxic dose: 1,950 mg/kg/22 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		ERNFA7 16,515,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 1,710 µg/m3/90 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase BJIMAG 43,414,1986
inhalation
rat 		lethal concentration (50 percent kill): 1,300 mg/m3 N/R ARGEAR 48,112,1978
intramuscular
rat 		lethal dose (50 percent kill): 395 mg/kg Cardiac: Other changes

Liver: Other changes

Blood: Hemorrhage 		ARTODN 41,3,1978
intramuscular
rabbit 		lowest published lethal dose: 500 mg/kg Vascular: Other changes

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage 		MDWTAG 35,479,1979
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 300 mg/kg N/R AMIHAB 11,53,1955
intraperitoneal
hamster 		lethal dose (50 percent kill): 1 gm/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 196 mg/kg N/R TXAPA9 2,495,1960
intraperitoneal
rat 		lethal dose (50 percent kill): 160 mg/kg N/R APCRAW 4,117,1961
intraperitoneal
rabbit 		lethal dose (50 percent kill): 60 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		AJOPAA 53,512,1962
intravenous
dog 		lethal dose (50 percent kill): 150 mg/kg Cardiac: Other changes

Liver: Other changes

Blood: Hemorrhage 		ARTODN 41,3,1978
intravenous
mouse 		lethal dose (50 percent kill): 290 mg/kg Cardiac: Other changes

Liver: Other changes

Blood: Hemorrhage 		ARTODN 41,3,1978
oral
wild bird 		lethal dose (50 percent kill): 37 mg/kg N/R AECTCV 12,355,1983
oral
cat 		lethal dose (50 percent kill): 97 mg/kg N/R 85GMAT -,60,1982
oral
chicken 		lethal dose (50 percent kill): 75 mg/kg N/R EQSFAP 3,173,1974
oral
chicken 		lowest published toxic dose: 80 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOLED5 136,143,2002
oral
dog 		lethal dose (50 percent kill): 400 mg/kg Cardiac: Other changes

Liver: Other changes

Blood: Hemorrhage 		ARTODN 41,3,1978
oral
guinea pig 		lowest published lethal dose: 420 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		BUMMAB 9,7,1955
oral
monkey 		lethal dose : >1 gm/kg Spinal Cord: Other degenerative changes

Gastrointestinal: Other changes

Musculoskeletal: Other changes 		JOUOD4 5(Suppl),125,1983
oral
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R SPEADM 78-1,26,1978
oral
quail 		lethal dose (50 percent kill): 73,110 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea 		HOEKAN 24,35,1974
oral
rat 		lethal dose (50 percent kill): 450 mg/kg N/R USXXAM #5006545
oral
rat 		lethal dose (50 percent kill): 882.7 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase FATOAO 53,64,1990
oral
rat 		lowest published toxic dose: 3 mg/kg Behavioral: Alteration of operant conditioning EURNE* 14,285,2003
oral
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Change in psychophysiological tests PSCHDL 172,375,2004
oral
rabbit 		lethal dose (50 percent kill): 160 mg/kg N/R ARZNAD 31,555,1981
oral
woman 		lowest published toxic dose: 1,364 µL/kg Autonomic Nervous System: Ganglion blocker

Behavioral: General anesthetic

Behavioral: Sleep 		RISHDJ 21,993,1981
oral
woman 		lowest published toxic dose: 1 mL/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Muscle weakness

Behavioral: Coma 		JOUOD4 5(Suppl),125,1983
oral
woman 		lowest published toxic dose: 1,200 µL/kg Spinal Cord: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Coma 		JOUOD4 5(Suppl),125,1983
oral
woman 		lowest published toxic dose: 240 mg/kg Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Coma 		JOUOD4 5(Suppl),125,1983
subcutaneous
chicken 		lethal dose (50 percent kill): 125 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) BCPCA6 12,1377,1963
subcutaneous
dog 		lethal dose (50 percent kill): 269 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Other changes 		RCCRDT 7(1),23,1977
subcutaneous
mouse 		lethal dose (50 percent kill): 267 mg/kg N/R ARZNAD 31,555,1981
subcutaneous
rat 		lethal dose (50 percent kill): 400 mg/kg N/R JEENAI 50,356,1957
skin
mammal (species unspecified) 		lethal dose (50 percent kill): >2,800 mg/kg N/R ARTODN 41,3,1978
skin
mouse 		lethal dose (50 percent kill): 1,710 mg/kg N/R YKYUA6 37,597,1986
skin
rat 		lethal dose (50 percent kill): 2 gm/kg N/R ARGEAR 48,112,1978
skin
rabbit 		lethal dose : >1,500 mg/kg Skin: After systemic exposure: Dermatitis, irritative

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GTPZAB 8(10),54,1964
unreported route
cat 		lethal dose (50 percent kill): 98 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Acute pulmonary edema 		RPTOAN 50,61,1987
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 295 mg/kg N/R GISAAA 38(8),101,1973
unreported route
mouse 		lethal dose (50 percent kill): 445 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase PCJOAU 3,508,1969
unreported route
rat 		lethal dose (50 percent kill): 550 mg/kg N/R GTPZAB 26(6),21,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 59 mg/m3/14 hour/80 day- intermittent Vascular: Regional or general arteriolar or venous dilation

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA 32(12),13,1967
inhalation
rat 		lowest published toxic concentration: 2 mg/m3/4 hour/17 week- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GTPZAB 8(10),54,1964
intramuscular
rat 		lowest published toxic dose: 2,000 mg/kg/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field FATOAO 50,97,1987
intraperitoneal
rat 		lowest published toxic dose: 3 gm/kg/15 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve ARTODN 52,167,1983
intraperitoneal
rat 		lowest published toxic dose: 6 gm/kg/60 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 11,53,1955
oral
dog 		lowest published toxic dose: 1,050 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 1,1,1959
oral
mouse 		lowest published toxic dose: 2,100 mg/kg/14 day- continuous Liver: Changes in liver weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ATDAEI 1,21,1990
oral
rat 		lowest published toxic dose: 672 mg/kg/90 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOLED5 1000(Suppl 1),141,1980
oral
rat 		lowest published toxic dose: 780 mg/kg/10 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		GISAAA 49(5),80,1984
oral
rat 		lowest published toxic dose: 562 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		GISAAA 29(5),30,1964
subcutaneous
chicken 		lowest published toxic dose: 300 mg/kg/5 day- intermittent Brain and Coverings: Demyelination

Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		EESADV 3,245,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 ( intermittent) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,207,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,207,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
CRTXB2 3,289,1975
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
MZUZA8 (8),90,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,154,1998
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0248;
Number of Industries 1;
Total Number of Facilities 473;
Number of Occupations 1;
Total Number of Employees Exposed 9,450
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0248;
Number of Industries 1;
Total Number of Facilities 19;
Number of Occupations 1;
Total Number of Employees Exposed 338;
Total Number of Female Employees Exposed 131


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
Used as an agricultural and forest insecticide
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
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Used as an agricultural and forest insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 66758-31-4
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