The Registry of Toxic Effects of Chemical Substances

p - Phenylenediamine, N - phenyl -

RTECS #: ST3150000

CAS #: 101-54-2

UPDATE: July 2002 MW: 184.26 MF: C12H12N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. N - Phenyl - p - aminoaniline
  2. Acna Black DF Base
  3. p - Aminodifenylamin (Czech)
  4. p - Aminodiphenylamine
  5. 4 - Aminodiphenylamine
  6. p - Anilinoaniline
  7. Azosalt R
  8. 1,4 - Benzenediamine, N - phenyl - (9CI)
  9. C.I. Azoic Diazo Component 22
  10. C.I. Developer 15
  11. C.I. Oxidation Base 2
  12. C.I. 37240
  13. C.I. 76085
  14. Diphenylamine, p - amino -
  15. Diphenylamine, 4 - amino -
  1. Diphenyl Black
  2. Fast Blue R Salt
  3. N - Fenyl - p - fenylendiamin (Czech)
  4. Luxan Black R
  5. Naphthoelan Navy Blue
  6. NCI - C02233
  7. Oxy Acid Black Base
  8. Peltol BR
  9. Peltol BR II
  10. N - Phenyl - 1,4 - benzenediamine
  11. N - Phenyl - p - phenylenediamine
  12. Rodol Gray B base
  13. p - Semidine
  14. Variamine Blue Salt RT


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,481,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 150 µg/plate (-enzymatic activation step) ESKHA5 (94),28,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TOXID9 12,103,1992
oral
rat 		lowest published toxic dose: 1,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TOXID9 12,103,1992
oral
rat 		lowest published toxic dose: 1,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TOXID9 12,103,1992


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
cat 		lowest published lethal dose: 100 mg/kg Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia 		JACTDZ 13,374,1994
oral
mouse 		lethal dose (50 percent kill): 244 mg/kg Blood: Hemorrhage

Nutritional and Gross Metabolic: Body temperature decrease 		TPKVAL 8,126,1966
oral
rat 		lethal dose (50 percent kill): 464 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
oral
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R JACTDZ 13,374,1994
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg Olfaction: Other olfaction effects

Eye: Other eye effects

Behavioral: Food intake (animal) 		ATDAEI 1,63,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 13,500 mg/kg/90 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		VHTODE 28,219,1986
oral
rat 		lowest published toxic dose: 1,500 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 12,103,1992
oral
rat 		lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 12,103,1992
oral
rat 		lowest published toxic dose: 1,500 mg/kg/10 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 12,103,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83649;
Number of Industries 4;
Total Number of Facilities 211;
Number of Occupations 20;
Total Number of Employees Exposed 7,379
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83649;
Number of Industries 4;
Total Number of Facilities 63;
Number of Occupations 11;
Total Number of Employees Exposed 4,356;
Total Number of Female Employees Exposed 530


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a dye, pigment and printing ink
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-82,1978


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as a dye, pigment and printing ink

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 101-54-2
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