The Registry of Toxic Effects of Chemical Substances

p - Phenylenediamine, 2 - nitro -

RTECS #: ST3000000

CAS #: 5307-14-2

UPDATE: May 2003 MW: 153.16 MF: C6H7N3O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 4 - Amino - 2 - nitroaniline
  2. C.I. 76070
  3. C.I. Oxidation Base 22
  4. 1,4 - Diamino - 2 - nitrobenzene
  5. 1,4 - Diaminonitrobenzol (German)
  6. Durafur Brown 2R
  7. Dye GS
  8. Fouramine 2R
  9. Fourrine 36
  10. Fourrine Brown 2R
  11. NCI - C02222
  1. 2 - Nitro - 4 - aminoaniline
  2. 2 - Nitro - 1,4 - benzenediamine
  3. 2 - Nitro - 1,4 - diaminobenzene
  4. o - Nitro - p - phenylenediamine
  5. 2 - Nitro - 1,4 - phenylenediamine
  6. Nitro - p - phenylenediamine
  7. 2 - Nitro - p - phenylenediamine
  8. Oxidation Base 22
  9. Ursol Brown RR
  10. Zoba Brown RR


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium 		200 µg/kg MUREAV 66,241,1979
cytogenetic analysis hamster ovary 123 mg/L EMMUEG 27,67,1996
cytogenetic analysis hamster fibroblast 8 mg/L/48 hour MUREAV 48,337,1977
cytogenetic analysis hamster other cell types 10 µmol/L/24 hour NATUAS 260,368,1976
cytogenetic analysis hamster other cell types 10 µmol/L NATUAS 260,368,1976
cytogenetic analysis hamster lung 10 mg/L ATSUDG 4,41,1980
cytogenetic analysis human lymphocyte 50 mg/L/24 hour NATUAS 255,506,1975
DNA damage mouse lymphocyte 5,970 µmol/L MUREAV 203,155,1988
DNA repair Escherichia coli 4,170 µmol/L MUREAV 272,145,1992
unscheduled DNA synthesis human HeLa cell 100 nmol/L CNREA8 38,2621,1978
unscheduled DNA synthesis rat liver 100 mg/L MUREAV 97,359,1982
host-mediated assay mouse
Escherichia coli 		160 mg/kg MUREAV 272,161,1992
mutation in microorganisms Escherichia coli 333 µg/plate (-enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms Escherichia coli 100 µg/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms mouse lymphocyte 5 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms Salmonella typhimurium 5 µg/plate (+enzymatic activation step) NATUAS 255,506,1975
mutation in microorganisms Salmonella typhimurium 3,300 ng/plate (-enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
micronucleus test intraperitoneal
mouse 		400 mg/kg/24 hour- continuous CYTOAN 57,149,1992
mutation in mammalian somatic cells mouse lymphocyte 25 mg/L JEPTDQ 1(1),87,1977
morphological transform hamster embryo 500 µg/L NCIMAV 58,243,1981
morphological transform mouse embryo 10 µmol/L/24 hour NATUAS 260,368,1976
morphological transform mouse other cell types 10 µmol/L NATUAS 260,368,1976
sister chromatid exchange hamster ovary 10 mg/L MUREAV 56,207,1977
sister chromatid exchange oral
hamster 		125 mg/kg BLFSBY 29B,613,1984
specific locus test hamster ovary 100 mg/L/9 day EMMUEG 16,260,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 1,600 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		TJADAB 19,37A,1979
subcutaneous
mouse 		lowest published toxic dose: 1,600 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 24,253,1981
subcutaneous
mouse 		lowest published toxic dose: 2,240 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Eye, ear 		TJADAB 24,253,1981
subcutaneous
mouse 		lowest published toxic dose: 1,280 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 24,253,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 288 gm/kg/78 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-169,1979
oral
mouse 		toxic dose : 144 gm/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-169,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 214 mg/kg N/R GPOLA4 26,109,1985
intraperitoneal
rat 		lethal dose (50 percent kill): 348 mg/kg N/R JTEHD6 2,657,1977
oral
rat 		lethal dose (50 percent kill): 2,100 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition JSCCA5 23,259,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 57,185,1993
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 16,73,1978
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 16,73,1978
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 57,185,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 57,185,1993
TOXICOLOGY REVIEW
JACTDZ 4(3),161,1985


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Skin, Suspected Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Skin, Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1644;
Number of Industries 1;
Total Number of Facilities 3,160;
Number of Occupations 1;
Total Number of Employees Exposed 29,422;
Total Number of Female Employees Exposed 23,531


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in dyeing furs, and as a dye intermediate in hair coloring products
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE FEREAC 47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse NCITR* NCI-TR-169,1979
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-169,1979


REFERENCES:

CODEN
REFERENCE
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GPOLA4 Genetica Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1960-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

Used in dyeing furs, and as a dye intermediate in hair coloring products

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

 Click Here for Additional Information about RTECS