The Registry of Toxic Effects of Chemical Substances

Phenol, nonyl -

RTECS #: SM5600000

CAS #: 25154-52-3

UPDATE: May 2005 MW: 220.39 MF: C15H24O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Hydroxyl No. 253
  2. Monononylphenol
  3. Nonyl phenol (mixed isomers)
  1. Nonylphenol
  2. Nonylphenol mixture
  3. n - Nonylphenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg open irritation test moderate UCDS** 6/9/1959


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 19 gm/kg (21 day male/21 day prior to copulation-13 day after birth) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 154 mg/kg (21 day male/21 day prior to copulation-2 week after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 4 gm/kg (21 day male/21 day prior to copulation-13 day after birth) Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 770 mg/kg (21 day male/21 day prior to copulation-2 week after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 3,850 mg/kg (multigeneration)) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 154 mg/kg (multigeneration)) Reproductive: Specific developmental abnormalities: Endocrine system REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 2 mg/kg (multigeneration)) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Biochemical and metabolic 		FCTOD7 40,53,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
non-mammalian species 		lowest published toxic dose: 2.5 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 72,192,2003
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg Liver: Other changes TXCYAC 175,49,2002
oral
mouse 		lethal dose (50 percent kill): 1,231 mg/kg N/R NTIS** AD-A067-313
oral
rat 		lethal dose (50 percent kill): 580 mg/kg N/R NTIS** OTS0573098
skin
rabbit 		lethal dose (50 percent kill): 2,140 µL/kg N/R AIHAAP 30,470,1969
skin
rabbit 		lethal dose (50 percent kill): 2,140 mg/kg N/R VCVGK* -,223,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 600 mg/kg/10 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Related to Chronic Data: Changes in testicular weight 		TXCYAC 175,49,2002
oral
rat 		lowest published toxic dose: 1,589 mg/kg/29 day- continuous Nutritional and Gross Metabolic: Other changes NTIS** OTS0573098
oral
rat 		lowest published toxic dose: 14,000 mg/kg/56 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 3,500 mg/kg/2 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 4,200 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Liver: Changes in liver weight

Brain and Coverings: Changes in brain weight 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 168 mg/kg/12 week- intermittent Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 2,800 mg/kg/56 day- intermittent Kidney, Ureter, and Bladder: Other changes

Reproductive: Maternal effects: Ovaries, fallopian tubes 		REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 112 mg/kg/56 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 15,293,2001
oral
rat 		lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		TOLED5 143,261,2003
oral
rat 		lowest published toxic dose: 21 gm/kg/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ETOPFR 17,19,2004
oral
rat 		lowest published toxic dose: 15,750 mg/kg/6 week- intermittent Endocrine: Changes in thymus weight ETOPFR 17,19,2004
oral
rat 		lowest published toxic dose: 5,250 mg/kg/6 week- intermittent Biochemical: Metabolism (intermediary): Other ETOPFR 17,19,2004
subcutaneous
mouse 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight

Endocrine: Estrogenic 		EVHPAZ 104,1296,1996
subcutaneous
pig 		lowest published toxic dose: 560 mg/kg/14 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina 		REPTED 16,29,2002
subcutaneous
rat 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,311,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TOLED5 127,225,2002
TOXICOLOGY REVIEW
TOLED5 131,75,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83208;
Number of Industries 58;
Total Number of Facilities 3,891;
Number of Occupations 60;
Total Number of Employees Exposed 67,708
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83208;
Number of Industries 151;
Total Number of Facilities 27,721;
Number of Occupations 108;
Total Number of Employees Exposed 306,211;
Total Number of Female Employees Exposed 42,765


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of synthetic organic detergents, synthetic rubber and oil additives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9019
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in manufacture of synthetic organic detergents, synthetic rubber and oil additives

RTECS Compound Description:
   Primary Irritant

ALT CAS #: 25154-52-3
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