The Registry of Toxic Effects of Chemical Substances

Phenol, p - methylamino - , sulfate (salt)

RTECS #: SL8650000

CAS #: 55-55-0

UPDATE: October 2002 MW: 219.23 MF: C7H9NO•1/2H2O4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Armol
  2. Elon (developer)
  3. Genol
  4. Graphol
  5. Metatyl
  6. Methyl - p - aminophenol sulfate
  7. p - Methylaminophenolsulfate
  1. Metol
  2. Phenol, p - (methylamino) - , sulfate (2:1) (salt)
  3. Photol
  4. Pictol
  5. Planetol
  6. Rhodol
  7. Verol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		1%/48 hour CODEDG 11,256,1984


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 167 µg/plate (-enzymatic activation step) ENMUDM 9(Suppl 9),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published lethal dose: 50 mg/kg N/R KODAK* 21MAY1971
oral
mouse 		lethal dose (50 percent kill): 565 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Kidney, Ureter, and Bladder: Other changes in urine composition 		NTIS** OTS0570966
oral
rat 		lowest published lethal dose: 200 mg/kg N/R KODAK* 21MAY1971
skin
guinea pig 		lethal dose (50 percent kill): >1 gm/kg N/R KODAK* 21MAY1971
unreported route
guinea pig 		lethal dose (50 percent kill): 1,585 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 49(9),87,1984
unreported route
mouse 		lethal dose (50 percent kill): 769 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 49(9),87,1984
unreported route
rat 		lethal dose (50 percent kill): 705 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 49(9),87,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 9,350 mg/kg/11 day- continuous Endocrine: Changes in spleen weight

Blood: Changes in spleen 		NTIS** OTS0570966
oral
rat 		lowest published toxic dose: 6,600 mg/kg/94 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Changes in spleen weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0570966
unreported route
rat 		lowest published toxic dose: 4,300 mg/kg/61 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 49(9),87,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81914;
Number of Industries 85;
Total Number of Facilities 9,601;
Number of Occupations 47;
Total Number of Employees Exposed 40,485
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81914;
Number of Industries 37;
Total Number of Facilities 6,348;
Number of Occupations 34;
Total Number of Employees Exposed 43,146;
Total Number of Female Employees Exposed 24,720


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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