The Registry of Toxic Effects of Chemical Substances
Phosphine, triphenyl - |
UPDATE: October 1997 | MW: 262.30 | MF: C18H15P |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
500 mg/24 hour
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mild
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85JCAE -,1114,1986
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skin | rabbit
500 mg/24 hour
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mild
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85JCAE -,1114,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lethal concentration (50 percent kill): 1,135 ppm/4 hour
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Eye: Lacrimation | Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAM* -,-,1969
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intramuscular | rat
lethal dose (50 percent kill): 1,500 mg/kg
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Behavioral: Convulsions or effect on seizure threshold
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EPASR* 8EHQ-0384-0014
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oral | chicken
lowest published lethal dose: 9 gm/kg
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Behavioral: Convulsions or effect on seizure threshold
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EPASR* 8EHQ-0384-0014
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oral | dog
lethal dose (50 percent kill): >500 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0570648
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oral | mouse
lethal dose (50 percent kill): 1 gm/kg
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Behavioral: Convulsions or effect on seizure threshold
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EPASR* 8EHQ-0384-0014
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oral | rat
lethal dose (50 percent kill): 700 mg/kg
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Behavioral: Convulsions or effect on seizure threshold
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EPASR* 8EHQ-0384-0014
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subcutaneous | mouse
lethal dose (50 percent kill): 3 gm/kg
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Behavioral: Convulsions or effect on seizure threshold
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EPASR* 8EHQ-0384-0014
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skin | rabbit
lethal dose (50 percent kill): >5 gm/kg
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N/R
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TXAPA9 28,313,1974
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
inhalation | dog
lowest published toxic concentration: 94,500 µg/m3/6 hour/4 week- intermittent
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Behavioral: Change in motor activity (specific assay)
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NTIS** OTS0570648
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oral | dog
lowest published toxic dose: 950 mg/kg/14 day- intermittent
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Spinal Cord: Other degenerative changes | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold
NTIS** OTS0570648
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oral | dog
lowest published toxic dose: 525 mg/kg/21 day- intermittent
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Spinal Cord: Demyelination | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia
NTIS** OTS0570648
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X4096; |
Number of Industries 13; Total Number of Facilities 268; Number of Occupations 18; Total Number of Employees Exposed 14,258; Total Number of Female Employees Exposed 1,373 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
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FEREAC 47,26992,82
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AIHAM*
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Annual Meeting of American Industrial Hygiene Association. (Akron, OH) For publisher
information, see AIHAAP.
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EPASR*
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United States Environmental Protection Agency, Office of Pesticides and Toxic Substances.
(U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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TXAPA9
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Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
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