The Registry of Toxic Effects of Chemical Substances
o - Phenylenediamine |
UPDATE: May 2004 | MW: 108.16 | MF: C6H8N2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster ovary | 187 mg/L | EMMUEG 27,67,1996 |
cytogenetic analysis | hamster lung | 1 mg/L | ATSUDG 4,41,1980 |
cytogenetic analysis | human lymphocyte | 10 mmol/L | MUREAV 421,83,1998 |
DNA damage | human lymphocyte | 15 mmol/L | MUREAV 421,83,1998 |
DNA inhibition | human HeLa cell | 7 mmol/L | CRNGDP 13,2389,1992 |
DNA inhibition |
oral mouse | 200 mg/kg | MUREAV 46,305,1977 |
unscheduled DNA synthesis | rat liver | 100 痠ol/L | ENMUDM 5,803,1983 |
mutation in microorganisms | Salmonella typhimurium | 1 gm/L (+enzymatic activation step) | JIMMBG 36,55,1980 |
mutation in microorganisms | Salmonella typhimurium | 1 痠ol/plate (-enzymatic activation step) | JTSCDR 7,61,1982 |
micronucleus test |
intraperitoneal guinea pig | 216 mg/kg/24 hour | ARTODN 43,249,1980 |
micronucleus test |
intraperitoneal hamster | 432 mg/kg/24 hour | ARTODN 43,249,1980 |
micronucleus test |
intraperitoneal mouse | 216 mg/kg/24 hour | ARTODN 43,249,1980 |
micronucleus test |
oral mouse | 216 mg/kg/24 hour | ARTODN 43,249,1980 |
other mutation test systems | Salmonella typhimurium | 140 mg/L | MUREAV 192,239,1987 |
phage inhibition capacity | Escherichia coli | 125 痢/well | MUREAV 260,349,1991 |
sister chromatid exchange | human lymphocyte | 10 mmol/L | MUREAV 421,83,1998 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mouse | lethal concentration (50 percent kill): >91 mg/m3/4 hour | N/R | 85INA8 6,1214,1991 |
inhalation rat | lethal concentration (50 percent kill): 1,873 mg/m3 |
Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Olfaction: Other olfaction effects Behavioral: Convulsions or effect on seizure threshold | GISAAA 51(1),73,1986 |
intraperitoneal mouse | lethal dose (50 percent kill): 245 mg/kg | N/R | NCISP* JAN1986 |
intraperitoneal rat | lethal dose (50 percent kill): 516 mg/kg | N/R | JTEHD6 2,657,1977 |
oral wild bird | lethal dose (50 percent kill): 133 mg/kg | N/R | AECTCV 12,355,1983 |
oral cat | lowest published lethal dose: 250 mg/kg | N/R | 85INA8 6,1214,1991 |
oral guinea pig | lethal dose (50 percent kill): 360 mg/kg | N/R | GISAAA 53(7),62,1988 |
oral mouse | lethal dose (50 percent kill): 366 mg/kg | N/R | GISAAA 53(7),62,1988 |
oral rat | lethal dose (50 percent kill): 510 mg/kg |
Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness | GTPZAB 32(9),50,1988 |
subcutaneous mouse | lethal dose (50 percent kill): 450 mg/kg | N/R | KJMSAH 13,175,1962 |
skin rat | lethal dose (50 percent kill): >5 gm/kg | N/R | 85INA8 6,1214,1991 |
skin rabbit | lowest published lethal dose: 1,500 mg/kg |
Behavioral: Ataxia Gastrointestinal: Changes in structure or function of salivary glands Kidney, Ureter, and Bladder: Hematuria | NTIS** OTS0571626 |
unreported route guinea pig | lethal dose (50 percent kill): 360 mg/kg |
Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Olfaction: Other olfaction effects Behavioral: Convulsions or effect on seizure threshold | GISAAA 51(1),73,1986 |
unreported route mouse | lethal dose (50 percent kill): 336 mg/kg | N/R | GISAAA 50(6),78,1985 |
unreported route rat | lethal dose (50 percent kill): 660 mg/kg |
Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Olfaction: Other olfaction effects Behavioral: Convulsions or effect on seizure threshold | GISAAA 51(1),73,1986 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 80 mg/m3/4 hour/10 day- continuous |
Lung, Thorax, or Respiration: Dyspnea Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0571513 |
skin rabbit | lowest published toxic dose: 3 gm/kg/2 week- intermittent |
Blood: Normocytic anemia Skin: After systemic exposure: Dermatitis, other Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0555823 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 0.1 mg/m3 | DTLVS* TLV/BEI,2003 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Confirmed Animal Carcinogen with Unknown | DTLVS* TLV/BEI,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - AUSTRIA | Carcinogen, JAN1999 | |
Occupational Exposure Limit - DENMARK | time-weighted average 0.1 mg/m3, JAN1999 | |
Occupational Exposure Limit - NORWAY | time-weighted average 0.1 mg/m3, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 0.1 mg/m3, Skin, Carcinogen, JAN1999 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X4334![]() Number of Industries 2; Total Number of Facilities 342; Number of Occupations 4; Total Number of Employees Exposed 3,076; Total Number of Female Employees Exposed 1,372 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; N crassa-aneuploidy | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
Used as dye, pesticide, pharmaceutical, rubber chemical intermediate | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
OSHA ANALYTICAL METHOD #87 |
REFERENCES: | |
CODEN |
REFERENCE |
85INA8 | "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 |
AECTCV | Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- |
ARTODN | Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- |
ATSUDG | Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- |
CRNGDP | Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
ENMUDM | Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. |
FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
JIMMBG | Journal of Immunological Methods. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1971- |
JTEHD6 | Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- |
JTSCDR | Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- |
KJMSAH | Kyushu Journal of Medical Science. (Fukuoka, Japan) V.6-15, 1955-64. Discontinued. |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NCISP* | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |