The Registry of Toxic Effects of Chemical Substances
Phenol, 2,3,5,6 - tetrachloro - |
UPDATE: February 2004 | MW: 231.88 | MF: C6H2Cl4O |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster lung | 60 mg/L | MUREAV 241,175,1990 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal mouse | lethal dose (50 percent kill): 48 mg/kg | N/R | VCVGK* -,245,1994 |
oral gerbil | lethal dose (50 percent kill): 979 mg/kg | N/R | ARTODN 40,63,1978 |
oral mouse | lethal dose (50 percent kill): 89 mg/kg | N/R | VCVGK* -,245,1994 |
oral rat | lowest published toxic dose: 300 mg/kg |
Gastrointestinal: Other changes Liver: Change in gall bladder structure or function Liver: Other changes | VCVGK* -,248,1994 |
skin rat | lowest published lethal dose: 2 gm/kg |
Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness | BECTA6 31,680,1983 |
skin rat | lethal dose (20 percent kill): 2 mg/kg/1 hour | N/R | VCVGK* -,248,1994 |
skin rat | lethal dose (10 percent kill): 2 mg/kg/1 hour | N/R | VCVGK* -,248,1994 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral rat | lowest published toxic dose: 700 mg/kg/7 day- intermittent |
Liver: Other changes Gastrointestinal: Other changes Liver: Change in gall bladder structure or function | VCVGK* -,248,1994 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
N/R | N/R | N/R |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
N/R |
REFERENCES: | |
CODEN |
REFERENCE |
ARTODN | Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- |
BECTA6 | Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
VCVGK* | "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. |