The Registry of Toxic Effects of Chemical Substances
Phenol, 2,4,6 - trichloro - |
UPDATE: May 2005 | MW: 197.44 | MF: C6H3Cl3O |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
250 µg/24 hour
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severe
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85JCAE -,525,1986
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skin | rabbit
20 mg/24 hour
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moderate
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85JCAE -,525,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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cytogenetic analysis
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hamster
ovary
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400 mg/L
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MUREAV 303,101,1993
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cytogenetic analysis
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hamster
lung
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500 mg/L
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MUREAV 303,101,1993
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DNA damage
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human
Ascites tumor
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50 mg/L/2 hour
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FCTOD7 42,1323,2004
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DNA damage
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other microorganisms
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500 µmol/L
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CBINA8 69,333,1989
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mutation in microorganisms
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Salmonella typhimurium
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10 µg/plate (-enzymatic activation step)
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TECSDY 14,143,1987
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mutation in microorganisms
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Saccharomyes cerevisiae
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400 mg/L (-enzymatic activation step)
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EVSRBT 12,325,1978
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micronucleus test
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hamster
lung
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30 mg/L
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MUREAV 280,175,1992
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mutation in mammalian somatic cells
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hamster
lung
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20 mg/L
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CMSHAF 14,1617,1985
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mutation in mammalian somatic cells
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mouse
lymphocyte
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80 mg/L
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EMMUEG 12,85,1988
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other mutation test systems
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hamster
lung
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100 mg/L
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MUREAV 303,101,1993
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sex chromosome loss and nondisjunction
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hamster
lung
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30 mg/L
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MUREAV 280,175,1992
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specific locus test
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intraperitoneal | mouse
50 mg/kg
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EVSRBT 12,325,1978
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 12,500 mg/kg (2 week prior to copulation/1-21 day pregnant)
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Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
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FAATDF 6,233,1986
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | mouse
lowest published toxic dose: 441 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Liver: Tumors
NCITR* NCI-TR-155,1979
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oral | mouse
toxic dose : 882 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Liver: Tumors
NCITR* NCI-TR-155,1979
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oral | rat
lowest published toxic dose: 185 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Blood: Leukemia Blood: Lymphoma including Hodgkin's disease
NCITR* NCI-TR-155,1979
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oral | rat
toxic dose : 374 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Blood: Leukemia Blood: Lymphoma including Hodgkin's disease
NCITR* NCI-TR-155,1979
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | mouse
lethal dose (50 percent kill): 276 mg/kg
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N/R
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VCVGK* -,245,1994
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intraperitoneal | rat
lethal dose (50 percent kill): 276 mg/kg
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Behavioral: Tremor | Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
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oral | guinea pig
lethal dose (50 percent kill): 1 gm/kg
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N/R
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FMCHA2 -,C310,1991
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oral | mammal (species unspecified)
lethal dose (50 percent kill): 454 mg/kg
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N/R
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GISAAA 45(10),16,1980
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oral | mouse
lethal dose (50 percent kill): 770 mg/kg
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N/R
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VCVGK* -,245,1994
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oral | rat
lethal dose (50 percent kill): 820 mg/kg
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N/R
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VCVGK* -,245,1994
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skin | mammal (species unspecified)
lethal dose (50 percent kill): 700 mg/kg
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N/R
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GISAAA 45(10),16,1980
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | human
lowest published toxic concentration: 3 mg/m3/3 year- intermittent
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Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Lung, Thorax, or Respiration: Other changes
VCVGK* -,247,1994
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oral | rat
lowest published toxic dose: 21,600 mg/kg/90 day- intermittent
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Liver: Changes in liver weight | Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JACTDZ 9(5),497,1990
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review
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Human Limited Evidence
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IMEMDT 41,319,1986
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International Agency for Research on Cancer (IARC) Cancer Review
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Animal Sufficient Evidence
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IMSUDL 7,154,1987
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International Agency for Research on Cancer (IARC) Cancer Review
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Animal Limited Evidence
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IMEMDT 71,769,1999
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International Agency for Research on Cancer (IARC) Cancer Review
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Animal Inadequate Evidence
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IMEMDT 20,349,1979
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 84393; | Number of Industries 1; Total Number of Facilities 14; Number of Occupations 2; Total Number of Employees Exposed 112
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 84393; |
Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 851; Total Number of Female Employees Exposed 187 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/181545/AS)
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EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; S cerevisiae-forward mutation
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EPA GENETOX PROGRAM 1988, Negative: Mouse spot test; Histidine reversion-Ames test
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EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S cerevisiae-homozygosis
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EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used in manufacturing slime-control agents and as effective germicide and preservative
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EPA TSCA Section 8(d) unpublished health/safety studies
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat
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NCITR* NCI-TR-155,1979
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NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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REFERENCES:
CODEN
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REFERENCE
85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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BJPCAL
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British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For
publisher information, see BJPCBM.
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CBINA8
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Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick,
Ireland) V.1- 1969-
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CMSHAF
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Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-
1972-
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EMMUEG
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Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.10- 1987-
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EVSRBT
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Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1-
1972-
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FAATDF
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Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2
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FCTOD7
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Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford,
NY 10523) V.20- 1982-
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FMCHA2
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Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
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GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
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IMEMDT
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IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
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IMSUDL
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IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210) No.1- 1979-
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JACTDZ
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Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New
York, NY 10128) V.1-12, 1982-1993. Discontinued.
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NCITR*
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National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205.
For publisher information, see NTPTR*.
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TECSDY
|
Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave.,
New York, NY 10016) V.3(3/4)- 1981-
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VCVGK*
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"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia".
(Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia,
1994.
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