The Registry of Toxic Effects of Chemical Substances

Phenol, 2,4 - dinitro -

RTECS #: SL2800000

CAS #: 51-28-5

UPDATE: May 2004 MW: 184.12 MF: C6H4N2O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. NSC 1532
  2. Phenol, alpha - dinitro -
  3. Aldifen
  4. Chemox PE
  5. 2,4 - Dinitrofenol (Dutch)
  6. Dinitrofenolo (Italian)
  7. alpha - Dinitrophenol
  8. 2,4 - Dinitrophenol
  9. Dinofan
  10. 2,4 - Dnp
  11. Fenoxyl carbon N
  1. 1 - Hydroxy - 2,4 - dinitrobenzene
  2. Maroxol - 50
  3. Nitro kleenup
  4. RCRA waste number P048
  5. Solfo Black B
  6. Solfo Black BB
  7. Solfo Black 2B Supra
  8. Solfo Black G
  9. Solfo Black SB
  10. Tertrosulphur Black PB
  11. Tertrosulphur PBR


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		300 mg/4 week- intermittent mild JIHTAB 30,10,1948


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
mouse 		10 gm/kg IJMRAQ 59,1442,1971
DNA damage mouse other cell types 50 mg/L/3 hour (-enzymatic activation step) MUREAV 541,9,2003
DNA damage rat liver 100 µmol/L MUREAV 368,59,1996
DNA inhibition hamster lung 7 mmol/L MUREAV 243,213,1990
mutation in microorganisms Escherichia coli 200 ppm/3 hour (-enzymatic activation step) AMNTA4 85,119,1951
other mutation test systems other fish other cell types 100 µmol/L AEEXAH (3),279,1972


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 40,800 µg/kg (10-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FCTXAV 11,31,1973
oral
rat 		lowest published toxic dose: 2,040 mg/kg (8 day prior to copulation-21 day after birth) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		PSEBAA 32,678,1935


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 300 mg/m3/30 minute N/R 85GMAT -,62,1982
intramuscular
pigeon 		lethal dose (50 percent kill): 6,500 µg/kg Nutritional and Gross Metabolic: Body temperature increase JPETAB 53,58,1935
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 28 mg/kg N/R ARZNAD 8,381,1958
intraperitoneal
mouse 		lethal dose (50 percent kill): 26 mg/kg N/R BCPCA6 18,1389,1969
intraperitoneal
rat 		lethal dose (50 percent kill): 20 mg/kg N/R JPPMAB 17,814,1965
intravenous
dog 		lowest published lethal dose: 15 mg/kg N/R JPETAB 49,187,1933
intravenous
mouse 		lethal dose (50 percent kill): 56 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TXAPA9 6,232,1964
intravenous
rat 		lethal dose (50 percent kill): 72 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TXAPA9 6,232,1964
oral
wild bird 		lethal dose (50 percent kill): 13 mg/kg N/R TXAPA9 21,315,1972
oral
cat 		lethal dose (50 percent kill): 75 mg/kg N/R 85GMAT -,62,1982
oral
dog 		lowest published lethal dose: 30 mg/kg N/R JPETAB 49,187,1933
oral
guinea pig 		lethal dose (50 percent kill): 81 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia

Behavioral: Tetany 		FATOAO 28,493,1965
oral
human 		lowest published lethal dose: 36 mg/kg Behavioral: Coma

Cardiac: Change in rate

Nutritional and Gross Metabolic: Body temperature increase 		JAMAAP 101,1333,1933
oral
mouse 		lethal dose (50 percent kill): 45 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia

Behavioral: Tetany 		FATOAO 28,493,1965
oral
mouse 		lethal dose (50 percent kill): 72 mg/kg N/R HBPTO* 2,1229,2001
oral
rat 		lowest published toxic dose: 30 mg/kg Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands 		JTSCDR 26,299,2001
oral
rat 		lethal dose (50 percent kill): 30 mg/kg N/R HBPTO* 2,1229,2001
oral
rabbit 		lethal dose (50 percent kill): 30 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia

Behavioral: Tetany 		FATOAO 28,493,1965
subcutaneous
dog 		lowest published lethal dose: 20 mg/kg N/R JPETAB 49,187,1933
subcutaneous
guinea pig 		lowest published lethal dose: 25 mg/kg Nutritional and Gross Metabolic: Body temperature increase AEPPAE 192,331,1939
subcutaneous
mouse 		lethal dose (50 percent kill): 58 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TXAPA9 6,232,1964
subcutaneous
rat 		lethal dose (50 percent kill): 25 mg/kg N/R JPETAB 49,187,1933
subcutaneous
rabbit 		lowest published lethal dose: 20 mg/kg N/R JPETAB 49,187,1933
skin
guinea pig 		lowest published lethal dose: 700 mg/kg N/R JIHTAB 30,10,1948
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 40 mg/kg N/R 30ZDA9 -,97,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
chicken 		lowest published toxic dose: 10,230 mg/kg/28 day- continuous Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0545267
oral
rat 		lowest published toxic dose: 6,510 µg/kg/30 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 31(6),3,1966
oral
rat 		lowest published toxic dose: 540 mg/kg/18 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JTSCDR 26,299,2001
oral
rat 		lowest published toxic dose: 140 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 26,299,2001
oral
rat 		lowest published toxic dose: 200 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 26,299,2001
oral
rat 		lowest published toxic dose: 180 mg/kg/18 day- intermittent Related to Chronic Data: Changes in testicular weight JTSCDR 26,299,2001
oral
rat 		lowest published toxic dose: 360 mg/kg/18 day- intermittent Brain and Coverings: Other degenerative changes JTSCDR 26,299,2001
oral
rat 		lowest published toxic dose: 360 mg/kg/18 day- intermittent Blood: Changes in erythrocyte (RBC) count JTSCDR 26,299,2001
oral
rat 		lowest published toxic dose: 2,240 mg/kg/28 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Behavioral: Rigidity (includes catalepsy)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JTSCDR 26,299,2001
oral
rabbit 		lowest published toxic dose: 126 µg/kg/30 week- intermittent Blood: Other changes GISAAA 31(6),3,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CRTXB2 1(1),93,1971


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,175,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 27110;
Number of Industries 1;
Total Number of Facilities 19;
Number of Occupations 1;
Total Number of Employees Exposed 38
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 27110;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 3;
Total Number of Employees Exposed 130;
Total Number of Female Employees Exposed 14


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264339)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for making dyes, photochemicals, pest control agents, wood preservative
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEEXAH Acta Embryologiae Experimentalis. (Industria Grafica Nazionale, Palermo, Italy) V.1-3, 1969-79.
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as intermediate for making dyes, photochemicals, pest control agents, wood preservative

NIOSH PROFILE (NITROPHENOLS), SRC, 4/81

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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