The Registry of Toxic Effects of Chemical Substances

m - Phenylenediamine

RTECS #: SS7700000

CAS #: 108-45-2

UPDATE: November 2004 MW: 108.16 MF: C6H8N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. m - Aminoaline
  2. 3 - Aminoaniline
  3. APCO 2330
  4. m - Benzenediamine
  5. 1,3 - Benzenediamine (9CI)
  6. C.I. 76025
  7. Developer 11
  8. Developer C
  9. Developer H
  10. Developer M
  1. m - Diaminobenzene
  2. 1,3 - Diaminobenzene
  3. Direct Brown BR
  4. Direct Brown GG
  5. m - Fenylendiamin (Czech)
  6. Metaphenylenediamine
  7. Phenylenediamine
  8. 1,3 - Phenylenediamine
  9. m - Phenylenediamine (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL severe NTIS** OTS0559504


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium 		240 mg/kg MUREAV 138,137,1984
cytogenetic analysis hamster lung 12 mg/L GMCRDC 27,95,1981
DNA inhibition oral
mouse 		200 mg/kg MUREAV 46,305,1977
mutation in microorganisms Salmonella typhimurium 250 µg/plate (+enzymatic activation step) JACTDZ 2(4),325,1983
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) BCPCA6 26,729,1977
mutation in microorganisms Salmonella typhimurium 1 nmol/plate/20 minute EMMUEG 38,268,2001
mutation in microorganisms Salmonella typhimurium 3.3 mmol/L/20 minute EMMUEG 38,80,2001
micronucleus test intraperitoneal
mouse 		400 mg/kg/24 hour- continuous CYTOAN 57,149,1992
mutation in mammalian somatic cells mouse lymphocyte 50 mg/L JEPTDQ 1(1),87,1977
morphological transform hamster embryo 50 µg/L NCIMAV 58,243,1981
phage inhibition capacity Escherichia coli 175 µg/well MUREAV 260,349,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 375 mg/kg (30 day male) Reproductive: Effects on embryo or fetus: Fetal death SheCW# 25MAR1977
oral
rat 		lowest published toxic dose: 900 mg/kg (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		NTIS** OTS0555025


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 1,485 mg/kg/47 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		KJMSAH 13,175,1962


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 400 mg/kg N/R RBPMAZ 22,1,1952
intraperitoneal
rat 		lethal dose (50 percent kill): 283 mg/kg N/R JTEHD6 2,657,1977
intravenous
dog 		lowest published lethal dose: 17 mg/kg N/R JIDHAN 4,386,1923
oral
wild bird 		lethal dose (50 percent kill): 562 mg/kg N/R AECTCV 12,355,1983
oral
cat 		lowest published lethal dose: 300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		JIDHAN 4,386,1923
oral
guinea pig 		lethal dose (50 percent kill): 450 mg/kg N/R GISAAA 53(7),62,1988
oral
mouse 		lethal dose (50 percent kill): 67,700 µg/kg N/R GISAAA 53(7),62,1988
oral
rat 		lethal dose (50 percent kill): 280 mg/kg N/R GISAAA 53(7),62,1988
oral
rabbit 		lethal dose (50 percent kill): 437 mg/kg N/R GISAAA 53(7),62,1988
subcutaneous
dog 		lowest published lethal dose: 100 mg/kg N/R NTIS** OTS0555804
subcutaneous
mouse 		lethal dose (50 percent kill): 90 mg/kg N/R KJMSAH 13,175,1962
subcutaneous
rat 		lowest published lethal dose: 80 mg/kg N/R NTIS** OTS0555804
subcutaneous
rabbit 		lowest published lethal dose: 200 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		JIDHAN 4,386,1923
skin
rabbit 		lowest published lethal dose: 1,500 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition 		NTIS** OTS0555804
unreported route
guinea pig 		lethal dose (50 percent kill): 450 mg/kg N/R GTPZAB 31(8),46,1987
unreported route
mouse 		lethal dose (50 percent kill): 65,300 µg/kg N/R GTPZAB 31(8),46,1987
unreported route
rat 		lethal dose (50 percent kill): 351 mg/kg N/R GTPZAB 31(8),46,1987
unreported route
rabbit 		lethal dose (50 percent kill): 438 mg/kg N/R GTPZAB 31(8),46,1987


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 900 mg/kg/2 week- intermittent Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Other changes 		NTIS** OTS0555804


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 16,111,1978
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 16,111,1978
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Skin, Suspected Carcinogen, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY Skin, Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83124;
Number of Industries 18;
Total Number of Facilities 1,364;
Number of Occupations 21;
Total Number of Employees Exposed 12,590
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83124;
Number of Industries 12;
Total Number of Facilities 3,739;
Number of Occupations 18;
Total Number of Employees Exposed 40,632;
Total Number of Female Employees Exposed 32,320


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used for the production of various dyes, as a curing agent for epoxy resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #87


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KJMSAH Kyushu Journal of Medical Science. (Fukuoka, Japan) V.6-15, 1955-64. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale. (Brussels, Belgium) V.18-31, 1947-65. For publisher information, see PTEUA6.
SheCW# Personal Communication from C.W. Sheu, Genetic Toxicology Branch, FDA, Mar. 25, 1977

Used for the production of various dyes, as a curing agent for epoxy resins

NIOSH PROFILE (AMINES, PRIMARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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