The Registry of Toxic Effects of Chemical Substances

Phenol, 4,4' - isopropylidenedi -

RTECS #: SL6300000

CAS #: 80-05-7

UPDATE: May 2005 MW: 228.31 MF: C15H16O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,2 - (4,4' - Dihydroxydiphenyl) propane
  2. 2,2 - Bis (4 - hydroxyphenyl) propane
  3. 2,2 - Bis (p - hydroxyphenyl) propane
  4. 2,2 - Bis - 4' - hydroxyfenylpropan (Czech)
  5. 2,2 - Di (4 - hydroxyphenyl) propane
  6. 2,2 - Di (4 - phenylol) propane
  7. 4,4' - Bisphenol A
  8. 4,4' - Dihydroxy - 2,2 - diphenylpropane
  9. 4,4' - Dihydroxydiphenyl - 2,2 - propane
  10. 4,4' - Dihydroxydiphenyldimethylmethane
  11. 4,4' - Dihydroxydiphenylpropane
  12. 4,4' - Isopropylidendiphenol
  13. 4,4' - Isopropylidendiphenol dust
  14. 4,4' - Isopropylidenebisphenol
  15. Bis (4 - hydroxyphenyl) dimethylmethane
  16. Bis (4 - hydroxyphenyl) propane
  17. Bisferol A (Czech)
  1. Bisphenol
  2. Bisphenol A
  3. Bisphenol A (OSHA)
  4. DIAN
  5. Dimethyl bis (p - hydroxyphenyl) methane
  6. Dimethylmethylene - p,p' - diphenol
  7. Diphenylolpropane
  8. NCI - C50635
  9. Phenol, 4,4' - dimethylmethylenedi -
  10. Propane, 2,2 - bis (p - hydroxyphenyl) -
  11. Ucar bisphenol A
  12. beta - Di - p - hydroxyphenylpropane
  13. p,p' - Dihydroxydiphenyldimethylmethane
  14. p,p' - Dihydroxydiphenylpropane
  15. p,p' - Isopropylidenebisphenol
  16. p,p' - Isopropylidenediphenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg/24 hour severe 85JCAE -,238,1986
skin
rabbit 		250 mg open irritation test mild UCDS** 7/14/1965
skin
rabbit 		500 mg/24 hour mild 85JCAE -,238,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 400 µmol/L MUREAV 400,169,1998
DNA adduct intraperitoneal
rat 		200 mg/kg EMMUEG 26,60,1995
DNA adduct oral
rat 		800 mg/kg/4 day- continuous EMMUEG 26,60,1995
DNA damage human Ascites tumor 25 mg/L/2 hour FCTOD7 42,1323,2004
DNA damage mouse other cell types 100 mg/L/3 hour (-enzymatic activation step) MUREAV 541,9,2003
DNA damage rat liver 200 µmol/L MUREAV 368,59,1996
DNA inhibition hamster ovary 400 µmol/L MUREAV 400,169,1998
mutation in microorganisms Salmonella typhimurium 0.1 µg/plate/24 hour (+/-enzymatic activation step) TCMUD8 22,425,2002
micronucleus test hamster lung 200 µmol/L MUREAV 390,21,1997


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 1,275 mg/kg (1-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system SWEHDO 7(Suppl 4),66,1981
intraperitoneal
rat 		lowest published toxic dose: 1,275 mg/kg (1-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) APTOD9 19,A23,1980
intraperitoneal
rat 		lowest published toxic dose: 1,875 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) 		APTOD9 19,A23,1980
intraperitoneal
rat 		lowest published toxic dose: 1,275 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system 		SWEHDO 7(Suppl 4),66,1981
intraperitoneal
rat 		lowest published toxic dose: 1,875 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Gastrointestinal system 		SWEHDO 7(Suppl 4),66,1981
oral
mouse 		lowest published toxic dose: 12,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** PB85-205102
oral
mouse 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) NTIS** PB85-205102
oral
mouse 		lowest published toxic dose: 12,500 mg/kg (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina NTIS** PB85-205102
oral
mouse 		lowest published toxic dose: 16,800 ng/kg (11-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		AMZOAF 40,429,2000
oral
mouse 		lowest published toxic dose: 14,000 ng/kg (11-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TIHEEC 14,239,1998
oral
mouse 		lowest published toxic dose: 12,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FAATDF 8,571,1987
oral
mouse 		lowest published toxic dose: 1.75 gm/kg (multigenerations) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) NTIS** #PB86103207
oral
mouse 		lowest published toxic dose: 153 gm/kg (multigenerations) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB86103207
oral
mouse 		lowest published toxic dose: 171.5 gm/kg (98 day male) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB86103207
oral
mouse 		lowest published toxic dose: 437 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** #PB86103207
oral
mouse 		lowest published toxic dose: 50 µg/kg (14-18 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral 		EVHPAZ 110(Suppl 3),415,2002
oral
mouse 		lowest published toxic dose: 14 µg/kg (11-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Behavioral 		EVHPAZ 111,175,2003
oral
mouse 		lowest published toxic dose: 560 mg/kg (8 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		LIFSAK 72,1159,2003
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB85-205110
oral
rat 		lowest published toxic dose: 15 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** PB85-205110
oral
rat 		lowest published toxic dose: 6,400 µg/kg (13-22 day pregnant/1-6 day after birth) Reproductive: Effects on newborn: Behavioral PBBHAU 64,687,1999
oral
rat 		lowest published toxic dose: 20 gm/kg (1-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus 		LIFSAK 69,2611,2001
oral
rat 		lowest published toxic dose: 0.2 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Physical 		REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 0.2 µg/kg (multigenerations) Reproductive: Effects on newborn: Behavioral REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 2 µg/kg (multigenerations) Reproductive: Effects on newborn: Physical REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 20 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 0.2 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 200 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 2 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 20 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Central nervous system REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 2,120 µg/kg (10 day prior to copulation-21 day after birth) Reproductive: Effects on newborn: Behavioral EVHPAZ 110(Suppl 3),403,2002
oral
rat 		lowest published toxic dose: 8,000 µg/kg (1-14 day pregnant/6 day after birth) Reproductive: Effects on newborn: Behavioral EVHPAZ 110(Suppl 3),403,2002
oral
rat 		lowest published toxic dose: 1,760 µg/kg (0-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects 		EVHPAZ 110(Suppl 3),409,2002
oral
rat 		lowest published toxic dose: 3.8 mg/kg (6-22 day pregnant/21 day after birth) Nutritional and Gross Metabolic: Other changes EVHPAZ 109,675,2001
oral
rat 		lowest published toxic dose: 45.6 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Delayed effects

Nutritional and Gross Metabolic: Other changes 		EVHPAZ 109,675,2001
oral
rat 		lowest published toxic dose: 132 mg/kg (10-22 day pregnant/20 day after birth) Reproductive: Effects on newborn: Behavioral ETOPFR 14,99,2003
oral
rat 		lowest published toxic dose: 800 mg/kg (10-22 day pregnant/7 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) ETOPFR 14,99,2003
subcutaneous
mouse 		lowest published toxic dose: 900 mg/kg (11-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system CGANE7 39,193,1999
subcutaneous
mouse 		lowest published toxic dose: 90 mg/kg (10-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 16,107,2002
subcutaneous
mouse 		lowest published toxic dose: 14 µg/kg (11-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical 		REPTED 16,117,2002
subcutaneous
mouse 		lowest published toxic dose: 140 µg/kg (11-17 day pregnant) Reproductive: Effects on newborn: Physical REPTED 16,117,2002
subcutaneous
rat 		lowest published toxic dose: 400 µg/kg (8-23 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system BIREBV 65,1271,2001
unreported route
rat 		lowest published toxic dose: 350 mg/kg (9-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVGK* -,234,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 86,520 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease 		NTIS** PB82-184060
oral
rat 		lowest published toxic dose: 43,260 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Reproductive: Tumorigenic effects: Testicular tumors 		NTIS** PB82-184060
oral
rat 		lowest published toxic dose: 36,050 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia 		NTIS** PB82-184060


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 20 mg/m3/1 hour Behavioral: Headache

Gastrointestinal: Nausea or vomiting 		VCVGK* -,234,1994
inhalation
mouse 		lethal concentration : >1,700 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		TPKVAL 2,50,1961
inhalation
mouse 		lowest published toxic concentration: 500 mg/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		VCVGK* -,234,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 150 mg/kg N/R VCVGK* -,234,1994
intraperitoneal
rat 		lowest published toxic dose: 37.5 mg/kg Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Other 		EVHPAZ 108,243,2000
intraperitoneal
rat 		lowest published toxic dose: 150 mg/kg Endocrine: Estrogenic EVHPAZ 108,243,2000
intraperitoneal
rat 		lethal dose (50 percent kill): 200 mg/kg N/R FCTOD7 41,1035,2003
oral
guinea pig 		lethal dose (50 percent kill): 4 gm/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		GISAAA 33(7),25,1968
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 6,500 mg/kg N/R 34ZIAG -,135,1969
oral
mouse 		lethal dose (50 percent kill): 2,400 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		GISAAA 33(7),25,1968
oral
mouse 		lethal dose (50 percent kill): 2,500 mg/kg N/R VCVGK* -,234,1994
oral
rat 		lethal dose (50 percent kill): 3,250 mg/kg N/R AIHAAP 28,301,1967
oral
rat 		lethal dose (50 percent kill): 1,200 mg/kg Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) LIFSAK 69,2611,2001
oral
rat 		lowest published toxic dose: 1,000 mg/kg Immunological Including Allergic: Decrease in cellular immune response LIFSAK 69,2611,2001
oral
rabbit 		lethal dose (50 percent kill): 2,230 mg/kg N/R VCVGK* -,234,1994
subcutaneous
mouse 		lowest published lethal dose: 2,500 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TPKVAL 2,50,1961
subcutaneous
mouse 		lowest published toxic dose: 100 µg/kg Reproductive: Maternal effects: Uterus, cervix, vagina TOXID9 72,134,2003
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg Related to Chronic Data: Changes in uterine weight

Biochemical: Metabolism (intermediary): Other proteins 		TOLED5 144,257,2003
subcutaneous
rat 		lowest published toxic dose: 5.9 mg/kg Endocrine: Estrogenic JAFCAU 18,1108,1970
subcutaneous
rabbit 		lethal dose (50 percent kill): 3,000 mg/kg N/R VCVGK* -,234,1994
skin
rabbit 		lethal dose (50 percent kill): 3 mL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 200 mg/m3/2 hour/41 day- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 2,50,1961
inhalation
mouse 		lowest published toxic concentration: 200 mg/m3/2 hour/31 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,234,1994
inhalation
rat 		lowest published toxic concentration: 150 mg/m3/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 8,248,1988
inhalation
rat 		lowest published toxic concentration: 47 mg/m3/2 hour/19 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Endocrine: Changes in spleen weight 		TPKVAL 4,43,1962
inhalation
rat 		lowest published toxic concentration: 47 mg/m3/4 hour/122 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,234,1994
intraperitoneal
rat 		lowest published toxic dose: 320 mg/kg/4 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 41,1035,2003
oral
mammal (species unspecified) 		lowest published toxic dose: 700 mg/kg/2 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JJTHEC 65,933,2002
oral
mammal (species unspecified) 		lowest published toxic dose: 3,500 mg/kg/2 week- continuous Liver: Changes in liver weight JJTHEC 65,933,2002
oral
mouse 		lowest published toxic dose: 273 gm/kg/13 week- continuous Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-215,1982
oral
mouse 		lowest published toxic dose: 12,252 mg/kg/14 day- continuous Behavioral: Food intake (animal) NTIS** #PB86103207
oral
mouse 		lowest published toxic dose: 257,250 mg/kg/21 week- intermittent Liver: Changes in liver weight NTIS** #PB86103207
oral
mouse 		lowest published toxic dose: 257,250 mg/kg/21 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB86103207
oral
mouse 		lowest published toxic dose: 257,250 mg/kg/21 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** #PB89169254
oral
mouse 		lowest published toxic dose: 18.3 gm/kg/61 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in testicular weight 		FCTOD7 41,1035,2003
oral
rat 		lowest published toxic dose: 12 mg/kg/12 day- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 2,50,1961
oral
rat 		lowest published toxic dose: 42 gm/kg/8 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARZNAD 9,9,1959
oral
rat 		lowest published toxic dose: 5,460 mg/kg/13 week- continuous Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-215,1982
oral
rat 		lowest published toxic dose: 31,500 mg/kg/9 week- intermittent Kidney, Ureter, and Bladder: Urine volume increased

Liver: Other changes

Blood: Other hemolysis with or without anemia 		GISAAA 33(7),25,1968
oral
rat 		lowest published toxic dose: 455 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Liver: Liver function tests impaired

Blood: Other changes 		GISAAA 33(7),25,1968
oral
rat 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders TOSCF2 54,154,2000
oral
rat 		lowest published toxic dose: 600 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TOSCF2 54,154,2000
oral
rat 		lowest published toxic dose: 4.2 gm/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain LIFSAK 69,2611,2001
oral
rat 		lowest published toxic dose: 7 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain LIFSAK 69,2611,2001
oral
rat 		lowest published toxic dose: 1.2 gm/kg/4 day- intermittent Behavioral: Food intake (animal) LIFSAK 69,2611,2001
oral
rat 		lowest published toxic dose: 20 gm/kg/20 day- intermittent Gastrointestinal: Other changes LIFSAK 69,2611,2001
oral
rat 		lowest published toxic dose: 2,500 mg/kg/25 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders TOSCF2 54,154,2000
oral
rat 		lowest published toxic dose: 10.25 gm/kg/22 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARTODN 75,42,2001
oral
rat 		lowest published toxic dose: 20.5 gm/kg/44 day- continuous Liver: Changes in liver weight ARTODN 75,42,2001
oral
rat 		lowest published toxic dose: 10.34 gm/kg/44 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male 		ARTODN 75,42,2001
oral
rat 		lowest published toxic dose: 41.8 gm/kg/44 day- continuous Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight 		ARTODN 75,42,2001
oral
rat 		lowest published toxic dose: 600 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		CRTOEC 14,149,2001
oral
rat 		lowest published toxic dose: 480 mg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight 		EVHPAZ 108,1147,2000
oral
rat 		lowest published toxic dose: 16,800 µg/kg/12 week- intermittent Cardiac: Changes in heart weight REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 1.4 µg/kg/1 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 1,420 µg/kg/71 day- intermittent Endocrine: Change in LH

Endocrine: Evidence of thyroid hypofunction 		REPTED 15,505,2001
oral
rat 		lowest published toxic dose: 10,000 mg/kg/10 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,234,1994
oral
rat 		lowest published toxic dose: 5,040 mg/kg/6 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 72,84,2003
oral
rat 		lowest published toxic dose: 6 µg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 188,117,2003
oral
rat 		lowest published toxic dose: 200 mg/kg/4 day- intermittent Related to Chronic Data: Changes in uterine weight REPTED 17,421,2003
oral
rat 		lowest published toxic dose: 400 mg/kg/4 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,421,2003
oral
rat 		lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		TOLED5 143,261,2003
oral
rat 		lowest published toxic dose: 1,320 mg/kg/33 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ETOPFR 14,99,2003
oral
rat 		lowest published toxic dose: 13,200 mg/kg/33 day- intermittent Endocrine: Changes in thymus weight ETOPFR 14,99,2003
oral
rabbit 		lowest published toxic dose: 31,500 mg/kg/9 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Lipids including transport 		GISAAA 33(7),25,1968
oral
rabbit 		lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes 		GISAAA 33(7),25,1968
subcutaneous
mouse 		lowest published toxic dose: 0.3 mg/kg/3 day- continuous Endocrine: Estrogenic EVHPAZ 109,55,2001
subcutaneous
mouse 		lowest published toxic dose: 300 mg/kg/3 day- continuous Endocrine: Estrogenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight 		EVHPAZ 109,55,2001
subcutaneous
mouse 		lowest published toxic dose: 25 mg/kg/5 day- intermittent Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response 		TOLED5 136,217,2003
subcutaneous
rat 		lowest published toxic dose: 0.1 mg/kg/11 day- continuous Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) JSTBBK 60,153,1997
subcutaneous
rat 		lowest published toxic dose: 273 mg/kg/15 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain CMSHAF 42,917,2001
subcutaneous
rat 		lowest published toxic dose: 1.1 mg/kg/11 day- continuous Endocrine: Estrogenic

Skin and Appendages: Other: Breast

Tumorigenic: Cells (cultured) transformed 		JSBBEZ 60,153,1997
subcutaneous
rat 		lowest published toxic dose: 2,400 mg/kg/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight 		CRTOEC 14,149,2001
subcutaneous
rat 		lowest published toxic dose: 30 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina CRTOEC 14,149,2001
subcutaneous
rat 		lowest published toxic dose: 24 mg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight 		EVHPAZ 108,1147,2000
subcutaneous
rat 		lowest published toxic dose: 150 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		JTSCDR 26,111,2001
subcutaneous
rat 		lowest published toxic dose: 1,800 mg/kg/3 day- continuous Related to Chronic Data: Changes in uterine weight FCTOD7 41,1517,2003
subcutaneous
rat 		lowest published toxic dose: 3,200 mg/kg/4 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 41,1035,2003
subcutaneous
rat 		lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on newborn: Physical 		REPTED 17,283,2003
subcutaneous
rat 		lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,283,2003
subcutaneous
rat 		lowest published toxic dose: 4,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight 		REPTED 17,283,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
FCTOD7 40,905,2002
TOXICOLOGY REVIEW
TOLED5 127,225,2002
TOXICOLOGY REVIEW
TOLED5 131,75,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
TOLED5 140-141,37,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.5 ppm (2.8 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3 (respirable dust), 2003
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3 (total dust), 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 12845;
Number of Industries 82;
Total Number of Facilities 5,427;
Number of Occupations 74;
Total Number of Employees Exposed 71,597
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0995;
Number of Industries 2;
Total Number of Facilities 6;
Number of Occupations 2;
Total Number of Employees Exposed 2,180;
Total Number of Female Employees Exposed 49
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 12845;
Number of Industries 70;
Total Number of Facilities 5,987;
Number of Occupations 78;
Total Number of Employees Exposed 92,138;
Total Number of Female Employees Exposed 15,144


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in preparation of epoxy resins and polycarbonate resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse,rat
NTP Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat NTPTR* NTP-TR-215,1982


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMZOAF American Zoologist. (American Soc. of Zoologists, Box 2739, California Lutheran College, Thousand Oaks, CA 91360) V.1- 1961-
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JSBBEZ Journal of Steroid Biochemistry and Molecular Biology. (Pergamon Press, c/o Elsevier Science, POB 945, New York, NY 10159) V.37- 1990-
JSTBBK Journal of Steroid Biochemistry. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1969-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in preparation of epoxy resins and polycarbonate resins

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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