The Registry of Toxic Effects of Chemical Substances

Phosphine

RTECS #: SY7525000

CAS #: 7803-51-2

UPDATE: November 2004 MW: 34.00 MF: H3P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Fosforowodor (Polish)
  2. Gas - Ex - B
  3. Hydrogen phosphide
  4. Phosphine (ACGIH:OSHA)
  1. RCRA waste number P096
  2. Phosphorus hydride
  3. Phosphorus trihydride
  4. Phosphorwasserstoff (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 1,400 ng/L SCIEAS 246,251,1989
micronucleus test inhalation
mouse 		5 ppm/6 hour/13 week- intermittent EMMUEG 24,81,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 70 mg/m3/2 hour N/R VCVN5* -,66,1993
inhalation
guinea pig 		lowest published lethal concentration: 139 mg/m3/4 hour N/R VCVN5* -,66,1993
inhalation
human 		lowest published lethal concentration: 1,000 ppm/5 minute N/R TABIA2 3,231,1933
inhalation
human 		lowest published toxic concentration: 2 mg/m3 Olfaction: Change in sensation of smell VCVN5* -,67,1993
inhalation
human 		lowest published lethal concentration: 10 mg/m3 Olfaction: Change in sensation of smell VCVN5* -,67,1993
inhalation
mammal (species unspecified) 		lowest published lethal concentration: 1,000 ppm/5 minute N/R AEPPAE 138,65,1928
inhalation
man 		lowest published toxic concentration: 2.7 ppm/20 minute Behavioral: Headache

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Hypermotility, diarrhea 		CTOXAO 39,165,2001
inhalation
mouse 		lowest published lethal concentration: 380 mg/m3/2 hour N/R 85GMAT -,75,1982
inhalation
mouse 		lowest published lethal concentration: 380 mg/m3/1 hour N/R VCVN5* -,66,1993
inhalation
mouse 		lowest published lethal concentration: 760 mg/m3/35 minute N/R VCVN5* -,66,1993
inhalation
rat 		lethal concentration (50 percent kill): 11 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 36,452,1975
inhalation
rat 		lowest published lethal concentration: 140 mg/m3/4 hour N/R VCVN5* -,66,1993
inhalation
rabbit 		lowest published lethal concentration: 2,500 ppm/20 minute N/R AEXPBL 27,314,1890
inhalation
rabbit 		lowest published lethal concentration: 139 mg/m3/4 hour N/R VCVN5* -,66,1993
inhalation
woman 		lowest published toxic concentration: 2.7 ppm/20 minute Behavioral: Headache

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Hypermotility, diarrhea 		JTCTDW 39,165,2001
intraperitoneal
rat 		lowest published toxic dose: 4 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins 		TXCYAC 179,1,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 14 mg/m3/7 hour/2 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,67,1989
inhalation
mouse 		lowest published toxic concentration: 10 ppm/4 hour/4 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		INHTE5 7,225,1995
inhalation
mouse 		lowest published toxic concentration: 5 ppm/4 hour/2 week- intermittent Cardiac: Changes in heart weight

Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		INHTE5 7,225,1995
inhalation
mouse 		lowest published toxic concentration: 5 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in bladder weight 		JOCHFV 38,36,1996
inhalation
rat 		lowest published toxic concentration: 200 µg/m3/24 hour/6 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		GISAAA 49(1),13,1984
inhalation
rat 		lowest published toxic concentration: 3,100 ppb/6 hour/13 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count 		INHTE5 5,223,1993
inhalation
rat 		lowest published toxic concentration: 10 ppm/4 hour/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field INHTE5 7,225,1995
inhalation
rat 		lowest published toxic concentration: 5 ppm/4 hour/2 week- intermittent Cardiac: Changes in heart weight

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight 		INHTE5 7,225,1995
inhalation
rabbit 		lowest published toxic concentration: 14 mg/m3/7 hour/2 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,67,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.3 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.3 ppm;short term exposure limit 1 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 1 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
NTIS** AD778-725


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.3 ppm (0.4 mg/m3) DTLVS* 3,209,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.3 ppm (0.4 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.3 ppm (0.4 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.3 ppm (0.4 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.3 ppm (0.4 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.3 ppm (0.4 mg/m3), short term exposure limit 1 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.15 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.3 ppm (0.42 mg/m3), short term exposure limit 1 ppm (1.4 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.15 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.15 mg/m3), short term exposure limit 0.3 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.13 mg/m3), VLE 0.3 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.15 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.4 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.15 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.8 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.3 ppm (0.4 mg/m3), KTV 1 ppm (1.4 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.15 mg/m3), KZG- week 0.2 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.3 ppm ( intermittent0.42 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHINE-air 10 hour time-weighted average 0.3 ppm;
short term exposure limit 1.0 ppm 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fumigant, a doping agent for electronic components, and in chemical synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phosphine, 6002
OSHA ANALYTICAL METHOD #ID180


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JOCHFV Journal of Occupational Health. (Japan Society for Occupational Health, 1-29-8 Shinjuku, Shinjuku-ku, Tokyo, 160, Japan) V.38- 1996-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63. Discontinued.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as a fumigant, a doping agent for electronic components, and in chemical synthesis

NIOSH PROFILE (PETROCHEMICAL PLANTS), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

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