The Registry of Toxic Effects of Chemical Substances

p - Phenylenediamine, N - isopropyl - N' - phenyl -

RTECS #: ST2650000

CAS #: 101-72-4

UPDATE: August 2004 MW: 226.35 MF: C15H18N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Nonox ZA
  2. Cyzone
  3. Elastozone 34
  4. N - Fenyl - N' - isopropyl - p - fenylendiamin (Czech)
  5. Flexzone 3C
  6. 4 - Isopropylaminodiphenylamine
  7. N - Isopropyl - N' - fenyl - p - fenylendiamin (Czech)
  1. N - Isopropyl - N' - phenyl - p - phenylenediamine
  2. 4010 NA
  3. NCI - C56304
  4. N - Phenyl - N' - isopropyl - p - phenylenediamine
  5. N - 2 - Propyl - N' - phenyl - p - phenylenediamine
  6. Santoflex 36


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,483,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 1,122 mg/kg N/R KOKABN 26,438,1977
oral
rat 		lethal dose (50 percent kill): 720 mg/kg N/R IPSTB3 3,93,1976
oral
rabbit 		lethal dose : >7,500 mg/kg N/R IPSTB3 3,93,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80314;
Number of Industries 5;
Total Number of Facilities 153;
Number of Occupations 11;
Total Number of Employees Exposed 1,686
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80314;
Number of Industries 3;
Total Number of Facilities 31;
Number of Occupations 9;
Total Number of Employees Exposed 4,130;
Total Number of Female Employees Exposed 478


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of plastics, resins, rubber and synthetic textiles
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8854;8EHQ-0892-8907
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9281
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
KOKABN Kobunshi Kako. Polymer Applications. (Kobunshi Kankokai, Chiekoin Maruta-machi Kundaru, Kamigyo-ku, Kyoto 602, Japan) V.13- 1964-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used in the manufacture of plastics, resins, rubber and synthetic textiles

RTECS Compound Description:
   Primary Irritant

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