The Registry of Toxic Effects of Chemical Substances

Phenol, p - nitro -

RTECS #: SM2275000

CAS #: 100-02-7

UPDATE: February 2005 MW: 139.12 MF: C6H5NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 4 - Hydroxynitrobenzene
  2. 4 - Nitrofenol (Dutch)
  3. 4 - Nitrophenol
  4. NCI - C55992
  5. Niphen
  6. Paranitrofenol (Dutch)
  1. Paranitrofenolo (Italian)
  2. Paranitrophenol (French,German)
  3. RCRA waste number U170
  4. p - Nitrofenol (Czech)
  5. p - Nitrophenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct Escherichia coli 50 µmol/L MUREAV 89,95,1981
DNA damage rat liver 700 µmol/L EMMUEG 24,181,1994
DNA repair Bacillus subtilis 500 µg/disc MUREAV 170,11,1986
DNA repair other microorganisms 10 mg/plate BIZNAT 95,463,1976
gene conversion and mitotic recombination Saccharomyes cerevisiae 21 mmol/L IARCCD 10,161,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lethal dose (50 percent kill): 90 mg/kg N/R PCBPBS 8,302,1978
intramuscular
pigeon 		lowest published lethal dose: 65 mg/kg N/R JPETAB 49,187,1933
intraperitoneal
mouse 		lethal dose (50 percent kill): 75 mg/kg N/R NTIS** AD691-490
intravenous
dog 		lowest published lethal dose: 10 mg/kg N/R XPHBAO 271,131,1941
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 247 mg/kg N/R GISAAA 45(10),16,1980
oral
mouse 		lethal dose (50 percent kill): 282 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		NTIS** OTS0570918
oral
rat 		lethal dose (50 percent kill): 202 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		NTIS** 0TS0518152
oral
rabbit 		lowest published lethal dose: 600 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Behavioral: Ataxia 		NTIS** 0TS0518150
subcutaneous
frog 		lowest published lethal dose: 60 mg/kg Behavioral: Tremor

Behavioral: Muscle weakness

Behavioral: Ataxia 		RMSRA6 16,449,1896
subcutaneous
guinea pig 		lowest published lethal dose: 200 mg/kg Behavioral: Muscle weakness

Behavioral: Coma 		RMSRA6 16,449,1896
subcutaneous
rat 		lowest published lethal dose: 200 mg/kg Behavioral: Muscle weakness

Behavioral: Coma 		RMSRA6 16,449,1896
skin
guinea pig 		lethal dose (50 percent kill): >1 gm/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0570918
skin
mammal (species unspecified) 		lethal dose (50 percent kill): 920 mg/kg N/R GISAAA 45(10),16,1980
skin
rat 		lethal dose (50 percent kill): 1,024 mg/kg N/R NTIS** 0TS0516686
skin
rabbit 		lowest published lethal dose: 1,500 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness 		NTIS** 0TS0518150
unreported route
cat 		lethal dose (50 percent kill): 150 mg/kg N/R 30ZDA9 -,97,1971
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 175 mg/kg N/R GISAAA 39(11),13,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 63,700 mg/kg/13 week- continuous Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0526338
oral
rat 		lowest published toxic dose: 2,880 mg/kg/18 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTSCDR 26,299,2001
oral
rat 		lowest published toxic dose: 4,140 mg/kg/18 day- intermittent Behavioral: Convulsions or effect on seizure threshold JTSCDR 26,299,2001
oral
rat 		lowest published toxic dose: 11.2 gm/kg/28 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) JTSCDR 26,299,2001
oral
rat 		lowest published toxic dose: 28 gm/kg/28 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JTSCDR 26,299,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 47,75,1978
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,195,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50940;
Number of Industries 4;
Total Number of Facilities 204;
Number of Occupations 6;
Total Number of Employees Exposed 635
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50940;
Number of Industries 2;
Total Number of Facilities 116;
Number of Occupations 4;
Total Number of Employees Exposed 2,154;
Total Number of Female Employees Exposed 1,553


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110823/AS)
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate in production of dyes, photochemicals and pharmaceuticals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (derm);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used as intermediate in production of dyes, photochemicals and pharmaceuticals

NIOSH PROFILE (LEATHER TANNING), SRI, 2/77

NIOSH PROFILE (NITROPHENOLS), SRC, 4/81

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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