The Registry of Toxic Effects of Chemical Substances

Phenothiazine

RTECS #: SN5075000

CAS #: 92-84-2

UPDATE: November 2004 MW: 199.28 MF: C12H9NS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. AFI - Tiazin
  2. Agrazine
  3. Antiverm
  4. Biverm
  5. Contaverm
  6. Dibenzothiazine
  7. Dibenzo - 1,4 - thiazine
  8. ENT 38
  9. Feeno
  10. Fenothiazine (Dutch)
  11. Fenotiazina (Italian)
  12. Fenoverm
  13. Fentiazin
  14. Helmetina
  15. Lethelmin
  16. Nemazene
  17. Orimon
  1. Padophene
  2. Penthazine
  3. Phenegic
  4. Phenosan
  5. Phenoverm
  6. Phenovis
  7. Phenoxur
  8. Phenthiazine
  9. Reconox
  10. Souframine
  11. Thiodifenylamine (Dutch)
  12. Thiodiphenylamin (German)
  13. Thiodiphenylamine
  14. Tiodifenilamina (Italian)
  15. Wurm - thional
  16. XL - 50
  17. Phenothiazine (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,250 mg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AJANA2 110,29,1962


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 178 mg/kg N/R CSLNX* NX#00586
oral
child 		lowest published lethal dose: 425 mg/kg/5 day Behavioral: Headache

Liver: Jaundice, other or unclassified

Blood: Normocytic anemia 		LANCAO 242,86,1942
oral
cattle 		lethal dose (50 percent kill): 500 mg/kg N/R 85JCAE -,1104,1986
oral
mouse 		lethal dose (50 percent kill): 5 gm/kg Behavioral: Antipsychotic DNEUD5 7,45,1980
oral
rabbit 		lethal dose (50 percent kill): 4 gm/kg N/R 85JCAE -,1104,1986
unreported route
wild bird 		lowest published lethal dose: 500 mg/kg N/R JACSAT 66,888,1944


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
PLMJAP 6,160,1975
TOXICOLOGY REVIEW
CLCHAU 19,361,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,198,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 (skin) DTLVS* 3,204,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENOTHIAZINE-air 10 hour time-weighted average 5 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84116;
Number of Industries 5;
Total Number of Facilities 175;
Number of Occupations 15;
Total Number of Employees Exposed 5,639
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84116;
Number of Industries 54;
Total Number of Facilities 5,473;
Number of Occupations 68;
Total Number of Employees Exposed 88,048;
Total Number of Female Employees Exposed 8,791


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pesticide and as a base for the manufacture of tranquilizers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91.
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as a pesticide and as a base for the manufacture of tranquilizers

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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