The Registry of Toxic Effects of Chemical Substances

Phenol, p - chloro -

RTECS #: SK2800000

CAS #: 106-48-9

UPDATE: February 2004 MW: 128.56 MF: C6H5ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Applied 3 - 78
  2. p - Chlorfenol (Czech)
  3. p - Chlorophenic acid
  4. p - Chlorophenol
  1. 4 - Chlorophenol
  2. 4 - Hydroxychlorobenzene
  3. Phenol, 4 - chloro - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg/24 hour severe 85JCAE -,523,1986
skin
rabbit 		2 mg/24 hour severe 85JCAE -,523,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
rat 		81 mg/kg ZKMAAX 25,339,1985
mutation in microorganisms Salmonella typhimurium 200 µg/plate (+enzymatic activation step) PCBPBS 10,174,1979
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) TECSDY 14,143,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 760 µg/m3/24 hour (17 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		GISAAA 57(7-8),9,1992
oral
rat 		lowest published toxic dose: 3,500 mg/kg (70 day prior to copulation) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVGK* -,244,1994
oral
rat 		lowest published toxic dose: 550 mg/kg (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVGK* -,244,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 10 gm/m3/8 hour Behavioral: Excitement

Behavioral: Irritability

Nutritional and Gross Metabolic: Other changes 		GISAAA 29(10),37,1964
inhalation
mouse 		lowest published lethal concentration: 3,200 mg/m3/2 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		GISAAA 57(7-8),9,1992
inhalation
rat 		lethal concentration (50 percent kill): 11 mg/m3 N/R GISAAA 29(10),37,1964
intraperitoneal
mouse 		lethal dose (50 percent kill): 332 mg/kg N/R JMCMAR 18,868,1975
intraperitoneal
rat 		lethal dose (50 percent kill): 281 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase 		BJPCAL 13,20,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 281 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 500 mg/kg N/R GISAAA 45(10),16,1980
oral
mouse 		lethal dose (50 percent kill): 367 mg/kg Behavioral: Excitement

Behavioral: Coma 		ZKMAAX 25,339,1985
oral
mouse 		lethal dose (50 percent kill): 1,373 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		TOLED5 29,39,1985
oral
mouse 		lethal dose (50 percent kill): 605 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
oral
rat 		lethal dose (50 percent kill): 670 mg/kg N/R FEPRA7 2,76,1943
oral
rat 		lethal dose (50 percent kill): 261 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
subcutaneous
rat 		lethal dose (50 percent kill): 1,030 mg/kg N/R FEPRA7 2,76,1943
subcutaneous
rat 		lethal dose (50 percent kill): 1,030 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
skin
mammal (species unspecified) 		lethal dose (50 percent kill): 1 gm/kg N/R GISAAA 45(10),16,1980
skin
rat 		lethal dose (50 percent kill): 1,500 mg/kg Behavioral: Muscle contraction or spasticity

Skin: After topical application: Corrosive 		GISAAA 29(10),37,1964
skin
rat 		lethal dose (50 percent kill): 1,000 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
unreported route
mouse 		lethal dose (50 percent kill): 605 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		GISAAA 54(1),68,1989
unreported route
rat 		lethal dose (50 percent kill): 625 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		GISAAA 54(1),68,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 24 µg/m3/24 hour/17 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 57(7-8),9,1992
inhalation
rat 		lowest published toxic concentration: 2 mg/m3/6 hour/17 week- intermittent Nutritional and Gross Metabolic: Other changes GISAAA 29(10),37,1964
oral
mammal (species unspecified) 		lowest published toxic dose: 182 mg/kg/26 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,244,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84588;
Number of Industries 4;
Total Number of Facilities 185;
Number of Occupations 19;
Total Number of Employees Exposed 4,844
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84588;
Number of Industries 6;
Total Number of Facilities 200;
Number of Occupations 5;
Total Number of Employees Exposed 2,796;
Total Number of Female Employees Exposed 1,865


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate, a selective solvent and a denaturant
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: o-Chlorophenol, 2014


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1962-

Used as an intermediate, a selective solvent and a denaturant

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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