The Registry of Toxic Effects of Chemical Substances

o - Phenylenediamine

RTECS #: SS7875000

CAS #: 95-54-5

UPDATE: May 2004 MW: 108.16 MF: C6H8N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. NSC 5354
  2. 2 - Aminoaniline
  3. o - Benzenediamine
  4. 1,2 - Benzenediamine (9CI)
  5. C.I. 76010
  6. C.I. Oxidation Base 16
  7. o - Diaminobenzene
  8. EK 1700
  1. o - Fenylendiamin (Czech)
  2. 1,2 - Fenylendiamin (Czech)
  3. IK 3
  4. Orthamine
  5. SQ 15500
  6. o - Phenylenediamine (ACGIH)
  7. 1,2 - Phenylenediamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 187 mg/L EMMUEG 27,67,1996
cytogenetic analysis hamster lung 1 mg/L ATSUDG 4,41,1980
cytogenetic analysis human lymphocyte 10 mmol/L MUREAV 421,83,1998
DNA damage human lymphocyte 15 mmol/L MUREAV 421,83,1998
DNA inhibition human HeLa cell 7 mmol/L CRNGDP 13,2389,1992
DNA inhibition oral
mouse 		200 mg/kg MUREAV 46,305,1977
unscheduled DNA synthesis rat liver 100 µmol/L ENMUDM 5,803,1983
mutation in microorganisms Salmonella typhimurium 1 gm/L (+enzymatic activation step) JIMMBG 36,55,1980
mutation in microorganisms Salmonella typhimurium 1 µmol/plate (-enzymatic activation step) JTSCDR 7,61,1982
micronucleus test intraperitoneal
guinea pig 		216 mg/kg/24 hour ARTODN 43,249,1980
micronucleus test intraperitoneal
hamster 		432 mg/kg/24 hour ARTODN 43,249,1980
micronucleus test intraperitoneal
mouse 		216 mg/kg/24 hour ARTODN 43,249,1980
micronucleus test oral
mouse 		216 mg/kg/24 hour ARTODN 43,249,1980
other mutation test systems Salmonella typhimurium 140 mg/L MUREAV 192,239,1987
phage inhibition capacity Escherichia coli 125 µg/well MUREAV 260,349,1991
sister chromatid exchange human lymphocyte 10 mmol/L MUREAV 421,83,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): >91 mg/m3/4 hour N/R 85INA8 6,1214,1991
inhalation
rat 		lethal concentration (50 percent kill): 1,873 mg/m3 Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold 		GISAAA 51(1),73,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 245 mg/kg N/R NCISP* JAN1986
intraperitoneal
rat 		lethal dose (50 percent kill): 516 mg/kg N/R JTEHD6 2,657,1977
oral
wild bird 		lethal dose (50 percent kill): 133 mg/kg N/R AECTCV 12,355,1983
oral
cat 		lowest published lethal dose: 250 mg/kg N/R 85INA8 6,1214,1991
oral
guinea pig 		lethal dose (50 percent kill): 360 mg/kg N/R GISAAA 53(7),62,1988
oral
mouse 		lethal dose (50 percent kill): 366 mg/kg N/R GISAAA 53(7),62,1988
oral
rat 		lethal dose (50 percent kill): 510 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness 		GTPZAB 32(9),50,1988
subcutaneous
mouse 		lethal dose (50 percent kill): 450 mg/kg N/R KJMSAH 13,175,1962
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R 85INA8 6,1214,1991
skin
rabbit 		lowest published lethal dose: 1,500 mg/kg Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Hematuria 		NTIS** OTS0571626
unreported route
guinea pig 		lethal dose (50 percent kill): 360 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold 		GISAAA 51(1),73,1986
unreported route
mouse 		lethal dose (50 percent kill): 336 mg/kg N/R GISAAA 50(6),78,1985
unreported route
rat 		lethal dose (50 percent kill): 660 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold 		GISAAA 51(1),73,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 80 mg/m3/4 hour/10 day- continuous Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0571513
skin
rabbit 		lowest published toxic dose: 3 gm/kg/2 week- intermittent Blood: Normocytic anemia

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555823


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4334;
Number of Industries 2;
Total Number of Facilities 342;
Number of Occupations 4;
Total Number of Employees Exposed 3,076;
Total Number of Female Employees Exposed 1,372


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; N crassa-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as dye, pesticide, pharmaceutical, rubber chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #87


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIMMBG Journal of Immunological Methods. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1971-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
KJMSAH Kyushu Journal of Medical Science. (Fukuoka, Japan) V.6-15, 1955-64. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as dye, pesticide, pharmaceutical, rubber chemical intermediate

NIOSH PROFILE (AMINES, PRIMARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Mutagen

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