The Registry of Toxic Effects of Chemical Substances

Phenol, 2,4 - dichloro -

RTECS #: SK8575000

CAS #: 120-83-2

UPDATE: November 2004 MW: 163.00 MF: C6H4Cl2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2,4 - DCP
  2. 2,4 - Dichlorohydroxybenzene
  3. 2,4 - Dichlorophenol
  1. NCI - C55345
  2. RCRA waste number U081


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 µL/24 hour severe NTIS** OTS0534822


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1,400 µmol/L MUREAV 400,169,1998
cytogenetic analysis intraperitoneal
mouse 		180 mg/kg MUREAV 494,1,2001
DNA damage rat liver 200 µmol/L EMMUEG 24,181,1994
DNA inhibition hamster ovary 1,200 µmol/L MUREAV 400,169,1998
mutation in microorganisms Salmonella typhimurium 333 µg/plate (-enzymatic activation step) NTPTR* NTP-TR-353,1989
mutation in mammalian somatic cells mouse lymphocyte 30 mg/L NTPTR* NTP-TR-353,1989
morphological transform mouse fibroblast 20 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster ovary 3,100 µg/L NTPTR* NTP-TR-353,1989
sex chromosome loss and nondisjunction hamster lung 500 µmol/L MUREAV 182,135,1987
sperm morphology intraperitoneal
mouse 		180 mg/kg MUREAV 494,1,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 20 mg/kg (1-20 day pregnant) Reproductive: Other developmental abnormalities GISAAA 41(11),102,1976
oral
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 4,167,1984
oral
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 13,635,1989
oral
rat 		lowest published toxic dose: 22 mg/kg (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities 		VCVGK* -,247,1994
oral
rat 		lowest published toxic dose: 1,650 mg/kg (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system VCVGK* -,247,1994
oral
rat 		lowest published toxic dose: 22 mg/kg (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus 		GISAAA 40,102,1975
oral
rat 		lowest published toxic dose: 3 mg/kg (multigenerations) Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Other postnatal measures or effects 		JTEHD6 14,723,1984
oral
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus 		FAATDF 13,635,1989
subcutaneous
mouse 		lowest published toxic dose: 666 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 16 gm/kg/39 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 153 mg/kg N/R JMCMAR 18,868,1975
intraperitoneal
rat 		lethal dose (50 percent kill): 430 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase 		BJPCAL 13,20,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 430 mg/kg N/R VCVGK* -,245,1994
oral
guinea pig 		lowest published lethal dose: 2 gm/kg N/R ABANAE 7,321,1959/1960
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 464 mg/kg N/R GISAAA 45(10),16,1980
oral
mouse 		lethal dose (50 percent kill): 1,276 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		FAATDF 5,478,1985
oral
mouse 		lethal dose (50 percent kill): 1,276 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		TOLED5 29,39,1985
oral
mouse 		lethal dose (50 percent kill): 580 mg/kg N/R BFUUA* 31,1,1989
oral
rat 		lethal dose (50 percent kill): 47 mg/kg Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		NTIS** OTS0534822
oral
rat 		lethal dose (50 percent kill): 380 mg/kg N/R VCVGK* -,245,1994
subcutaneous
rat 		lethal dose (50 percent kill): 580 mg/kg N/R BFUUA* 31,1,1989
skin
mammal (species unspecified) 		lethal dose (50 percent kill): 790 mg/kg N/R GISAAA 45(10),16,1980
skin
rabbit 		lowest published lethal dose: 3,160 mg/kg Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Pulmonary emboli

Liver: Other changes 		NTIS** OTS0534822


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 mg/m3/4 hour/152 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Liver function tests impaired 		VCVGK* -,247,1994
intramuscular
mouse 		lowest published toxic dose: 40,320 mg/kg/24 week- continuous Liver: Other changes

Liver: Changes in liver weight 		TOIZAG 19,356,1972
intramuscular
rat 		lowest published toxic dose: 7,500 mg/kg/10 day- intermittent Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FAATDF 13,635,1989
intramuscular
rat 		lowest published toxic dose: 2,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 13,635,1989
intraperitoneal
guinea pig 		lowest published toxic dose: 480 mg/kg/2 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		INHEAO 34,415,1996
oral
guinea pig 		lowest published toxic dose: 106.5 mg/kg/213 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVGK* -,247,1994
oral
mouse 		lowest published toxic dose: 31,770 mg/kg/90 day- continuous Behavioral: Fluid intake

Blood: Changes in cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		FAATDF 5,478,1985
oral
mouse 		lowest published toxic dose: 437 gm/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-353,1989
oral
mouse 		lowest published toxic dose: 67,200 mg/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-353,1989
oral
mouse 		lowest published toxic dose: 591,220 mg/kg/103 week- continuous Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Active as anti-cancer agent 		NTIS** PB90-106170/AS
oral
rat 		lowest published toxic dose: 91 gm/kg/13 week- continuous Blood: Changes in bone marrow not included in above NTPTR* NTP-TR-353,1989
oral
rat 		lowest published toxic dose: 7,500 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BFUUA* 31,1,1989
oral
rat 		lowest published toxic dose: 151,410 mg/kg/103 week- continuous Blood: Leukemia

Tumorigenic: Active as anti-cancer agent 		NTIS** PB90-106170/AS


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 41,319,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal No Evidence IMEMDT 71,769,1999
TOXICOLOGY REVIEW
STEVA8 2,305,1974
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4154;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 1;
Total Number of Employees Exposed 63;
Total Number of Female Employees Exposed 23


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110757/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of pesticides and pharmaceuticals
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9261
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ.
BFUUA* Beratergremium fuer umweltrelevante Altstoffe (BUA. Gesellschaft Deutscher Chemiker. Weinheim ; New York : VCH) 1992-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in synthesis of pesticides and pharmaceuticals

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

 Click Here for Additional Information about RTECS