The Registry of Toxic Effects of Chemical Substances

Phenol, 2,3,5,6 - tetrachloro -

RTECS #: SM9450000

CAS #: 935-95-5

UPDATE: February 2004 MW: 231.88 MF: C6H2Cl4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REFERENCES:

SYNONYMS:

  1. 2,3,5,6 - Tetrachlorophenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 60 mg/L MUREAV 241,175,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 48 mg/kg N/R VCVGK* -,245,1994
oral
gerbil 		lethal dose (50 percent kill): 979 mg/kg N/R ARTODN 40,63,1978
oral
mouse 		lethal dose (50 percent kill): 89 mg/kg N/R VCVGK* -,245,1994
oral
rat 		lowest published toxic dose: 300 mg/kg Gastrointestinal: Other changes

Liver: Change in gall bladder structure or function

Liver: Other changes 		VCVGK* -,248,1994
skin
rat 		lowest published lethal dose: 2 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness 		BECTA6 31,680,1983
skin
rat 		lethal dose (20 percent kill): 2 mg/kg/1 hour N/R VCVGK* -,248,1994
skin
rat 		lethal dose (10 percent kill): 2 mg/kg/1 hour N/R VCVGK* -,248,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 700 mg/kg/7 day- intermittent Liver: Other changes

Gastrointestinal: Other changes

Liver: Change in gall bladder structure or function 		VCVGK* -,248,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Mutagen

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